Article: Low molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trial

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TitleLow molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trial
AuthorsSiu, CW1
Jim, MH1
Lau, CP1
Tse, HF1
KeywordsHeparin
Stroke
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14628848.asp
CitationAcute Cardiac Care, 2011, v. 13 n. 3, p. 196-198 [How to Cite?]
DOI: http://dx.doi.org/10.3109/17482941.2011.567283
AbstractWhile long-term anticoagulation prevents ischemic stroke in high-risk patients with atrial fibrillation (AF), the optimal initial anti-thrombotic regime in acute AF is less well defined. We randomized 96 patients with new onset acute AF in an emergency admission ward to receive (1) once-daily preparation of low molecular weight heparin (LMWH), tinzaparin or (2) conventional intravenous unfractionated heparin (target APTT 5070 s). 5 patients in unfractionated heparin group compared with no patients in LMWH group (0%, P = 0.04) developed ischemic stroke/transient ischemic attack during the first 48 h. An initial subcutaneous LMWH was safe and effective in ischemic stroke prevention in patients with acute AF. © 2011 Informa UK, Ltd.
ISSN1748-2941
2011 SCImago Journal Rankings: 0.079
DOIhttp://dx.doi.org/10.3109/17482941.2011.567283
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSiu, CW
dc.contributor.authorJim, MH
dc.contributor.authorLau, CP
dc.contributor.authorTse, HF
dc.date.accessioned2011-07-27T01:30:22Z
dc.date.available2011-07-27T01:30:22Z
dc.date.issued2011
dc.description.abstractWhile long-term anticoagulation prevents ischemic stroke in high-risk patients with atrial fibrillation (AF), the optimal initial anti-thrombotic regime in acute AF is less well defined. We randomized 96 patients with new onset acute AF in an emergency admission ward to receive (1) once-daily preparation of low molecular weight heparin (LMWH), tinzaparin or (2) conventional intravenous unfractionated heparin (target APTT 5070 s). 5 patients in unfractionated heparin group compared with no patients in LMWH group (0%, P = 0.04) developed ischemic stroke/transient ischemic attack during the first 48 h. An initial subcutaneous LMWH was safe and effective in ischemic stroke prevention in patients with acute AF. © 2011 Informa UK, Ltd.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationAcute Cardiac Care, 2011, v. 13 n. 3, p. 196-198 [How to Cite?]
DOI: http://dx.doi.org/10.3109/17482941.2011.567283
dc.identifier.doihttp://dx.doi.org/10.3109/17482941.2011.567283
dc.identifier.epage198
dc.identifier.hkuros187310
dc.identifier.hkuros201287
dc.identifier.hkuros208713
dc.identifier.issn1748-2941
2011 SCImago Journal Rankings: 0.079
dc.identifier.issue3
dc.identifier.pmid21517667
dc.identifier.scopuseid_2-s2.0-80052453860
dc.identifier.spage196
dc.identifier.urihttp://hdl.handle.net/10722/135232
dc.identifier.volume13
dc.languageeng
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14628848.asp
dc.publisher.placeUnited Kingdom
dc.relation.ispartofAcute Cardiac Care
dc.relation.referencesReferences in Scopus
dc.rightsAcute Cardiac Care. Copyright © Informa Healthcare.
dc.subject.meshAtrial Fibrillation - drug therapy - pathology
dc.subject.meshFibrinolytic Agents - administration and dosage - therapeutic use
dc.subject.meshHeparin - administration and dosage - therapeutic use
dc.subject.meshHeparin, Low-Molecular-Weight - administration and dosage - therapeutic use
dc.subject.meshInfusions, Intravenous
dc.subjectHeparin
dc.subjectStroke
dc.titleLow molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trial
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong