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- Publisher Website: 10.1002/jor.20948
- Scopus: eid_2-s2.0-73249121848
- PMID: 19603517
- WOS: WOS:000273074000012
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Article: Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing
Title | Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing | ||||
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Authors | |||||
Keywords | Delayed healing Extracorporeal shockwave (ESW) Osteogenesis Osteotendinous junction Partial patellectomy | ||||
Issue Date | 2010 | ||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | ||||
Citation | Journal of Orthopaedic Research, 2010, v. 28 n. 1, p. 70-76 How to Cite? | ||||
Abstract | Healing at the osteotendinous junction (OTJ) is challenging in orthopedic surgery. The present study aimed to test extracorporeal shockwave (ESW) in treatment of a delayed OTJ healing. Twenty-eight rabbits were used for establishing a delayed healing (DH) model at patella-patellar-tendon (PPT) complex after partial patellectomy for 4 weeks and then were divided into DH and ESW groups. In the ESW group, a single ESW treatment was given at postoperative week 6 to the PPT healing complex. The samples were harvested at week 8 and 12 for radiographic and histological evaluations with seven samples for each group at each time point. Micro-CT results showed that new bone volume was 1.18 +/- 0.61 mm(3) in the ESW group with no measurable new bone in the DH group at postoperative week 8. Scar tissue formed at the OTJ healing interface of the DH group, whereas ESW triggered high expression of VEGF in hypertrophic chondrocytes at week 8 and regeneration of the fibrocartilage zone at week 12 postoperatively. The accelerated osteogenesis could be explained by acceleration of endochondral ossification. In conclusion, ESW was able to induce osteogenesis at OTJ with delayed healing with enhanced endochondral ossification process and regeneration of fibrocartilage zone. These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/135297 | ||||
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.886 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by the Research Grants Council of the Hong Kong Special Administrative Regions (Ref. CUHK4765/08). Histological preparations were made with the help of Miss Xiaohong Yang. |
DC Field | Value | Language |
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dc.contributor.author | Qin, L | en_US |
dc.contributor.author | Wang, L | en_US |
dc.contributor.author | Wong, MWN | en_US |
dc.contributor.author | Wen, C | en_US |
dc.contributor.author | Wang, G | en_US |
dc.contributor.author | Zhang, G | en_US |
dc.contributor.author | Chan, KM | en_US |
dc.contributor.author | Cheung, WH | en_US |
dc.contributor.author | Leung, KS | en_US |
dc.date.accessioned | 2011-07-27T01:31:40Z | - |
dc.date.available | 2011-07-27T01:31:40Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Journal of Orthopaedic Research, 2010, v. 28 n. 1, p. 70-76 | en_US |
dc.identifier.issn | 0736-0266 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/135297 | - |
dc.description.abstract | Healing at the osteotendinous junction (OTJ) is challenging in orthopedic surgery. The present study aimed to test extracorporeal shockwave (ESW) in treatment of a delayed OTJ healing. Twenty-eight rabbits were used for establishing a delayed healing (DH) model at patella-patellar-tendon (PPT) complex after partial patellectomy for 4 weeks and then were divided into DH and ESW groups. In the ESW group, a single ESW treatment was given at postoperative week 6 to the PPT healing complex. The samples were harvested at week 8 and 12 for radiographic and histological evaluations with seven samples for each group at each time point. Micro-CT results showed that new bone volume was 1.18 +/- 0.61 mm(3) in the ESW group with no measurable new bone in the DH group at postoperative week 8. Scar tissue formed at the OTJ healing interface of the DH group, whereas ESW triggered high expression of VEGF in hypertrophic chondrocytes at week 8 and regeneration of the fibrocartilage zone at week 12 postoperatively. The accelerated osteogenesis could be explained by acceleration of endochondral ossification. In conclusion, ESW was able to induce osteogenesis at OTJ with delayed healing with enhanced endochondral ossification process and regeneration of fibrocartilage zone. These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | - |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | - |
dc.relation.ispartof | Journal of Orthopaedic Research | en_US |
dc.rights | Journal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Delayed healing | - |
dc.subject | Extracorporeal shockwave (ESW) | - |
dc.subject | Osteogenesis | - |
dc.subject | Osteotendinous junction | - |
dc.subject | Partial patellectomy | - |
dc.subject.mesh | Fractures, Bone - physiopathology - therapy | - |
dc.subject.mesh | High-Energy Shock Waves - therapeutic use | - |
dc.subject.mesh | Osteogenesis | - |
dc.subject.mesh | Tendon Injuries - physiopathology - therapy | - |
dc.subject.mesh | Wound Healing | - |
dc.title | Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wen, C: paulwen@hku.hk | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jor.20948 | - |
dc.identifier.pmid | 19603517 | - |
dc.identifier.scopus | eid_2-s2.0-73249121848 | - |
dc.identifier.hkuros | 188826 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 70 | en_US |
dc.identifier.epage | 76 | en_US |
dc.identifier.isi | WOS:000273074000012 | - |
dc.identifier.issnl | 0736-0266 | - |