File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Can a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial

TitleCan a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial
Authors
KeywordsAIDS
Body fat
Cholesterol
Highly active antiretroviral therapy
Low-fat diet
Issue Date2011
PublisherCSIRO, Publishing. The Journal's web site is located at http://www.publish.csiro.au/nid/164.htm
Citation
Sexual Health, 2011, v. 8 n. 1, p. 43-51 How to Cite?
AbstractBACKGROUND: HIV and highly active antiretroviral therapies have been associated with changes in individuals' lipid profiles and fat distribution (lipodystrophy). A pilot study was conducted for a randomised controlled trial to evaluate whether lipodystrophy in HIV patients can be controlled by adopting the low-fat and low-cholesterol diet or the modified Mediterranean diet. METHODS: Forty-eight HIV patients were randomised into two diet groups. Thirty-six (75%) completed the 1-year pilot study with regular dietetic consultations, during which time lipid levels, weight, body mass index and fat distribution were recorded. Differences between and within groups were determined. RESULTS: Undesirable body fat changes in the low-fat diet group included decreases in tricep skinfold (from 19.9 mm to 15.4 mm (P = 0.03)), hip circumference (from 93.6 cm to 91.7 cm (P = 0.01)) but a significant increase in waist-to-hip ratio (from 0.87 to 0.89 (P = 0.003)). Serum cholesterol increased significantly in the Mediterranean diet group at 9 and 12 months (from 4.6 to 5.06 mmol L(-1) (P = 0.03) and 5.12 mmol L(-1) (P = 0.01)) with no obvious change in the low-fat diet group. Serum triglyceride levels remained the same in the Mediterranean diet group, whereas it increased from 1.9 to 3.22 mmol L(-1) (P = 0.07) in the low-fat diet group. CONCLUSIONS: A Mediterranean diet seems to have an advantage over the low-fat diet in maintaining serum triglyceride levels and avoiding lipodystrophy, but this advantage was offset by a rise in cholesterol level. Several procedural and methodological issues were identified which must be rectified before a similar large-scale trial taking place.
Persistent Identifierhttp://hdl.handle.net/10722/135185
ISSN
2015 Impact Factor: 1.225
2015 SCImago Journal Rankings: 1.137
ISI Accession Number ID
Funding AgencyGrant Number
Council for the AIDS Trust Fund, Hong KongMSS087
Funding Information:

The authors thank the participants who enrolled in this study. We would also like to thank the medical and nursing staff of the AIDS Unit and the dietitians of the Dietetic Department at Queen Elizabeth Hospital for providing valuable advice and support throughout the study. Thanks also to Ms. Han Li and Ms. Athena Pak for their assistance with the statistical analysis and drawing graphs and tables; Professor ZhiXiu Lin is thanked for proofreading the script and for providing valuable comments. This study was supported fully by the Council for the AIDS Trust Fund, Hong Kong MSS087: Nutritional Assessment and Management of HIV Patients.

 

DC FieldValueLanguage
dc.contributor.authorNg, GWBen_US
dc.contributor.authorChan, UMSen_US
dc.contributor.authorLi, PCKen_US
dc.contributor.authorWong, WCWen_US
dc.date.accessioned2011-07-27T01:29:36Z-
dc.date.available2011-07-27T01:29:36Z-
dc.date.issued2011en_US
dc.identifier.citationSexual Health, 2011, v. 8 n. 1, p. 43-51en_US
dc.identifier.issn1448-5028-
dc.identifier.urihttp://hdl.handle.net/10722/135185-
dc.description.abstractBACKGROUND: HIV and highly active antiretroviral therapies have been associated with changes in individuals' lipid profiles and fat distribution (lipodystrophy). A pilot study was conducted for a randomised controlled trial to evaluate whether lipodystrophy in HIV patients can be controlled by adopting the low-fat and low-cholesterol diet or the modified Mediterranean diet. METHODS: Forty-eight HIV patients were randomised into two diet groups. Thirty-six (75%) completed the 1-year pilot study with regular dietetic consultations, during which time lipid levels, weight, body mass index and fat distribution were recorded. Differences between and within groups were determined. RESULTS: Undesirable body fat changes in the low-fat diet group included decreases in tricep skinfold (from 19.9 mm to 15.4 mm (P = 0.03)), hip circumference (from 93.6 cm to 91.7 cm (P = 0.01)) but a significant increase in waist-to-hip ratio (from 0.87 to 0.89 (P = 0.003)). Serum cholesterol increased significantly in the Mediterranean diet group at 9 and 12 months (from 4.6 to 5.06 mmol L(-1) (P = 0.03) and 5.12 mmol L(-1) (P = 0.01)) with no obvious change in the low-fat diet group. Serum triglyceride levels remained the same in the Mediterranean diet group, whereas it increased from 1.9 to 3.22 mmol L(-1) (P = 0.07) in the low-fat diet group. CONCLUSIONS: A Mediterranean diet seems to have an advantage over the low-fat diet in maintaining serum triglyceride levels and avoiding lipodystrophy, but this advantage was offset by a rise in cholesterol level. Several procedural and methodological issues were identified which must be rectified before a similar large-scale trial taking place.-
dc.languageengen_US
dc.publisherCSIRO, Publishing. The Journal's web site is located at http://www.publish.csiro.au/nid/164.htm-
dc.relation.ispartofSexual Healthen_US
dc.subjectAIDS-
dc.subjectBody fat-
dc.subjectCholesterol-
dc.subjectHighly active antiretroviral therapy-
dc.subjectLow-fat diet-
dc.subject.meshDiet, Fat-Restricted - statistics and numerical data-
dc.subject.meshDiet, Mediterranean - statistics and numerical data-
dc.subject.meshHIV-Associated Lipodystrophy Syndrome - diet therapy-
dc.subject.meshTriglycerides - blood-
dc.subject.meshCholesterol/blood-
dc.titleCan a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailWong, WCW: wongwcw@hku.hken_US
dc.identifier.authorityWong, WCW=rp01457en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1071/SH09065-
dc.identifier.pmid21371381-
dc.identifier.scopuseid_2-s2.0-79251624638-
dc.identifier.hkuros186463en_US
dc.identifier.volume8en_US
dc.identifier.issue1-
dc.identifier.spage43en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:000286518400009-
dc.publisher.placeAustralia-
dc.identifier.scopusauthoridNg, GWB=36894912000-
dc.identifier.scopusauthoridChan, UMS=6602540122-
dc.identifier.scopusauthoridLi, PCK=36068280500-
dc.identifier.scopusauthoridWong, WCW=25230779000-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats