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Article: Ethnic difference of clinical vertebral fracture risk

TitleEthnic difference of clinical vertebral fracture risk
Authors
KeywordsAsian
Chinese
Fracture incidence
Osteoporosis
Vertebral fracture
Issue Date2012
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2012, v. 23 n. 3, p. 879-885 How to Cite?
AbstractVertebral fractures are the most common osteoporotic fractures. Data on the vertebral fracture risk in Asia remain sparse. This study observed that Hong Kong Chinese and Japanese populations have a less dramatic increase in hip fracture rates associated with age than Caucasians, but the vertebral fracture rates were higher, resulting in a high vertebral-to-hip fracture ratio. As a result, estimation of the absolute fracture risk for Asians may need to be readjusted for the higher clinical vertebral fracture rate. Introduction: Vertebral fractures are the most common osteoporotic fractures. Data on the vertebral fracture risk in Asia remain sparse. The aim of this study was to report the incidence of clinical vertebral fractures among the Chinese and to compare the vertebral-to-hip fracture risk to other ethnic groups. Methods: Four thousand, three hundred eighty-six community-dwelling Southern Chinese subjects (2,302 women and 1,810 men) aged 50 or above were recruited in the Hong Kong Osteoporosis Study since 1995. Baseline demographic characteristics and medical history were obtained. Subjects were followed annually for fracture outcomes with a structured questionnaire and verified by the computerized patient information system of the Hospital Authority of the Hong Kong Government. Only non-traumatic incident hip fractures and clinical vertebral fractures that received medical attention were included in the analysis. The incidence rates of clinical vertebral fractures and hip fractures were determined and compared to the published data of Swedish Caucasian and Japanese populations. Results: The mean age at baseline was 62 ± 8.2 years for women and 68 ± 10.3 years for men. The average duration of follow-up was 4.0 ± 2.8 (range, 1 to 14) years for a total of 14,733 person-years for the whole cohort. The incidence rate for vertebral fracture was 194/100,000 person-years in men and 508/100,000 person-years in women, respectively. For subjects above the age of 65, the clinical vertebral fracture and hip fracture rates were 299/100,000 and 332/100,000 person-years, respectively, in men, and 594/100,000 and 379/100,000 person-years, respectively, in women. Hong Kong Chinese and Japanese populations have a less dramatic increase in hip fracture rates associated with age than Caucasians. At the age of 65 or above, the hip fracture rates for Asian (Hong Kong Chinese and Japanese) men and women were less than half of that in Caucasians, but the vertebral fracture rate was higher in Asians, resulting in a high vertebral-to-hip fracture ratio. Conclusions: The incidences of vertebral and hip fractures, as well as the vertebral-to-hip fracture ratios vary in Asians and Caucasians. Estimation of the absolute fracture risk for Asians may need to be readjusted for the higher clinical vertebral fracture rate. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/135217
ISSN
2014 Impact Factor: 4.169
2014 SCImago Journal Rankings: 1.706
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong University Foundation
University of Hong Kong
KC Wong Education Foundation
Funding Information:

