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Article: Genetic epidemiology of age-related osteoporosis and its clinical applications

TitleGenetic epidemiology of age-related osteoporosis and its clinical applications
Authors
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.html
Citation
Nature Reviews Rheumatology, 2010, v. 6 n. 9, p. 507-517 How to Cite?
AbstractOsteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies. © 2010 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135218
ISSN
2015 Impact Factor: 10.531
2015 SCImago Journal Rankings: 2.728
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council of the Hong Kong Government
Osteoporosis Research Fund
University of Hong Kong
Funding Information:

This work was supported by the Research Grant Council of the Hong Kong Government, The Osteoporosis Research Fund and Matching Grant of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorXiao, SMen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2011-07-27T01:30:08Z-
dc.date.available2011-07-27T01:30:08Z-
dc.date.issued2010en_HK
dc.identifier.citationNature Reviews Rheumatology, 2010, v. 6 n. 9, p. 507-517en_HK
dc.identifier.issn1759-4790en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135218-
dc.description.abstractOsteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies. © 2010 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nrrheum/index.htmlen_HK
dc.relation.ispartofNature Reviews Rheumatologyen_HK
dc.subject.meshGenetic Linkage-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenomics-
dc.subject.meshHigh-Throughput Nucleotide Sequencing-
dc.subject.meshOsteoporosis - epidemiology - genetics - therapy-
dc.titleGenetic epidemiology of age-related osteoporosis and its clinical applicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1759-4790&volume=6&issue=9&spage=507&epage=517&date=2010&atitle=Genetic+epidemiology+of+age-related+osteoporosis+and+its+clinical+applications-
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nrrheum.2010.106en_HK
dc.identifier.pmid20683440-
dc.identifier.scopuseid_2-s2.0-77956286229en_HK
dc.identifier.hkuros187293en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956286229&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue9en_HK
dc.identifier.spage507en_HK
dc.identifier.epage517en_HK
dc.identifier.isiWOS:000281572800006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridXiao, SM=7402022586en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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