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Article: Interfacial pH: A critical factor for osteoporotic bone regeneration

TitleInterfacial pH: A critical factor for osteoporotic bone regeneration
Authors
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuir
Citation
Langmuir, 2011, v. 27 n. 6, p. 2701-2708 How to Cite?
Abstract
Osteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells' milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material's surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO 3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the "standard" physiological value of 7.4. At these high values (pH > 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid-liquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering. © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/135299
ISSN
2013 Impact Factor: 4.384
ISI Accession Number ID
Funding AgencyGrant Number
NSFC/RGCN_HKU 739/10
Hong Kong RGCHKU7153/06E
714908/081
Science and Technology Commission of Shanghai Municipality09JC1415500
Natural Science Foundation of China30730034
30900299
Funding Information:

This work was funded by grants from NSFC/RGC (Grant No. N_HKU 739/10), Hong Kong RGC HKU7153/06E &714908/081, Science and Technology Commission of Shanghai Municipality (Grant No. 09JC1415500), and Natural Science Foundation of China (Grant No. 30730034, 30900299). The authors are grateful for much technical support and guidance from the Electron Microscopy Unit of The University of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorShen, Yen_HK
dc.contributor.authorLiu, Wen_HK
dc.contributor.authorLin, Ken_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorDarvell, BWen_HK
dc.contributor.authorPeng, Sen_HK
dc.contributor.authorWen, Cen_HK
dc.contributor.authorDeng, Len_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChang, Jen_HK
dc.date.accessioned2011-07-27T01:31:43Z-
dc.date.available2011-07-27T01:31:43Z-
dc.date.issued2011en_HK
dc.identifier.citationLangmuir, 2011, v. 27 n. 6, p. 2701-2708en_HK
dc.identifier.issn0743-7463en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135299-
dc.description.abstractOsteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells' milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material's surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO 3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the "standard" physiological value of 7.4. At these high values (pH > 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid-liquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering. © 2011 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuiren_HK
dc.relation.ispartofLangmuiren_HK
dc.titleInterfacial pH: A critical factor for osteoporotic bone regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0743-7463&volume=27&issue=6&spage=2701–2708&epage=&date=2011&atitle=Interfacial+pH:+a+critical+factor+for+osteoporotic+bone+regenerationen_US
dc.identifier.emailPan, H: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/la104876wen_HK
dc.identifier.scopuseid_2-s2.0-79952601569en_HK
dc.identifier.hkuros188828en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952601569&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2701en_HK
dc.identifier.epage2708en_HK
dc.identifier.eissn1520-5827-
dc.identifier.isiWOS:000288039500085-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectRole of Strontium-calcium Silicate -A Novel Biomaterial in the Regeneration of Osteoporotic Bone - An In-vivo/vitro study-
dc.identifier.scopusauthoridShen, Y=55492340800en_HK
dc.identifier.scopusauthoridLiu, W=37061395600en_HK
dc.identifier.scopusauthoridLin, K=8893315700en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK
dc.identifier.scopusauthoridPeng, S=13402746900en_HK
dc.identifier.scopusauthoridWen, C=36731630800en_HK
dc.identifier.scopusauthoridDeng, L=7202007494en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChang, J=7601548164en_HK
dc.identifier.citeulike8810195-

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