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Article: Epidemiological investigation of an outbreak of pandemic influenza A (H1N1) 2009 in a boarding school: Serological analysis of 1570 cases
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TitleEpidemiological investigation of an outbreak of pandemic influenza A (H1N1) 2009 in a boarding school: Serological analysis of 1570 cases
 
AuthorsLi, T1
Liu, Y1
Di, B1
Wang, M1
Shen, J1
Zhang, Y1
Chen, X1
Yuan, J1
Wu, J1
Li, K1
Lu, E1
Wu, Y1
Hao, A1
Chen, X1
Wang, Y1
Liu, J1
Pickerill, S3
Zheng, B2
 
Keywords2009 pandemic H1N1
Influenza
Outbreak
Serological analysis
 
Issue Date2011
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
 
CitationJournal Of Clinical Virology, 2011, v. 50 n. 3, p. 235-239 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcv.2010.11.012
 
AbstractBackground: A large number of 2009 pandemic influenza A (H1N1) infections were localized in school populations. Objectives: To describe the epidemiology, clinical features and risk factors associated with an outbreak that occurred at a vocational boarding school in Guangzhou, P.R. China. Study design: Data were collected prospectively and retrospectively through the use of on-site doctors and a post-outbreak survey and blood collection. The survey was used to confirm symptoms, and to investigate a series of flu-related factors such as dormitory conditions, health habits, vaccine history and population contact history. Blood samples were taken for serological analysis. Pandemic H1N1 infection was initially confirmed by a real-time RT-PCR assay. Following the identification of the outbreak by the Guangzhou CDC on September 4, cases were diagnosed symptomatically and retrospectively by serological analysis using the hemagglutination inhibition assay and a neutralization assay. Results: The infection rate was 32% (505/1570) and the attack rate was 22.2% (349/1570). The asymptomatic infection rate was 9.9% (156/1570). Sharing a classroom (OR = 2.17, 95% CI: 1.62-2.91) and dormitory space (OR = 2.32, 95% CI: 1.84-2.93) was associated with higher rates of infection. Opening windows for ventilation was the only control measure that significantly protected against infection. Conclusion: Social isolation and quarantine should be used to prevent the spread of infection. Ventilation and a control of air flow between classrooms and dorms should be implemented as possible. School closures may be effective if implemented early. © 2010.
 
ISSN1386-6532
2013 Impact Factor: 3.466
2013 SCImago Journal Rankings: 1.812
 
DOIhttp://dx.doi.org/10.1016/j.jcv.2010.11.012
 
ISI Accession Number IDWOS:000287229500012
Funding AgencyGrant Number
Ministry of Science and Technology of the People's Republic of China2009ZX10004-306
2009ZX10004-213
Funding Information:

Work supported by the Ministry of Science and Technology of the People's Republic of China (grants # 2009ZX10004-306 and 2009ZX10004-213).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, T
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorDi, B
 
