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Article: The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
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TitleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
 
AuthorsChan, JFW1
To, KKW1 1 1 1
Tse, H1 1 1 1
Lau, CCY1
Li, IWS1
Hung, IFN1
Chan, KH1
Cheng, VCC1
Lai, TST1
Woo, PCY1 1 1 1
Chan, EYT1
Yuen, KY1 1 1 1
 
Issue Date2011
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
 
CitationClinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00363-10
 
AbstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
 
ISSN1556-6811
2012 Impact Factor: 2.598
2012 SCImago Journal Rankings: 0.938
 
DOIhttp://dx.doi.org/10.1128/CVI.00363-10
 
PubMed Central IDPMC3067346
 
ISI Accession Number IDWOS:000286653900016
Funding AgencyGrant Number
Ted Sun Foundation
University of Hong Kong
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health
Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China
Funding Information:

This work was funded partly by the Ted Sun Foundation, an HKSAR Research Fund-commissioned block grant for the Control of Infectious Diseases, the Seed Funding Programme for Basic Research from The University of Hong Kong, and the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, the Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, JFW
 
dc.contributor.authorTo, KKW
 
dc.contributor.authorTse, H
 
dc.contributor.authorLau, CCY
 
dc.contributor.authorLi, IWS
 
dc.contributor.authorHung, IFN
 
dc.contributor.authorChan, KH
 
dc.contributor.authorCheng, VCC
 
dc.contributor.authorLai, TST
 
dc.contributor.authorWoo, PCY
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2011-07-27T01:30:48Z
 
dc.date.available2011-07-27T01:30:48Z
 
dc.date.issued2011
 
dc.description.abstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationClinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00363-10
 
dc.identifier.doihttp://dx.doi.org/10.1128/CVI.00363-10
 
dc.identifier.epage310
 
dc.identifier.hkuros187201
 
dc.identifier.isiWOS:000286653900016
Funding AgencyGrant Number
Ted Sun Foundation
University of Hong Kong
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health
Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China
Funding Information:

This work was funded partly by the Ted Sun Foundation, an HKSAR Research Fund-commissioned block grant for the Control of Infectious Diseases, the Seed Funding Programme for Basic Research from The University of Hong Kong, and the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, the Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China.

 
dc.identifier.issn1556-6811
2012 Impact Factor: 2.598
2012 SCImago Journal Rankings: 0.938
 
dc.identifier.issue2
 
dc.identifier.pmcidPMC3067346
 
dc.identifier.pmid21123524
 
dc.identifier.scopuseid_2-s2.0-79551498488
 
dc.identifier.spage305
 
dc.identifier.urihttp://hdl.handle.net/10722/135259
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical and Vaccine Immunology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsClinical and Vaccine Immunology. Copyright © American Society for Microbiology.
 
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]
 
dc.subject.meshAntibodies, Viral - blood
 
dc.subject.meshCytokines - blood
 
dc.subject.meshImmunoglobulin G - blood
 
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - pathogenicity
 
dc.subject.meshSeverity of Illness Index
 
dc.titleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong