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Article: Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing

TitleOsteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal of Orthopaedic Research, 2010, v. 28 n. 1, p. 70-76 How to Cite?
AbstractHealing at the osteotendinous junction (OTJ) is challenging in orthopedic surgery. The present study aimed to test extracorporeal shockwave (ESW) in treatment of a delayed OTJ healing. Twenty-eight rabbits were used for establishing a delayed healing (DH) model at patella-patellar-tendon (PPT) complex after partial patellectomy for 4 weeks and then were divided into DH and ESW groups. In the ESW group, a single ESW treatment was given at postoperative week 6 to the PPT healing complex. The samples were harvested at week 8 and 12 for radiographic and histological evaluations with seven samples for each group at each time point. Micro-CT results showed that new bone volume was 1.18 +/- 0.61 mm(3) in the ESW group with no measurable new bone in the DH group at postoperative week 8. Scar tissue formed at the OTJ healing interface of the DH group, whereas ESW triggered high expression of VEGF in hypertrophic chondrocytes at week 8 and regeneration of the fibrocartilage zone at week 12 postoperatively. The accelerated osteogenesis could be explained by acceleration of endochondral ossification. In conclusion, ESW was able to induce osteogenesis at OTJ with delayed healing with enhanced endochondral ossification process and regeneration of fibrocartilage zone. These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135297
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the Hong Kong Special Administrative RegionsCUHK4765/08
Funding Information:

This study was supported by the Research Grants Council of the Hong Kong Special Administrative Regions (Ref. CUHK4765/08). Histological preparations were made with the help of Miss Xiaohong Yang.

 

DC FieldValueLanguage
dc.contributor.authorQin, Len_US
dc.contributor.authorWang, Len_US
dc.contributor.authorWong, MWNen_US
dc.contributor.authorWen, Cen_US
dc.contributor.authorWang, Gen_US
dc.contributor.authorZhang, Gen_US
dc.contributor.authorChan, KMen_US
dc.contributor.authorCheung, WHen_US
dc.contributor.authorLeung, KSen_US
dc.date.accessioned2011-07-27T01:31:40Z-
dc.date.available2011-07-27T01:31:40Z-
dc.date.issued2010en_US
dc.identifier.citationJournal of Orthopaedic Research, 2010, v. 28 n. 1, p. 70-76en_US
dc.identifier.issn0736-0266en_US
dc.identifier.urihttp://hdl.handle.net/10722/135297-
dc.description.abstractHealing at the osteotendinous junction (OTJ) is challenging in orthopedic surgery. The present study aimed to test extracorporeal shockwave (ESW) in treatment of a delayed OTJ healing. Twenty-eight rabbits were used for establishing a delayed healing (DH) model at patella-patellar-tendon (PPT) complex after partial patellectomy for 4 weeks and then were divided into DH and ESW groups. In the ESW group, a single ESW treatment was given at postoperative week 6 to the PPT healing complex. The samples were harvested at week 8 and 12 for radiographic and histological evaluations with seven samples for each group at each time point. Micro-CT results showed that new bone volume was 1.18 +/- 0.61 mm(3) in the ESW group with no measurable new bone in the DH group at postoperative week 8. Scar tissue formed at the OTJ healing interface of the DH group, whereas ESW triggered high expression of VEGF in hypertrophic chondrocytes at week 8 and regeneration of the fibrocartilage zone at week 12 postoperatively. The accelerated osteogenesis could be explained by acceleration of endochondral ossification. In conclusion, ESW was able to induce osteogenesis at OTJ with delayed healing with enhanced endochondral ossification process and regeneration of fibrocartilage zone. These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres-
dc.relation.ispartofJournal of Orthopaedic Researchen_US
dc.rightsJournal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshFractures, Bone - physiopathology - therapy-
dc.subject.meshHigh-Energy Shock Waves - therapeutic use-
dc.subject.meshOsteogenesis-
dc.subject.meshTendon Injuries - physiopathology - therapy-
dc.subject.meshWound Healing-
dc.titleOsteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healingen_US
dc.typeArticleen_US
dc.identifier.emailWen, C: paulwen@hku.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.20948-
dc.identifier.pmid19603517-
dc.identifier.scopuseid_2-s2.0-73249121848-
dc.identifier.hkuros188826en_US
dc.identifier.volume28en_US
dc.identifier.issue1en_US
dc.identifier.spage70en_US
dc.identifier.epage76en_US
dc.identifier.isiWOS:000273074000012-

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