Article: The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation

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TitleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
AuthorsChan, JFW
To, KKW
Tse, H
Lau, CCY
Li, IWS
Hung, IFN
Chan, KH
Cheng, VCC
Lai, TST
Woo, PCY
Chan, EYT
Yuen, KY
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
CitationClinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00363-10
AbstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
ISSN1556-6811
2011 Impact Factor: 2.546
2011 SCImago Journal Rankings: 0.248
DOIhttp://dx.doi.org/10.1128/CVI.00363-10
ISI Accession Number IDWOS:000286653900016
Funding AgencyGrant Number
Ted Sun Foundation
University of Hong Kong
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health
Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China
Funding Information:

This work was funded partly by the Ted Sun Foundation, an HKSAR Research Fund-commissioned block grant for the Control of Infectious Diseases, the Seed Funding Programme for Basic Research from The University of Hong Kong, and the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, the Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China.

PubMed Central IDPMC3067346
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, JFW
dc.contributor.authorTo, KKW
dc.contributor.authorTse, H
dc.contributor.authorLau, CCY
dc.contributor.authorLi, IWS
dc.contributor.authorHung, IFN
dc.contributor.authorChan, KH
dc.contributor.authorCheng, VCC
dc.contributor.authorLai, TST
dc.contributor.authorWoo, PCY
dc.contributor.authorChan, EYT
dc.contributor.authorYuen, KY
dc.date.accessioned2011-07-27T01:30:48Z
dc.date.available2011-07-27T01:30:48Z
dc.date.issued2011
dc.description.abstractThe majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P = 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and FcγRIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of FcγRIIa was not significantly different from that of the general Han Chinese population (P = 0.216). Only the overall cytokine/chemokine profile (P = 0.029) and serum globulin level (P = 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationClinical And Vaccine Immunology, 2011, v. 18 n. 2, p. 305-310 [How to Cite?]
DOI: http://dx.doi.org/10.1128/CVI.00363-10
dc.identifier.doihttp://dx.doi.org/10.1128/CVI.00363-10
dc.identifier.epage310
dc.identifier.hkuros187201
dc.identifier.isiWOS:000286653900016
Funding AgencyGrant Number
Ted Sun Foundation
University of Hong Kong
Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health
Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China
Funding Information:

This work was funded partly by the Ted Sun Foundation, an HKSAR Research Fund-commissioned block grant for the Control of Infectious Diseases, the Seed Funding Programme for Basic Research from The University of Hong Kong, and the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Department of Health, the Health, Welfare, and Food Bureau of the Hong Kong Special Administrative Region of China.

dc.identifier.issn1556-6811
2011 Impact Factor: 2.546
2011 SCImago Journal Rankings: 0.248
dc.identifier.issue2
dc.identifier.pmcidPMC3067346
dc.identifier.pmid21123524
dc.identifier.scopuseid_2-s2.0-79551498488
dc.identifier.spage305
dc.identifier.urihttp://hdl.handle.net/10722/135259
dc.identifier.volume18
dc.languageeng
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
dc.publisher.placeUnited States
dc.relation.ispartofClinical and Vaccine Immunology
dc.relation.referencesReferences in Scopus
dc.rightsClinical and Vaccine Immunology. Copyright © American Society for Microbiology.
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]
dc.subject.meshAntibodies, Viral - blood
dc.subject.meshCytokines - blood
dc.subject.meshImmunoglobulin G - blood
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - pathogenicity
dc.subject.meshSeverity of Illness Index
dc.titleThe lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong