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Article: Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis

TitleVirulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis
Authors
KeywordsEscherichia coli
Laribacter hongkongensis
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cellandbioscience.com
Citation
Cell & Bioscience, 2011, v. 1, article no. 17 How to Cite?
AbstractBACKGROUND: Laribacter hongkongensis is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various steps in the infective process, drug resistance and mobile genetic elements. RESULTS: For acid and bile resistance, L. hongkongensis possessed a urease gene cassette, two arc gene clusters and bile salt efflux systems. For intestinal colonization, it possessed a putative adhesin of the autotransporter family homologous to those of diffusely adherent Escherichia coli (E. coli) and enterotoxigenic E. coli. To evade from host defense, it possessed superoxide dismutase and catalases. For lipopolysaccharide biosynthesis, it possessed the same set of genes that encode enzymes for synthesizing lipid A, two Kdo units and heptose units as E. coli, but different genes for its symmetrical acylation pattern, and nine genes for polysaccharide side chains biosynthesis. It contained a number of CDSs that encode putative cell surface acting (RTX toxin and hemolysins) and intracellular cytotoxins (patatin-like proteins) and enzymes for invasion (outer membrane phospholipase A). It contained a broad variety of antibiotic resistance-related genes, including genes related to beta-lactam (n = 10) and multidrug efflux (n = 54). It also contained eight prophages, 17 other phage-related CDSs and 26 CDSs for transposases. CONCLUSIONS: The L. hongkongensis genome possessed genes for acid and bile resistance, intestinal mucosa colonization, evasion of host defense and cytotoxicity and invasion. A broad variety of antibiotic resistance or multidrug resistance genes, a high number of prophages, other phage-related CDSs and CDSs for transposases, were also identified.
Persistent Identifierhttp://hdl.handle.net/10722/135266
ISSN
2015 Impact Factor: 2.883
2015 SCImago Journal Rankings: 1.593
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorWong, GKMen_HK
dc.contributor.authorTsang, AKLen_HK
dc.contributor.authorTeng, JLLen_HK
dc.contributor.authorFan, RYYen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWoo, PCYen_HK
dc.date.accessioned2011-07-27T01:30:54Z-
dc.date.available2011-07-27T01:30:54Z-
dc.date.issued2011en_HK
dc.identifier.citationCell & Bioscience, 2011, v. 1, article no. 17en_HK
dc.identifier.issn2045-3701en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135266-
dc.description.abstractBACKGROUND: Laribacter hongkongensis is associated with community-acquired gastroenteritis and traveler's diarrhea. In this study, we performed an in-depth annotation of the genes in its genome related to the various steps in the infective process, drug resistance and mobile genetic elements. RESULTS: For acid and bile resistance, L. hongkongensis possessed a urease gene cassette, two arc gene clusters and bile salt efflux systems. For intestinal colonization, it possessed a putative adhesin of the autotransporter family homologous to those of diffusely adherent Escherichia coli (E. coli) and enterotoxigenic E. coli. To evade from host defense, it possessed superoxide dismutase and catalases. For lipopolysaccharide biosynthesis, it possessed the same set of genes that encode enzymes for synthesizing lipid A, two Kdo units and heptose units as E. coli, but different genes for its symmetrical acylation pattern, and nine genes for polysaccharide side chains biosynthesis. It contained a number of CDSs that encode putative cell surface acting (RTX toxin and hemolysins) and intracellular cytotoxins (patatin-like proteins) and enzymes for invasion (outer membrane phospholipase A). It contained a broad variety of antibiotic resistance-related genes, including genes related to beta-lactam (n = 10) and multidrug efflux (n = 54). It also contained eight prophages, 17 other phage-related CDSs and 26 CDSs for transposases. CONCLUSIONS: The L. hongkongensis genome possessed genes for acid and bile resistance, intestinal mucosa colonization, evasion of host defense and cytotoxicity and invasion. A broad variety of antibiotic resistance or multidrug resistance genes, a high number of prophages, other phage-related CDSs and CDSs for transposases, were also identified.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cellandbioscience.comen_HK
dc.relation.ispartofCell & Bioscienceen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectEscherichia coli-
dc.subjectLaribacter hongkongensis-
dc.titleVirulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hken_HK
dc.identifier.emailTsang, AKL: h0365593@hkucc.hku.hken_HK
dc.identifier.emailTeng, JLL: llteng@hkucc.hku.hken_HK
dc.identifier.emailFan, RYY: rfyy@hku.hken_HK
dc.identifier.emailTse, H: herman@graduate.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityTeng, JLL=rp00277en_HK
dc.identifier.authorityTse, H=rp00519en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/2045-3701-1-17en_HK
dc.identifier.pmid21711902-
dc.identifier.pmcidPMC3125207-
dc.identifier.scopuseid_2-s2.0-80052887983en_HK
dc.identifier.hkuros187245en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052887983&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1, article no. 17en_HK
dc.identifier.isiWOS:000307054600002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridWong, GKM=9333006300en_HK
dc.identifier.scopusauthoridTsang, AKL=7006979247en_HK
dc.identifier.scopusauthoridTeng, JLL=7202560229en_HK
dc.identifier.scopusauthoridFan, RYY=15519269300en_HK
dc.identifier.scopusauthoridTse, H=7006070596en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.citeulike10715314-

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