This study was funded by the Bone Health Fund of the Hong Kong University Foundation and the Osteoporosis Research Fund of the University of Hong Kong. SMCR is partly supported by the KC Wong Education Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorBow, CHen_HK
dc.contributor.authorCheung, Een_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorXiao, SMen_HK
dc.contributor.authorLoong, Cen_HK
dc.contributor.authorSoong, Cen_HK
dc.contributor.authorTan, KCen_HK
dc.contributor.authorLuckey, MMen_HK
dc.contributor.authorCauley, JAen_HK
dc.contributor.authorFujiwara, Sen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2011-07-27T01:30:08Z-
dc.date.available2011-07-27T01:30:08Z-
dc.date.issued2012en_HK
dc.identifier.citationOsteoporosis International, 2012, v. 23 n. 3, p. 879-885en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/135217-
dc.description.abstractVertebral fractures are the most common osteoporotic fractures. Data on the vertebral fracture risk in Asia remain sparse. This study observed that Hong Kong Chinese and Japanese populations have a less dramatic increase in hip fracture rates associated with age than Caucasians, but the vertebral fracture rates were higher, resulting in a high vertebral-to-hip fracture ratio. As a result, estimation of the absolute fracture risk for Asians may need to be readjusted for the higher clinical vertebral fracture rate. Introduction: Vertebral fractures are the most common osteoporotic fractures. Data on the vertebral fracture risk in Asia remain sparse. The aim of this study was to report the incidence of clinical vertebral fractures among the Chinese and to compare the vertebral-to-hip fracture risk to other ethnic groups. Methods: Four thousand, three hundred eighty-six community-dwelling Southern Chinese subjects (2,302 women and 1,810 men) aged 50 or above were recruited in the Hong Kong Osteoporosis Study since 1995. Baseline demographic characteristics and medical history were obtained. Subjects were followed annually for fracture outcomes with a structured questionnaire and verified by the computerized patient information system of the Hospital Authority of the Hong Kong Government. Only non-traumatic incident hip fractures and clinical vertebral fractures that received medical attention were included in the analysis. The incidence rates of clinical vertebral fractures and hip fractures were determined and compared to the published data of Swedish Caucasian and Japanese populations. Results: The mean age at baseline was 62 ± 8.2 years for women and 68 ± 10.3 years for men. The average duration of follow-up was 4.0 ± 2.8 (range, 1 to 14) years for a total of 14,733 person-years for the whole cohort. The incidence rate for vertebral fracture was 194/100,000 person-years in men and 508/100,000 person-years in women, respectively. For subjects above the age of 65, the clinical vertebral fracture and hip fracture rates were 299/100,000 and 332/100,000 person-years, respectively, in men, and 594/100,000 and 379/100,000 person-years, respectively, in women. Hong Kong Chinese and Japanese populations have a less dramatic increase in hip fracture rates associated with age than Caucasians. At the age of 65 or above, the hip fracture rates for Asian (Hong Kong Chinese and Japanese) men and women were less than half of that in Caucasians, but the vertebral fracture rate was higher in Asians, resulting in a high vertebral-to-hip fracture ratio. Conclusions: The incidences of vertebral and hip fractures, as well as the vertebral-to-hip fracture ratios vary in Asians and Caucasians. Estimation of the absolute fracture risk for Asians may need to be readjusted for the higher clinical vertebral fracture rate. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAsianen_HK
dc.subjectChineseen_HK
dc.subjectFracture incidenceen_HK
dc.subjectOsteoporosisen_HK
dc.subjectVertebral fractureen_HK
dc.titleEthnic difference of clinical vertebral fracture risken_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Ethnic difference of clinical vertebral fracture risk&title=Osteoporosis International&issn=0937941X&date=2012-03-01&volume=23&issue=3& spage=879&authors=C. H. Bow, E. Cheung, C. L. Cheung, <i>et al.</i>en_US
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailTan, KC: kcbtan@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityTan, KC=rp00402en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00198-011-1627-9en_HK
dc.identifier.pmid21461720-
dc.identifier.pmcidPMC3277693-
dc.identifier.scopuseid_2-s2.0-84857441688en_HK
dc.identifier.hkuros187292en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857441688&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage879en_HK
dc.identifier.epage885en_HK
dc.identifier.eissn1433-2965en_US
dc.identifier.isiWOS:000300251200009-
dc.publisher.placeUnited Kingdomen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridBow, CH=36055977600en_HK
dc.identifier.scopusauthoridCheung, E=8126979900en_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridXiao, SM=7402022586en_HK
dc.identifier.scopusauthoridLoong, C=36768353300en_HK
dc.identifier.scopusauthoridSoong, C=36946377400en_HK
dc.identifier.scopusauthoridTan, KC=8082703100en_HK
dc.identifier.scopusauthoridLuckey, MM=7003555781en_HK
dc.identifier.scopusauthoridCauley, JA=35373878900en_HK
dc.identifier.scopusauthoridFujiwara, S=7401827353en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike9125803-

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