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Article: Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes

TitleVitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes
Authors
Issue Date2011
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2011, v. 96 n. 5, p. E830-E835 How to Cite?
AbstractContext: Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. Objective: We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. Design, Setting, and Participants: We conducted a cross-sectional study of 280 patients (59% male, aged 68 ± 10 yr) with type 2 DM recruited in outpatient clinics during the winter period. Main Outcome Measure: We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively. Results: The mean serum 25(OH)D concentration was 25.00 ± 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D < 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = -0.018, 95% confidence interval (CI) -0.035 to -0.002, P = 0.032]. Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference -1.43%, 95% CI -2.31 to -0.55, P = 0.001) and CD133+/KDR+EPC counts (mean difference -0.12%, 95% CI -0.21 to -0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels. Conclusions: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM. Copyright © 2011 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/135212
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200907176063
Sun Chieh Yeh Heart Foundation
Vita Green Health Products Co., Ltd.
Funding Information:

This work was supported by the Committee of Research and Conference Grants (CRCG) Small Project Funding of the University of Hong Kong (Project 200907176063), the Sun Chieh Yeh Heart Foundation, and Vita Green Health Products Co., Ltd.

References

 

DC FieldValueLanguage
dc.contributor.authorYiu, YFen_HK
dc.contributor.authorChan, YHen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorWong, LYen_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorWong, EWKen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-07-27T01:30:02Z-
dc.date.available2011-07-27T01:30:02Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2011, v. 96 n. 5, p. E830-E835en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/135212-
dc.description.abstractContext: Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. Objective: We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. Design, Setting, and Participants: We conducted a cross-sectional study of 280 patients (59% male, aged 68 ± 10 yr) with type 2 DM recruited in outpatient clinics during the winter period. Main Outcome Measure: We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively. Results: The mean serum 25(OH)D concentration was 25.00 ± 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D < 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = -0.018, 95% confidence interval (CI) -0.035 to -0.002, P = 0.032]. Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference -1.43%, 95% CI -2.31 to -0.55, P = 0.001) and CD133+/KDR+EPC counts (mean difference -0.12%, 95% CI -0.21 to -0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels. Conclusions: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM. Copyright © 2011 by The Endocrine Society.en_HK
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - pathology - physiopathology-
dc.subject.meshEndothelial Cells - pathology-
dc.subject.meshEndothelium, Vascular - physiopathology-
dc.subject.meshStem Cells - pathology-
dc.subject.meshVitamin D Deficiency - pathology-
dc.titleVitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetesen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.2010-2212en_HK
dc.identifier.pmid21325459-
dc.identifier.scopuseid_2-s2.0-79955673023en_HK
dc.identifier.hkuros187098en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955673023&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96en_HK
dc.identifier.issue5en_HK
dc.identifier.spageE830en_HK
dc.identifier.epageE835en_HK
dc.identifier.isiWOS:000290210600010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYiu, YF=51666457500en_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridWong, LY=36097267000en_HK
dc.identifier.scopusauthoridLee, SWL=51665337800en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridWong, EWK=51666127000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike9218817-

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