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Article: Hypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications

TitleHypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications
Authors
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
Citation
Journal Of Human Hypertension, 2012, v. 26 n. 10, p. 563-569 How to Cite?
AbstractHypertension is one of the most important risk factors associated with atrial fibrillation (AF) and increased the risk of cardiovascular events in patients with AF. However, the pathophysiological link between hypertension and AF is unclear. Nevertheless, this can be explained by the hemodynamic changes of the left atrium secondary to long standing hypertension, resulting in elevated left atrium pressure and subsequently left atrial enlargement. Moreover, the activation of renin-angiotensin-aldosterone system (RAAS) activation in patients with hypertension induces left atrial fibrosis and conduction block in the left atrium, resulting in the development of AF. Accordingly, recent studies have shown that effective blockage of RAAS by angiotensin converting enzyme inhibitors or angiotensin receptor antagonist may be effective in both primary and secondary prevention of AF in patients with hypertension, although with controversies. In addition, optimal antithrombotic therapy, blood pressure control as well as rate control for AF are key to the management of patients with AF.Journal of Human Hypertension advance online publication, 1 December 2011; doi:10.1038/jhh.2011.105.
Persistent Identifierhttp://hdl.handle.net/10722/135236
ISSN
2015 Impact Factor: 2.833
2015 SCImago Journal Rankings: 1.167
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, YFen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-07-27T01:30:24Z-
dc.date.available2011-07-27T01:30:24Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Human Hypertension, 2012, v. 26 n. 10, p. 563-569en_HK
dc.identifier.issn0950-9240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135236-
dc.description.abstractHypertension is one of the most important risk factors associated with atrial fibrillation (AF) and increased the risk of cardiovascular events in patients with AF. However, the pathophysiological link between hypertension and AF is unclear. Nevertheless, this can be explained by the hemodynamic changes of the left atrium secondary to long standing hypertension, resulting in elevated left atrium pressure and subsequently left atrial enlargement. Moreover, the activation of renin-angiotensin-aldosterone system (RAAS) activation in patients with hypertension induces left atrial fibrosis and conduction block in the left atrium, resulting in the development of AF. Accordingly, recent studies have shown that effective blockage of RAAS by angiotensin converting enzyme inhibitors or angiotensin receptor antagonist may be effective in both primary and secondary prevention of AF in patients with hypertension, although with controversies. In addition, optimal antithrombotic therapy, blood pressure control as well as rate control for AF are key to the management of patients with AF.Journal of Human Hypertension advance online publication, 1 December 2011; doi:10.1038/jhh.2011.105.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhhen_HK
dc.relation.ispartofJournal of Human Hypertensionen_HK
dc.titleHypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implicationsen_HK
dc.typeArticleen_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/jhh.2011.105en_HK
dc.identifier.pmid205359-
dc.identifier.scopuseid_2-s2.0-84866393077en_HK
dc.identifier.hkuros187315en_US
dc.identifier.isiWOS:000308688700001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, YF=54408995100en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike10092228-

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