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Article: Correlation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study

TitleCorrelation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study
Authors
KeywordsCoronary artery
High density lipoprotein cholesterol
Intravascular Ultrasound
Remodeling index
Issue Date2012
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1569-5794
Citation
International Journal Of Cardiovascular Imaging, 2012, v. 28 n. 1, p. 33-41 How to Cite?
AbstractSerum level of high density lipoprotein (HDL)-cholesterol is associated with risk of coronary artery disease. We correlated the serum level of cholesterol with coronary artery remodeling index of patients with coronary artery disease. A total of 120 patients with de novo lesions located in native coronary artery were studied. Remodeling index was based on intravascular ultrasound (IVUS) interrogation of the lesions using the static approach, and was defined as external elastic membrane (EEM) area at lesion/average EEM area at proximal and distal reference segments. The average remodeling index was 0.9 (SD: 0.2). The remodeling index was not associated with any of the demographic and coronary risk factors. Stable angina was associated with a low remodeling index. Remodeling index correlated with white blood cell count and HDL-cholesterol, but not with total cholesterol, LDL-cholesterol and triglyceride. In the multiple linear regression analysis, HDLcholesterol and procedure indication were the only 2 significant predictors of remodeling index. An increase of 1 mg/dL of HDL-cholesterol resulted in a decrease of 0.003 (95% CI: 0.0001, 0.007; P = 0.046) in remodeling index, after adjusting for procedural indications. When stratified according to diabetic status, the negative correlation persisted in nondiabetic (P = 0.023), but not in diabetic, patients (P = 0.707). We found a negative correlation between HDL-cholesterol level and remodeling index. Diabetic status may have an influence on the observed relationship. © Springer Science+Business Media, B.V. 2010.
Persistent Identifierhttp://hdl.handle.net/10722/135245
ISSN
2015 Impact Factor: 1.88
2015 SCImago Journal Rankings: 0.858
ISI Accession Number ID
Funding AgencyGrant Number
Yong Loo Lin School of Medicine, National University of Singapore
Funding Information:

The authors would like to thank the Publication Support Unit of the National University Health System, Singapore, for its assistance in the preparation of this manuscript. Start-up Grant, Yong Loo Lin School of Medicine, National University of Singapore.

References

 

DC FieldValueLanguage
dc.contributor.authorLee, CHen_HK
dc.contributor.authorTai, BCen_HK
dc.contributor.authorLim, GHen_HK
dc.contributor.authorChan, MYen_HK
dc.contributor.authorLow, AFen_HK
dc.contributor.authorTan, KCen_HK
dc.contributor.authorChia, BLen_HK
dc.contributor.authorTan, HCen_HK
dc.date.accessioned2011-07-27T01:30:30Z-
dc.date.available2011-07-27T01:30:30Z-
dc.date.issued2012en_HK
dc.identifier.citationInternational Journal Of Cardiovascular Imaging, 2012, v. 28 n. 1, p. 33-41en_HK
dc.identifier.issn1569-5794en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135245-
dc.description.abstractSerum level of high density lipoprotein (HDL)-cholesterol is associated with risk of coronary artery disease. We correlated the serum level of cholesterol with coronary artery remodeling index of patients with coronary artery disease. A total of 120 patients with de novo lesions located in native coronary artery were studied. Remodeling index was based on intravascular ultrasound (IVUS) interrogation of the lesions using the static approach, and was defined as external elastic membrane (EEM) area at lesion/average EEM area at proximal and distal reference segments. The average remodeling index was 0.9 (SD: 0.2). The remodeling index was not associated with any of the demographic and coronary risk factors. Stable angina was associated with a low remodeling index. Remodeling index correlated with white blood cell count and HDL-cholesterol, but not with total cholesterol, LDL-cholesterol and triglyceride. In the multiple linear regression analysis, HDLcholesterol and procedure indication were the only 2 significant predictors of remodeling index. An increase of 1 mg/dL of HDL-cholesterol resulted in a decrease of 0.003 (95% CI: 0.0001, 0.007; P = 0.046) in remodeling index, after adjusting for procedural indications. When stratified according to diabetic status, the negative correlation persisted in nondiabetic (P = 0.023), but not in diabetic, patients (P = 0.707). We found a negative correlation between HDL-cholesterol level and remodeling index. Diabetic status may have an influence on the observed relationship. © Springer Science+Business Media, B.V. 2010.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1569-5794en_HK
dc.relation.ispartofInternational Journal of Cardiovascular Imagingen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectCoronary arteryen_HK
dc.subjectHigh density lipoprotein cholesterolen_HK
dc.subjectIntravascular Ultrasounden_HK
dc.subjectRemodeling indexen_HK
dc.titleCorrelation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL studyen_HK
dc.typeArticleen_HK
dc.identifier.emailTan, KC:kcbtan@hku.hken_HK
dc.identifier.authorityTan, KC=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10554-010-9777-yen_HK
dc.identifier.pmid21197580-
dc.identifier.scopuseid_2-s2.0-84861226573en_HK
dc.identifier.hkuros188208en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861226573&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage33en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000300309800004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, CH=27867783500en_HK
dc.identifier.scopusauthoridTai, BC=7004532031en_HK
dc.identifier.scopusauthoridLim, GH=22035742600en_HK
dc.identifier.scopusauthoridChan, MY=23388249600en_HK
dc.identifier.scopusauthoridLow, AF=7102950176en_HK
dc.identifier.scopusauthoridTan, KC=8082703100en_HK
dc.identifier.scopusauthoridChia, BL=36136678600en_HK
dc.identifier.scopusauthoridTan, HC=7403011676en_HK
dc.identifier.citeulike8605273-

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