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Article: Long-term evolution and transmission dynamics of swine influenza A virus

TitleLong-term evolution and transmission dynamics of swine influenza A virus
Authors
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2011, v. 473 n. 7348, p. 519-522 How to Cite?
AbstractSwine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease 1 and occasionally give rise to human pandemics 2, including that caused by the H1N1/2009 virus 3,4. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic 4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans. © 2011 Macmillan Publishers Limited. All rights reserved.
DescriptionLetter
Persistent Identifierhttp://hdl.handle.net/10722/135273
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
Funding AgencyGrant Number
National Institute of Allergy and Infectious Diseases (NIAID)HHSN26600700005C
University Grants Commission of the Hong Kong SAR GovernmentAoE/M-12/06
Royal Society of London
UK COSI
Agency for Science, Technology and Research
Ministry of Health, Singapore
Funding Information:

This research was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN26600700005C and the Area of Excellence Scheme of the University Grants Commission (grant AoE/M-12/06) of the Hong Kong SAR Government. We acknowledge the Food and Environmental Hygiene Department of Hong Kong for facilitating the study. We acknowledge support from The Royal Society of London (O.G.P.), UK COSI (S.B.), NIAID (G.J.D.S.), the Agency for Science, Technology and Research and the Ministry of Health, Singapore (D.V., G.J.D.S and J.B.). We thank C. Y. H. Leung for producing some of the ferret antisera used in this study.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorPybus, OGen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorBhatt, Sen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorRiley, Sen_HK
dc.contributor.authorBahl, Jen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorPerera, RAPMen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorWebby, RJen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2011-07-27T01:30:58Z-
dc.date.available2011-07-27T01:30:58Z-
dc.date.issued2011en_HK
dc.identifier.citationNature, 2011, v. 473 n. 7348, p. 519-522en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135273-
dc.descriptionLetter-
dc.description.abstractSwine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease 1 and occasionally give rise to human pandemics 2, including that caused by the H1N1/2009 virus 3,4. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic 4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans. © 2011 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshEvolution, Molecular-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - classification - genetics - isolation and purification - physiology-
dc.subject.meshOrthomyxoviridae Infections - epidemiology - transmission - veterinary - virology-
dc.subject.meshSwine - blood - virology-
dc.subject.meshSwine Diseases - blood - epidemiology - transmission - virology-
dc.titleLong-term evolution and transmission dynamics of swine influenza A virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=473&issue=7348&spage=519&epage=522&date=2011&atitle=Long-term+evolution+and+transmission+dynamics+of+swine+influenza+A+virus-
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailRiley, S: steven.riley@hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityRiley, S=rp00511en_HK
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dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature10004en_HK
dc.identifier.pmid21614079-
dc.identifier.scopuseid_2-s2.0-79957602568en_HK
dc.identifier.hkuros188540en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957602568&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume473en_HK
dc.identifier.issue7348en_HK
dc.identifier.spage519en_HK
dc.identifier.epage522en_HK
dc.identifier.eissn1476-4687-
dc.identifier.isiWOS:000290951300042-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridPybus, OG=6701390795en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridBhatt, S=26658840800en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridRiley, S=7102619416en_HK
dc.identifier.scopusauthoridBahl, J=35308668200en_HK
dc.identifier.scopusauthoridMa, SK=35215973500en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridPerera, RAPM=43861730800en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridWebby, RJ=35448064800en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike9339224-

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