Article: Long-term evolution and transmission dynamics of swine influenza A virus

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TitleLong-term evolution and transmission dynamics of swine influenza A virus
AuthorsVijaykrishna, D1 2 4
Smith, GJD1 2 4
Pybus, OG6
Zhu, H1 4
Bhatt, S6
Poon, LLM1
Riley, S3
Bahl, J1 2 4
Ma, SK1
Cheung, CL1
Perera, RAPM1
Chen, H1 4
Shortridge, KF1 4
Webby, RJ5
Webster, RG1 5
Guan, Y1 4
Peiris, JSM1 3
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
CitationNature, 2011, v. 473 n. 7348, p. 519-522 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature10004
AbstractSwine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease 1 and occasionally give rise to human pandemics 2, including that caused by the H1N1/2009 virus 3,4. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic 4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans. © 2011 Macmillan Publishers Limited. All rights reserved.
DescriptionLetter
ISSN0028-0836
2011 Impact Factor: 36.28
2011 SCImago Journal Rankings: 7.767
DOIhttp://dx.doi.org/10.1038/nature10004
ISI Accession Number IDWOS:000290951300042
Funding AgencyGrant Number
National Institute of Allergy and Infectious Diseases (NIAID)HHSN26600700005C
University Grants Commission of the Hong Kong SAR GovernmentAoE/M-12/06
Royal Society of London
UK COSI
Agency for Science, Technology and Research
Ministry of Health, Singapore
Funding Information:

This research was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN26600700005C and the Area of Excellence Scheme of the University Grants Commission (grant AoE/M-12/06) of the Hong Kong SAR Government. We acknowledge the Food and Environmental Hygiene Department of Hong Kong for facilitating the study. We acknowledge support from The Royal Society of London (O.G.P.), UK COSI (S.B.), NIAID (G.J.D.S.), the Agency for Science, Technology and Research and the Ministry of Health, Singapore (D.V., G.J.D.S and J.B.). We thank C. Y. H. Leung for producing some of the ferret antisera used in this study.

ReferencesReferences in Scopus
GrantsControl of Pandemic and Inter-pandemic Influenza
DC Field
Value
dc.contributor.authorVijaykrishna, D
dc.contributor.authorSmith, GJD
dc.contributor.authorPybus, OG
dc.contributor.authorZhu, H
dc.contributor.authorBhatt, S
dc.contributor.authorPoon, LLM
dc.contributor.authorRiley, S
dc.contributor.authorBahl, J
dc.contributor.authorMa, SK
dc.contributor.authorCheung, CL
dc.contributor.authorPerera, RAPM
dc.contributor.authorChen, H
dc.contributor.authorShortridge, KF
dc.contributor.authorWebby, RJ
dc.contributor.authorWebster, RG
dc.contributor.authorGuan, Y
dc.contributor.authorPeiris, JSM
dc.date.accessioned2011-07-27T01:30:58Z
dc.date.available2011-07-27T01:30:58Z
dc.date.issued2011
dc.description.abstractSwine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease 1 and occasionally give rise to human pandemics 2, including that caused by the H1N1/2009 virus 3,4. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic 4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans. © 2011 Macmillan Publishers Limited. All rights reserved.
dc.description.grantControl of Pandemic and Inter-pandemic Influenza
dc.description.grantcode97655
dc.description.naturelink_to_subscribed_fulltext
dc.descriptionLetter
dc.identifier.citationNature, 2011, v. 473 n. 7348, p. 519-522 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature10004
dc.identifier.citeulike9339224
dc.identifier.doihttp://dx.doi.org/10.1038/nature10004
dc.identifier.epage522
dc.identifier.hkuros188540
dc.identifier.isiWOS:000290951300042
Funding AgencyGrant Number
National Institute of Allergy and Infectious Diseases (NIAID)HHSN26600700005C
University Grants Commission of the Hong Kong SAR GovernmentAoE/M-12/06
Royal Society of London
UK COSI
Agency for Science, Technology and Research
Ministry of Health, Singapore
Funding Information:

This research was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN26600700005C and the Area of Excellence Scheme of the University Grants Commission (grant AoE/M-12/06) of the Hong Kong SAR Government. We acknowledge the Food and Environmental Hygiene Department of Hong Kong for facilitating the study. We acknowledge support from The Royal Society of London (O.G.P.), UK COSI (S.B.), NIAID (G.J.D.S.), the Agency for Science, Technology and Research and the Ministry of Health, Singapore (D.V., G.J.D.S and J.B.). We thank C. Y. H. Leung for producing some of the ferret antisera used in this study.

dc.identifier.issn0028-0836
2011 Impact Factor: 36.28
2011 SCImago Journal Rankings: 7.767
dc.identifier.issue7348
dc.identifier.openurl
dc.identifier.pmid21614079
dc.identifier.scopuseid_2-s2.0-79957602568
dc.identifier.spage519
dc.identifier.urihttp://hdl.handle.net/10722/135273
dc.identifier.volume473
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
dc.publisher.placeUnited Kingdom
dc.relation.ispartofNature
dc.relation.referencesReferences in Scopus
dc.subject.meshEvolution, Molecular
dc.subject.meshInfluenza A Virus, H1N1 Subtype - classification - genetics - isolation and purification - physiology
dc.subject.meshOrthomyxoviridae Infections - epidemiology - transmission - veterinary - virology
dc.subject.meshSwine - blood - virology
dc.subject.meshSwine Diseases - blood - epidemiology - transmission - virology
dc.titleLong-term evolution and transmission dynamics of swine influenza A virus
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Duke-NUS Graduate Medical School Singapore
  3. The University of Hong Kong
  4. Shantou University, Medical College (SUMC)
  5. St. Jude Children Research Hospital
  6. University of Oxford