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Article: Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon
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TitleDisseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon
 
AuthorsTang, BSF1
Chan, JFW1
Chen, M1
Tsang, OTY1
Mok, MY1
Lai, RWM3
Lee, R4
Que, TL2
Tse, H1
Li, IWS1
To, KKW1
Cheng, VCC1
Chan, EYT5
Zheng, B1
Yuen, KY1
 
Issue Date2010
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
 
CitationClinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00053-10
 
AbstractAcquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
 
ISSN1556-6811
2012 Impact Factor: 2.598
2012 SCImago Journal Rankings: 0.938
 
DOIhttp://dx.doi.org/10.1128/CVI.00053-10
 
PubMed Central IDPMC2897261
 
ISI Accession Number IDWOS:000280536700011
Funding AgencyGrant Number
HKSAR
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China
Funding Information:

This work was partly funded by the HKSAR Research Fund-commissioned Block Grant for the Control of Infectious Diseases and by the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTang, BSF
 
dc.contributor.authorChan, JFW
 
dc.contributor.authorChen, M
 
dc.contributor.authorTsang, OTY
 
dc.contributor.authorMok, MY
 
dc.contributor.authorLai, RWM
 
dc.contributor.authorLee, R
 
dc.contributor.authorQue, TL
 
dc.contributor.authorTse, H
 
dc.contributor.authorLi, IWS
 
dc.contributor.authorTo, KKW
 
dc.contributor.authorCheng, VCC
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorZheng, B
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2011-07-27T01:31:01Z
 
dc.date.available2011-07-27T01:31:01Z
 
dc.date.issued2010
 
dc.description.abstractAcquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationClinical And Vaccine Immunology, 2010, v. 17 n. 7, p. 1132-1138 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00053-10
 
dc.identifier.doihttp://dx.doi.org/10.1128/CVI.00053-10
 
dc.identifier.epage1138
 
dc.identifier.hkuros188633
 
dc.identifier.isiWOS:000280536700011
Funding AgencyGrant Number
HKSAR
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China
Funding Information:

This work was partly funded by the HKSAR Research Fund-commissioned Block Grant for the Control of Infectious Diseases and by the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, Health, Welfare, and Food Bureau, of the Hong Kong Special Administrative Region, China.

 
dc.identifier.issn1556-6811
2012 Impact Factor: 2.598
2012 SCImago Journal Rankings: 0.938
 
dc.identifier.issue7
 
dc.identifier.pmcidPMC2897261
 
dc.identifier.pmid20445006
 
dc.identifier.scopuseid_2-s2.0-77954358938
 
dc.identifier.spage1132
 
dc.identifier.urihttp://hdl.handle.net/10722/135275
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical and Vaccine Immunology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsClinical and Vaccine Immunology. Copyright © American Society for Microbiology.
 
dc.subject.meshAcquired Immunodeficiency Syndrome - complications - etiology
 
dc.subject.meshAutoantibodies - blood
 
dc.subject.meshBurkholderia Infections - etiology - immunology
 
dc.subject.meshInterferon-gamma - immunology
 
dc.subject.meshMycoses - etiology - immunology
 
dc.titleDisseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon
 
dc.typeArticle
 
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<description.abstract>Acquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkholderiosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with culture-positive extraintestinal nontyphoidal salmonellosis, 5 out of 28 (17.9%) with serological evidence of melioidosis, and 7 out of 13 (53.8%) with culture-positive nontuberculous mycobacteriosis possessed autoantibody against gamma interferon, whereas only 1 out of 100 patients with systemic lupus erythematosus did. Our study represents the first and largest case series linking this emerging immunodeficiency syndrome with these atypical infections in apparently immunocompetent hosts. Thus, we advocate that any patient with unexplained recurrent or polymicrobial infections due to these intracellular pathogens should be screened for acquired immunodeficiency due to autoantibody against gamma interferon. Copyright &#169; 2010, American Society for Microbiology. All Rights Reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Tuen Mun Hospital
  3. Prince of Wales Hospital Hong Kong
  4. Pamela Youde Nethersole Eastern Hospital
  5. Queen Mary Hospital Hong Kong