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Article: Entropy-based analysis for diffusion anisotropy mapping of healthy and myelopathic spinal cord

TitleEntropy-based analysis for diffusion anisotropy mapping of healthy and myelopathic spinal cord
Authors
KeywordsDiffusion tensor imaging (DTI)
Fractional anisotropy (FA)
Microstructure
Shannon entropy
Spinal cord
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2011, v. 54 n. 3, p. 2125-2131 How to Cite?
AbstractThe present study utilized diffusion MR imaging and fractional anisotropy (FA) mapping to delineate the microstructure of spinal cord. The concept of Shannon entropy was introduced to analyze the complex microstructure of healthy and injured spinal cords based on FA map. A total of 30 volunteers were recruited in this study with informed consent, including 13 healthy adult subjects (group A, 25. ±. 3. years), 12 healthy elderly subjects (group B, 53. ±. 7. years) and 5 cervical spondylotic myelopathy (CSM) patients (group C, 53. ±. 15. years). Diffusion MRI images of cervical spinal cord were taken using pulsed gradient spin-echo-echo-planar imaging (SE-EPI) sequence with a 3. T MR system. The region of interest was defined to cover the spinal cord in FA maps. The Shannon entropy of FA values of voxels in the cord was calculated as well as the average FA values. The significant differences were determined among three groups using one-way ANOVA and post-hoc test. As compared with adult and elderly healthy subjects, the entropy of whole spinal cord was significantly lower in CSM patients (group A: 6.07. ±. 0.18; B: 6.01. ±. 0.23; C: 5.32. ±. 0.44; p<. 0.05). Whereas there were no significant difference in FA values among groups (group A: 0.62. ±. 0.08; B: 0.64. ±. 0.09; C: 0.64. ±. 0.12). In CSM patients, there was a loss of architectural structural complexity in the cervical spinal cord tissue as noted by the lower Shannon entropy value. It indicated the potential application of entropy-based analysis for the diagnosis of the severity of chronic compressive spinal cord injuries, i.e. CSM. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135300
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
Funding AgencyGrant Number
University Grant Council of Hong Kong771608M
Funding Information:

The study is supported by the General Research Fund of the University Grant Council of Hong Kong (771608M). The authors would like to thank Dr. Kin-Cheung Mak and Dr. Henry Mak for their assistance in patient recruitment and MRI scanning.

References

 

DC FieldValueLanguage
dc.contributor.authorCui, JLen_HK
dc.contributor.authorWen, CYen_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorLi, THen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2011-07-27T01:31:46Z-
dc.date.available2011-07-27T01:31:46Z-
dc.date.issued2011en_HK
dc.identifier.citationNeuroimage, 2011, v. 54 n. 3, p. 2125-2131en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135300-
dc.description.abstractThe present study utilized diffusion MR imaging and fractional anisotropy (FA) mapping to delineate the microstructure of spinal cord. The concept of Shannon entropy was introduced to analyze the complex microstructure of healthy and injured spinal cords based on FA map. A total of 30 volunteers were recruited in this study with informed consent, including 13 healthy adult subjects (group A, 25. ±. 3. years), 12 healthy elderly subjects (group B, 53. ±. 7. years) and 5 cervical spondylotic myelopathy (CSM) patients (group C, 53. ±. 15. years). Diffusion MRI images of cervical spinal cord were taken using pulsed gradient spin-echo-echo-planar imaging (SE-EPI) sequence with a 3. T MR system. The region of interest was defined to cover the spinal cord in FA maps. The Shannon entropy of FA values of voxels in the cord was calculated as well as the average FA values. The significant differences were determined among three groups using one-way ANOVA and post-hoc test. As compared with adult and elderly healthy subjects, the entropy of whole spinal cord was significantly lower in CSM patients (group A: 6.07. ±. 0.18; B: 6.01. ±. 0.23; C: 5.32. ±. 0.44; p<. 0.05). Whereas there were no significant difference in FA values among groups (group A: 0.62. ±. 0.08; B: 0.64. ±. 0.09; C: 0.64. ±. 0.12). In CSM patients, there was a loss of architectural structural complexity in the cervical spinal cord tissue as noted by the lower Shannon entropy value. It indicated the potential application of entropy-based analysis for the diagnosis of the severity of chronic compressive spinal cord injuries, i.e. CSM. © 2010 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectDiffusion tensor imaging (DTI)en_HK
dc.subjectFractional anisotropy (FA)en_HK
dc.subjectMicrostructureen_HK
dc.subjectShannon entropyen_HK
dc.subjectSpinal corden_HK
dc.subject.meshAnisotropy-
dc.subject.meshDiffusion Tensor Imaging - methods-
dc.subject.meshImage Processing, Computer-Assisted - methods-
dc.subject.meshSpinal Cord - pathology-
dc.subject.meshSpinal Cord Diseases - pathology-
dc.titleEntropy-based analysis for diffusion anisotropy mapping of healthy and myelopathic spinal corden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=54&issue=3&spage=2125&epage=2131&date=2011&atitle=Entropy-based+analysis+for+diffusion+anisotropy+mapping+of+healthy+and+myelopathic+spinal+corden_US
dc.identifier.emailHu, Y:yhud@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityHu, Y=rp00432en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2010.10.018en_HK
dc.identifier.pmid20951216-
dc.identifier.scopuseid_2-s2.0-78650247144en_HK
dc.identifier.hkuros188829en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650247144&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue3en_HK
dc.identifier.spage2125en_HK
dc.identifier.epage2131en_HK
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000286302000036-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCui, JL=37086969000en_HK
dc.identifier.scopusauthoridWen, CY=36731630800en_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK
dc.identifier.scopusauthoridLi, TH=36731309200en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.citeulike8045227-

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