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Article: Low molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trial

TitleLow molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trial
Authors
KeywordsHeparin
Stroke
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14628848.asp
Citation
Acute Cardiac Care, 2011, v. 13 n. 3, p. 196-198 How to Cite?
AbstractWhile long-term anticoagulation prevents ischemic stroke in high-risk patients with atrial fibrillation (AF), the optimal initial anti-thrombotic regime in acute AF is less well defined. We randomized 96 patients with new onset acute AF in an emergency admission ward to receive (1) once-daily preparation of low molecular weight heparin (LMWH), tinzaparin or (2) conventional intravenous unfractionated heparin (target APTT 5070 s). 5 patients in unfractionated heparin group compared with no patients in LMWH group (0%, P = 0.04) developed ischemic stroke/transient ischemic attack during the first 48 h. An initial subcutaneous LMWH was safe and effective in ischemic stroke prevention in patients with acute AF. © 2011 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/135232
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-07-27T01:30:22Z-
dc.date.available2011-07-27T01:30:22Z-
dc.date.issued2011en_HK
dc.identifier.citationAcute Cardiac Care, 2011, v. 13 n. 3, p. 196-198en_HK
dc.identifier.issn1748-2941en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135232-
dc.description.abstractWhile long-term anticoagulation prevents ischemic stroke in high-risk patients with atrial fibrillation (AF), the optimal initial anti-thrombotic regime in acute AF is less well defined. We randomized 96 patients with new onset acute AF in an emergency admission ward to receive (1) once-daily preparation of low molecular weight heparin (LMWH), tinzaparin or (2) conventional intravenous unfractionated heparin (target APTT 5070 s). 5 patients in unfractionated heparin group compared with no patients in LMWH group (0%, P = 0.04) developed ischemic stroke/transient ischemic attack during the first 48 h. An initial subcutaneous LMWH was safe and effective in ischemic stroke prevention in patients with acute AF. © 2011 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14628848.aspen_HK
dc.relation.ispartofAcute Cardiac Careen_HK
dc.rightsAcute Cardiac Care. Copyright © Informa Healthcare.-
dc.subjectHeparinen_HK
dc.subjectStrokeen_HK
dc.subject.meshAtrial Fibrillation - drug therapy - pathology-
dc.subject.meshFibrinolytic Agents - administration and dosage - therapeutic use-
dc.subject.meshHeparin - administration and dosage - therapeutic use-
dc.subject.meshHeparin, Low-Molecular-Weight - administration and dosage - therapeutic use-
dc.subject.meshInfusions, Intravenous-
dc.titleLow molecular weight heparin versus unfractionated heparin for thromboprophylaxis in patients with acute atrial fibrillation: A randomized control trialen_HK
dc.typeArticleen_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/17482941.2011.567283en_HK
dc.identifier.pmid21517667en_HK
dc.identifier.scopuseid_2-s2.0-80052453860en_HK
dc.identifier.hkuros187310en_US
dc.identifier.hkuros201287-
dc.identifier.hkuros208713-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052453860&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage196en_HK
dc.identifier.epage198en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridJim, MH=6603860344en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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