File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon

TitleDisseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon
Authors
Issue Date2010
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
Citation
Clinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138 How to Cite?
AbstractAcquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135275
ISSN
2015 Impact Factor: 2.277
2015 SCImago Journal Rankings: 1.329
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
HKSAR
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China
Funding Information:

This work was partly funded by the HKSAR Research Fund-commissioned Block Grant for the Control of Infectious Diseases and by the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China.

References

 

DC FieldValueLanguage
dc.contributor.authorTang, BSFen_HK
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorChen, Men_HK
dc.contributor.authorTsang, OTYen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLai, RWMen_HK
dc.contributor.authorLee, Ren_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorLi, IWSen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2011-07-27T01:31:01Z-
dc.date.available2011-07-27T01:31:01Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138en_HK
dc.identifier.issn1556-6811en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135275-
dc.description.abstractAcquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/ en_HK
dc.relation.ispartofClinical and Vaccine Immunologyen_HK
dc.rightsClinical and Vaccine Immunology. Copyright © American Society for Microbiology.-
dc.subject.meshAcquired Immunodeficiency Syndrome - complications - etiology-
dc.subject.meshAutoantibodies - blood-
dc.subject.meshBurkholderia Infections - etiology - immunology-
dc.subject.meshInterferon-gamma - immunology-
dc.subject.meshMycoses - etiology - immunology-
dc.titleDisseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferonen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailTse, H: htse@hkucc.hku.hken_HK
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityTse, H=rp00519en_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/CVI.00053-10en_HK
dc.identifier.pmid20445006-
dc.identifier.pmcidPMC2897261-
dc.identifier.scopuseid_2-s2.0-77954358938en_HK
dc.identifier.hkuros188633en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954358938&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1132en_HK
dc.identifier.epage1138en_HK
dc.identifier.isiWOS:000280536700011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, BSF=8908243000en_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridChen, M=26028797000en_HK
dc.identifier.scopusauthoridTsang, OTY=6602450830en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridLai, RWM=7201986840en_HK
dc.identifier.scopusauthoridLee, R=7408203830en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridTse, H=7006070596en_HK
dc.identifier.scopusauthoridLi, IWS=24464179500en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats