Article: Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon
| Title | Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon |
|---|---|
| Authors | Tang, BSF Chan, JFW Chen, M Tsang, OTY Mok, MY Lai, RWM Lee, R Que, TL Tse, H Li, IWS To, KKW Cheng, VCC Chan, EYT Zheng, B Yuen, KY |
| Issue Date | 2010 |
| Publisher | American Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/ |
| Citation | Clinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138 [How to Cite?] DOI: http://dx.doi.org/10.1128/CVI.00053-10 |
| Abstract | Acquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved. |
| ISSN | 1556-6811 2011 Impact Factor: 2.546 2011 SCImago Journal Rankings: 0.248 |
| DOI | http://dx.doi.org/10.1128/CVI.00053-10 |
| PubMed Central ID | PMC2897261 |
| References | References in Scopus |
| dc.contributor.author | Tang, BSF | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Chan, JFW | ||||||
| dc.contributor.author | Chen, M | ||||||
| dc.contributor.author | Tsang, OTY | ||||||
| dc.contributor.author | Mok, MY | ||||||
| dc.contributor.author | Lai, RWM | ||||||
| dc.contributor.author | Lee, R | ||||||
| dc.contributor.author | Que, TL | ||||||
| dc.contributor.author | Tse, H | ||||||
| dc.contributor.author | Li, IWS | ||||||
| dc.contributor.author | To, KKW | ||||||
| dc.contributor.author | Cheng, VCC | ||||||
| dc.contributor.author | Chan, EYT | ||||||
| dc.contributor.author | Zheng, B | ||||||
| dc.contributor.author | Yuen, KY | ||||||
| dc.date.accessioned | 2011-07-27T01:31:01Z | ||||||
| dc.date.available | 2011-07-27T01:31:01Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | Acquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved. | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.identifier.citation | Clinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138 [How to Cite?] DOI: http://dx.doi.org/10.1128/CVI.00053-10 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1128/CVI.00053-10 | ||||||
| dc.identifier.epage | 1138 | ||||||
| dc.identifier.hkuros | 188633 | ||||||
| dc.identifier.isi | WOS:000280536700011
Funding Information: This work was partly funded by the HKSAR Research Fund-commissioned Block Grant for the Control of Infectious Diseases and by the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China. | ||||||
| dc.identifier.issn | 1556-6811 2011 Impact Factor: 2.546 2011 SCImago Journal Rankings: 0.248 | ||||||
| dc.identifier.issue | 7 | ||||||
| dc.identifier.pmcid | PMC2897261 | ||||||
| dc.identifier.pmid | 20445006 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77954358938 | ||||||
| dc.identifier.spage | 1132 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/135275 | ||||||
| dc.identifier.volume | 17 | ||||||
| dc.language | eng | ||||||
| dc.publisher | American Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/ | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Clinical and Vaccine Immunology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Clinical and Vaccine Immunology. Copyright © American Society for Microbiology. | ||||||
| dc.subject.mesh | Acquired Immunodeficiency Syndrome - complications - etiology | ||||||
| dc.subject.mesh | Autoantibodies - blood | ||||||
| dc.subject.mesh | Burkholderia Infections - etiology - immunology | ||||||
| dc.subject.mesh | Interferon-gamma - immunology | ||||||
| dc.subject.mesh | Mycoses - etiology - immunology | ||||||
| dc.title | Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon | ||||||
| dc.type | Article |
Author Affiliations
- Tuen Mun Hospital
- The University of Hong Kong
- Prince of Wales Hospital Hong Kong
- Pamela Youde Nethersole Eastern Hospital
- Queen Mary Hospital Hong Kong