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Article: The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation

TitleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
Citation
Clinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310 How to Cite?
AbstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135259
ISSN
2014 Impact Factor: 2.470
2013 SCImago Journal Rankings: 1.241
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Ted Sun Foundation
University of Hong Kong
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health
Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China
Funding Information:

This work was funded partly by the Ted Sun Foundation, an HKSAR Research Fund-commissioned block grant for the Control of Infectious Diseases, the Seed Funding Programme for Basic Research from The University of Hong Kong, and the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, the Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorLau, CCYen_HK
dc.contributor.authorLi, IWSen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorLai, TSTen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2011-07-27T01:30:48Z-
dc.date.available2011-07-27T01:30:48Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310en_HK
dc.identifier.issn1556-6811en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135259-
dc.description.abstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/en_HK
dc.relation.ispartofClinical and Vaccine Immunologyen_HK
dc.rightsClinical and Vaccine Immunology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]-
dc.subject.meshAntibodies, Viral - blood-
dc.subject.meshCytokines - blood-
dc.subject.meshImmunoglobulin G - blood-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - pathogenicity-
dc.subject.meshSeverity of Illness Index-
dc.titleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulationen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailTse, H: htse@hkucc.hku.hken_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityTse, H=rp00519en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/CVI.00363-10en_HK
dc.identifier.pmid21123524en_HK
dc.identifier.pmcidPMC3067346-
dc.identifier.scopuseid_2-s2.0-79551498488en_HK
dc.identifier.hkuros187201en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79551498488&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue2en_HK
dc.identifier.spage305en_HK
dc.identifier.epage310en_HK
dc.identifier.isiWOS:000286653900016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridTse, H=7006070596en_HK
dc.identifier.scopusauthoridLau, CCY=8398162900en_HK
dc.identifier.scopusauthoridLi, IWS=24464179500en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridLai, TST=37665398500en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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