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Article: Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells

TitleIrradiation induces bone injury by damaging bone marrow microenvironment for stem cells
Authors
KeywordsAngiography
CFU-fibroblast
Differentiation
Repopulation
Self-renewal
Issue Date2011
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 4, p. 1609-1614 How to Cite?
Abstract
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or treatment for irradiation-induced bone injury. We irradiated the distal half of the mouse left femur to study the mechanism of irradiation-induced bone injury and found that no mesenchymal stem cells (MSCs) were detected in irradiated distal femora or nonirradiated proximal femora. The MSCs in the circulation doubled at 1 week and increased fourfold after 4 wk of irradiation. The number of MSCs in the proximal femur quickly recovered, but no recovery was observed in the distal femur. The levels of free radicals were increased threefold at 1 wk and remained at this high level for 4 wk in distal femora, whereas the levels were increased at 1 wk and returned to the basal level at 4 wk in nonirradiated proximal femur. Free radicals diffuse ipsilaterally to the proximal femur through bone medullary canal. The blood vessels in the distal femora were destroyed in angiographic images, but not in the proximal femora. The osteoclasts and osteoblasts were decreased in the distal femora after irradiation, but no changes were observed in the proximal femora. The total bone volumes were not affected in proximal and distal femora. Our data indicate that irradiation produces free radicals that adversely affect the survival of MSCs in both distal and proximal femora. Irradiation injury to the vasculatures and the microenvironment affect the niches for stem cells during the recovery period.
Descriptioneid_2-s2.0-79955043850 = Erratum: Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells (Proceedings of the National Academy of Sciences of the United States of America (2011) 108 (1609-1614) DOI:10.1073/pnas. 1015350108)
Persistent Identifierhttp://hdl.handle.net/10722/135298
ISSN
2013 Impact Factor: 9.809
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCao, Xen_HK
dc.contributor.authorWu, Xen_HK
dc.contributor.authorFrassica, Den_HK
dc.contributor.authorYu, Ben_HK
dc.contributor.authorPang, Len_HK
dc.contributor.authorXian, Len_HK
dc.contributor.authorWan, Men_HK
dc.contributor.authorLei, Wen_HK
dc.contributor.authorArmour, Men_HK
dc.contributor.authorTryggestad, Een_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorWen, CYen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorFrassica, FJen_HK
dc.date.accessioned2011-07-27T01:31:41Z-
dc.date.available2011-07-27T01:31:41Z-
dc.date.issued2011en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 4, p. 1609-1614en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135298-
dc.descriptioneid_2-s2.0-79955043850 = Erratum: Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells (Proceedings of the National Academy of Sciences of the United States of America (2011) 108 (1609-1614) DOI:10.1073/pnas. 1015350108)-
dc.description.abstractRadiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or treatment for irradiation-induced bone injury. We irradiated the distal half of the mouse left femur to study the mechanism of irradiation-induced bone injury and found that no mesenchymal stem cells (MSCs) were detected in irradiated distal femora or nonirradiated proximal femora. The MSCs in the circulation doubled at 1 week and increased fourfold after 4 wk of irradiation. The number of MSCs in the proximal femur quickly recovered, but no recovery was observed in the distal femur. The levels of free radicals were increased threefold at 1 wk and remained at this high level for 4 wk in distal femora, whereas the levels were increased at 1 wk and returned to the basal level at 4 wk in nonirradiated proximal femur. Free radicals diffuse ipsilaterally to the proximal femur through bone medullary canal. The blood vessels in the distal femora were destroyed in angiographic images, but not in the proximal femora. The osteoclasts and osteoblasts were decreased in the distal femora after irradiation, but no changes were observed in the proximal femora. The total bone volumes were not affected in proximal and distal femora. Our data indicate that irradiation produces free radicals that adversely affect the survival of MSCs in both distal and proximal femora. Irradiation injury to the vasculatures and the microenvironment affect the niches for stem cells during the recovery period.en_HK
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectAngiographyen_HK
dc.subjectCFU-fibroblasten_HK
dc.subjectDifferentiationen_HK
dc.subjectRepopulationen_HK
dc.subjectSelf-renewalen_HK
dc.subject.meshBone Marrow - pathology - radiation effects-
dc.subject.meshBone Marrow Cells - metabolism - pathology - radiation effects-
dc.subject.meshFemur - metabolism - pathology - radiation effects-
dc.subject.meshMembrane Proteins - metabolism-
dc.subject.meshMesenchymal Stem Cells - metabolism - pathology - radiation effects-
dc.titleIrradiation induces bone injury by damaging bone marrow microenvironment for stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.1015350108en_HK
dc.identifier.pmid21220327en_HK
dc.identifier.pmcidPMC3029740-
dc.identifier.scopuseid_2-s2.0-79952166223en_HK
dc.identifier.hkuros188827en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952166223&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1609en_HK
dc.identifier.epage1614en_HK
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000286594800074-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCao, X=7403370374en_HK
dc.identifier.scopusauthoridWu, X=35867626100en_HK
dc.identifier.scopusauthoridFrassica, D=6602692397en_HK
dc.identifier.scopusauthoridYu, B=37003492200en_HK
dc.identifier.scopusauthoridPang, L=13307644700en_HK
dc.identifier.scopusauthoridXian, L=37121286700en_HK
dc.identifier.scopusauthoridWan, M=7202684871en_HK
dc.identifier.scopusauthoridLei, W=28367791400en_HK
dc.identifier.scopusauthoridArmour, M=35168431200en_HK
dc.identifier.scopusauthoridTryggestad, E=16305293500en_HK
dc.identifier.scopusauthoridWong, J=7404436913en_HK
dc.identifier.scopusauthoridWen, CY=36731630800en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridFrassica, FJ=7006609242en_HK

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