File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Interfacial pH: A critical factor for osteoporotic bone regeneration
  • Basic View
  • Metadata View
  • XML View
TitleInterfacial pH: A critical factor for osteoporotic bone regeneration
 
AuthorsShen, Y3
Liu, W2
Lin, K4
Pan, H2
Darvell, BW1
Peng, S2
Wen, C2
Deng, L3
Lu, WW2
Chang, J4
 
Issue Date2011
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuir
 
CitationLangmuir, 2011, v. 27 n. 6, p. 2701-2708 [How to Cite?]
DOI: http://dx.doi.org/10.1021/la104876w
 
AbstractOsteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells' milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material's surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO 3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the "standard" physiological value of 7.4. At these high values (pH > 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid-liquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering. © 2011 American Chemical Society.
 
ISSN0743-7463
2013 Impact Factor: 4.384
 
DOIhttp://dx.doi.org/10.1021/la104876w
 
ISI Accession Number IDWOS:000288039500085
Funding AgencyGrant Number
NSFC/RGCN_HKU 739/10
Hong Kong RGCHKU7153/06E
714908/081
Science and Technology Commission of Shanghai Municipality09JC1415500
Natural Science Foundation of China30730034
30900299
Funding Information:

This work was funded by grants from NSFC/RGC (Grant No. N_HKU 739/10), Hong Kong RGC HKU7153/06E &714908/081, Science and Technology Commission of Shanghai Municipality (Grant No. 09JC1415500), and Natural Science Foundation of China (Grant No. 30730034, 30900299). The authors are grateful for much technical support and guidance from the Electron Microscopy Unit of The University of Hong Kong.

 
ReferencesReferences in Scopus
 
GrantsRole of Strontium-calcium Silicate -A Novel Biomaterial in the Regeneration of Osteoporotic Bone - An In-vivo/vitro study
 
DC FieldValue
dc.contributor.authorShen, Y
 
dc.contributor.authorLiu, W
 
dc.contributor.authorLin, K
 
dc.contributor.authorPan, H
 
dc.contributor.authorDarvell, BW
 
dc.contributor.authorPeng, S
 
dc.contributor.authorWen, C
 
dc.contributor.authorDeng, L
 
dc.contributor.authorLu, WW
 
dc.contributor.authorChang, J
 
dc.date.accessioned2011-07-27T01:31:43Z
 
dc.date.available2011-07-27T01:31:43Z
 
dc.date.issued2011
 
dc.description.abstractOsteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells' milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material's surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO 3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the "standard" physiological value of 7.4. At these high values (pH > 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid-liquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering. © 2011 American Chemical Society.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLangmuir, 2011, v. 27 n. 6, p. 2701-2708 [How to Cite?]
DOI: http://dx.doi.org/10.1021/la104876w
 
dc.identifier.citeulike8810195
 
dc.identifier.doihttp://dx.doi.org/10.1021/la104876w
 
dc.identifier.eissn1520-5827
 
dc.identifier.epage2708
 
dc.identifier.hkuros188828
 
dc.identifier.isiWOS:000288039500085
Funding AgencyGrant Number
NSFC/RGCN_HKU 739/10
Hong Kong RGCHKU7153/06E
714908/081
Science and Technology Commission of Shanghai Municipality09JC1415500
Natural Science Foundation of China30730034
30900299
Funding Information:

This work was funded by grants from NSFC/RGC (Grant No. N_HKU 739/10), Hong Kong RGC HKU7153/06E &714908/081, Science and Technology Commission of Shanghai Municipality (Grant No. 09JC1415500), and Natural Science Foundation of China (Grant No. 30730034, 30900299). The authors are grateful for much technical support and guidance from the Electron Microscopy Unit of The University of Hong Kong.

 
dc.identifier.issn0743-7463
2013 Impact Factor: 4.384
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-79952601569
 
dc.identifier.spage2701
 
dc.identifier.urihttp://hdl.handle.net/10722/135299
 
dc.identifier.volume27
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuir
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLangmuir
 
dc.relation.projectRole of Strontium-calcium Silicate -A Novel Biomaterial in the Regeneration of Osteoporotic Bone - An In-vivo/vitro study
 
dc.relation.referencesReferences in Scopus
 
dc.titleInterfacial pH: A critical factor for osteoporotic bone regeneration
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Shen, Y</contributor.author>
<contributor.author>Liu, W</contributor.author>
<contributor.author>Lin, K</contributor.author>
<contributor.author>Pan, H</contributor.author>
<contributor.author>Darvell, BW</contributor.author>
<contributor.author>Peng, S</contributor.author>
<contributor.author>Wen, C</contributor.author>
<contributor.author>Deng, L</contributor.author>
<contributor.author>Lu, WW</contributor.author>
<contributor.author>Chang, J</contributor.author>
<date.accessioned>2011-07-27T01:31:43Z</date.accessioned>
<date.available>2011-07-27T01:31:43Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Langmuir, 2011, v. 27 n. 6, p. 2701-2708</identifier.citation>
<identifier.issn>0743-7463</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/135299</identifier.uri>
<description.abstract>Osteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells&apos; milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material&apos;s surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO 3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the &quot;standard&quot; physiological value of 7.4. At these high values (pH &gt; 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid-liquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering. &#169; 2011 American Chemical Society.</description.abstract>
<language>eng</language>
<publisher>American Chemical Society. The Journal&apos;s web site is located at http://pubs.acs.org/langmuir</publisher>
<relation.ispartof>Langmuir</relation.ispartof>
<title>Interfacial pH: A critical factor for osteoporotic bone regeneration</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0743-7463&amp;volume=27&amp;issue=6&amp;spage=2701&#8211;2708&amp;epage=&amp;date=2011&amp;atitle=Interfacial+pH:+a+critical+factor+for+osteoporotic+bone+regeneration</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1021/la104876w</identifier.doi>
<identifier.scopus>eid_2-s2.0-79952601569</identifier.scopus>
<identifier.hkuros>188828</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-79952601569&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>27</identifier.volume>
<identifier.issue>6</identifier.issue>
<identifier.spage>2701</identifier.spage>
<identifier.epage>2708</identifier.epage>
<identifier.eissn>1520-5827</identifier.eissn>
<identifier.isi>WOS:000288039500085</identifier.isi>
<publisher.place>United States</publisher.place>
<relation.project>Role of Strontium-calcium Silicate -A Novel Biomaterial in the Regeneration of Osteoporotic Bone - An In-vivo/vitro study</relation.project>
<identifier.citeulike>8810195</identifier.citeulike>
</item>
Author Affiliations
  1. University of Kuwait
  2. The University of Hong Kong
  3. Shanghai Jiaotong University
  4. Shanghai Institute of Ceramics Chinese Academy of Sciences