dc.contributor.authorWang, M
 
dc.contributor.authorShen, J
 
dc.contributor.authorZhang, Y
 
dc.contributor.authorChen, X
 
dc.contributor.authorYuan, J
 
dc.contributor.authorWu, J
 
dc.contributor.authorLi, K
 
dc.contributor.authorLu, E
 
dc.contributor.authorWu, Y
 
dc.contributor.authorHao, A
 
dc.contributor.authorChen, X
 
dc.contributor.authorWang, Y
 
dc.contributor.authorLiu, J
 
dc.contributor.authorPickerill, S
 
dc.contributor.authorZheng, B
 
dc.date.accessioned2011-07-27T01:31:15Z
 
dc.date.available2011-07-27T01:31:15Z
 
dc.date.issued2011
 
dc.description.abstractBackground: A large number of 2009 pandemic influenza A (H1N1) infections were localized in school populations. Objectives: To describe the epidemiology, clinical features and risk factors associated with an outbreak that occurred at a vocational boarding school in Guangzhou, P.R. China. Study design: Data were collected prospectively and retrospectively through the use of on-site doctors and a post-outbreak survey and blood collection. The survey was used to confirm symptoms, and to investigate a series of flu-related factors such as dormitory conditions, health habits, vaccine history and population contact history. Blood samples were taken for serological analysis. Pandemic H1N1 infection was initially confirmed by a real-time RT-PCR assay. Following the identification of the outbreak by the Guangzhou CDC on September 4, cases were diagnosed symptomatically and retrospectively by serological analysis using the hemagglutination inhibition assay and a neutralization assay. Results: The infection rate was 32% (505/1570) and the attack rate was 22.2% (349/1570). The asymptomatic infection rate was 9.9% (156/1570). Sharing a classroom (OR = 2.17, 95% CI: 1.62-2.91) and dormitory space (OR = 2.32, 95% CI: 1.84-2.93) was associated with higher rates of infection. Opening windows for ventilation was the only control measure that significantly protected against infection. Conclusion: Social isolation and quarantine should be used to prevent the spread of infection. Ventilation and a control of air flow between classrooms and dorms should be implemented as possible. School closures may be effective if implemented early. © 2010.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Clinical Virology, 2011, v. 50 n. 3, p. 235-239 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jcv.2010.11.012
 
dc.identifier.citeulike8676938
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jcv.2010.11.012
 
dc.identifier.epage239
 
dc.identifier.hkuros188641
 
dc.identifier.isiWOS:000287229500012
Funding AgencyGrant Number
Ministry of Science and Technology of the People's Republic of China2009ZX10004-306
2009ZX10004-213
Funding Information:

Work supported by the Ministry of Science and Technology of the People's Republic of China (grants # 2009ZX10004-306 and 2009ZX10004-213).

 
dc.identifier.issn1386-6532
2013 Impact Factor: 3.466
2013 SCImago Journal Rankings: 1.812
 
dc.identifier.issue3
 
dc.identifier.pmid21195022
 
dc.identifier.scopuseid_2-s2.0-79851513639
 
dc.identifier.spage235
 
dc.identifier.urihttp://hdl.handle.net/10722/135282
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofJournal of Clinical Virology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntibodies, Viral - blood
 
dc.subject.meshDisease Outbreaks
 
dc.subject.meshHemagglutination Inhibition Tests
 
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - isolation and purification
 
dc.subject.meshInfluenza, Human - epidemiology - pathology - virology
 
dc.subject2009 pandemic H1N1
 
dc.subjectInfluenza
 
dc.subjectOutbreak
 
dc.subjectSerological analysis
 
dc.titleEpidemiological investigation of an outbreak of pandemic influenza A (H1N1) 2009 in a boarding school: Serological analysis of 1570 cases
 
dc.typeArticle
 
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<contributor.author>Shen, J</contributor.author>
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<description.abstract>Background: A large number of 2009 pandemic influenza A (H1N1) infections were localized in school populations. Objectives: To describe the epidemiology, clinical features and risk factors associated with an outbreak that occurred at a vocational boarding school in Guangzhou, P.R. China. Study design: Data were collected prospectively and retrospectively through the use of on-site doctors and a post-outbreak survey and blood collection. The survey was used to confirm symptoms, and to investigate a series of flu-related factors such as dormitory conditions, health habits, vaccine history and population contact history. Blood samples were taken for serological analysis. Pandemic H1N1 infection was initially confirmed by a real-time RT-PCR assay. Following the identification of the outbreak by the Guangzhou CDC on September 4, cases were diagnosed symptomatically and retrospectively by serological analysis using the hemagglutination inhibition assay and a neutralization assay. Results: The infection rate was 32% (505/1570) and the attack rate was 22.2% (349/1570). The asymptomatic infection rate was 9.9% (156/1570). Sharing a classroom (OR = 2.17, 95% CI: 1.62-2.91) and dormitory space (OR = 2.32, 95% CI: 1.84-2.93) was associated with higher rates of infection. Opening windows for ventilation was the only control measure that significantly protected against infection. Conclusion: Social isolation and quarantine should be used to prevent the spread of infection. Ventilation and a control of air flow between classrooms and dorms should be implemented as possible. School closures may be effective if implemented early. &#169; 2010.</description.abstract>
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Author Affiliations
  1. Guangdong Center for Disease Control and Prevention
  2. The University of Hong Kong
  3. Ustar Biotechnology, Ltd.