File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1071/SH09065
- Scopus: eid_2-s2.0-79251624638
- PMID: 21371381
- WOS: WOS:000286518400009
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Can a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial
Title | Can a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial | ||||
---|---|---|---|---|---|
Authors | |||||
Keywords | AIDS Body fat Cholesterol Highly active antiretroviral therapy Low-fat diet | ||||
Issue Date | 2011 | ||||
Publisher | CSIRO, Publishing. The Journal's web site is located at http://www.publish.csiro.au/nid/164.htm | ||||
Citation | Sexual Health, 2011, v. 8 n. 1, p. 43-51 How to Cite? | ||||
Abstract | BACKGROUND: HIV and highly active antiretroviral therapies have been associated with changes in individuals' lipid profiles and fat distribution (lipodystrophy). A pilot study was conducted for a randomised controlled trial to evaluate whether lipodystrophy in HIV patients can be controlled by adopting the low-fat and low-cholesterol diet or the modified Mediterranean diet. METHODS: Forty-eight HIV patients were randomised into two diet groups. Thirty-six (75%) completed the 1-year pilot study with regular dietetic consultations, during which time lipid levels, weight, body mass index and fat distribution were recorded. Differences between and within groups were determined. RESULTS: Undesirable body fat changes in the low-fat diet group included decreases in tricep skinfold (from 19.9 mm to 15.4 mm (P = 0.03)), hip circumference (from 93.6 cm to 91.7 cm (P = 0.01)) but a significant increase in waist-to-hip ratio (from 0.87 to 0.89 (P = 0.003)). Serum cholesterol increased significantly in the Mediterranean diet group at 9 and 12 months (from 4.6 to 5.06 mmol L(-1) (P = 0.03) and 5.12 mmol L(-1) (P = 0.01)) with no obvious change in the low-fat diet group. Serum triglyceride levels remained the same in the Mediterranean diet group, whereas it increased from 1.9 to 3.22 mmol L(-1) (P = 0.07) in the low-fat diet group. CONCLUSIONS: A Mediterranean diet seems to have an advantage over the low-fat diet in maintaining serum triglyceride levels and avoiding lipodystrophy, but this advantage was offset by a rise in cholesterol level. Several procedural and methodological issues were identified which must be rectified before a similar large-scale trial taking place. | ||||
Persistent Identifier | http://hdl.handle.net/10722/135185 | ||||
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.527 | ||||
ISI Accession Number ID |
Funding Information: The authors thank the participants who enrolled in this study. We would also like to thank the medical and nursing staff of the AIDS Unit and the dietitians of the Dietetic Department at Queen Elizabeth Hospital for providing valuable advice and support throughout the study. Thanks also to Ms. Han Li and Ms. Athena Pak for their assistance with the statistical analysis and drawing graphs and tables; Professor ZhiXiu Lin is thanked for proofreading the script and for providing valuable comments. This study was supported fully by the Council for the AIDS Trust Fund, Hong Kong MSS087: Nutritional Assessment and Management of HIV Patients. |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, GWB | en_US |
dc.contributor.author | Chan, UMS | en_US |
dc.contributor.author | Li, PCK | en_US |
dc.contributor.author | Wong, WCW | en_US |
dc.date.accessioned | 2011-07-27T01:29:36Z | - |
dc.date.available | 2011-07-27T01:29:36Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Sexual Health, 2011, v. 8 n. 1, p. 43-51 | en_US |
dc.identifier.issn | 1448-5028 | - |
dc.identifier.uri | http://hdl.handle.net/10722/135185 | - |
dc.description.abstract | BACKGROUND: HIV and highly active antiretroviral therapies have been associated with changes in individuals' lipid profiles and fat distribution (lipodystrophy). A pilot study was conducted for a randomised controlled trial to evaluate whether lipodystrophy in HIV patients can be controlled by adopting the low-fat and low-cholesterol diet or the modified Mediterranean diet. METHODS: Forty-eight HIV patients were randomised into two diet groups. Thirty-six (75%) completed the 1-year pilot study with regular dietetic consultations, during which time lipid levels, weight, body mass index and fat distribution were recorded. Differences between and within groups were determined. RESULTS: Undesirable body fat changes in the low-fat diet group included decreases in tricep skinfold (from 19.9 mm to 15.4 mm (P = 0.03)), hip circumference (from 93.6 cm to 91.7 cm (P = 0.01)) but a significant increase in waist-to-hip ratio (from 0.87 to 0.89 (P = 0.003)). Serum cholesterol increased significantly in the Mediterranean diet group at 9 and 12 months (from 4.6 to 5.06 mmol L(-1) (P = 0.03) and 5.12 mmol L(-1) (P = 0.01)) with no obvious change in the low-fat diet group. Serum triglyceride levels remained the same in the Mediterranean diet group, whereas it increased from 1.9 to 3.22 mmol L(-1) (P = 0.07) in the low-fat diet group. CONCLUSIONS: A Mediterranean diet seems to have an advantage over the low-fat diet in maintaining serum triglyceride levels and avoiding lipodystrophy, but this advantage was offset by a rise in cholesterol level. Several procedural and methodological issues were identified which must be rectified before a similar large-scale trial taking place. | - |
dc.language | eng | en_US |
dc.publisher | CSIRO, Publishing. The Journal's web site is located at http://www.publish.csiro.au/nid/164.htm | - |
dc.relation.ispartof | Sexual Health | en_US |
dc.subject | AIDS | - |
dc.subject | Body fat | - |
dc.subject | Cholesterol | - |
dc.subject | Highly active antiretroviral therapy | - |
dc.subject | Low-fat diet | - |
dc.subject.mesh | Diet, Fat-Restricted - statistics and numerical data | - |
dc.subject.mesh | Diet, Mediterranean - statistics and numerical data | - |
dc.subject.mesh | HIV-Associated Lipodystrophy Syndrome - diet therapy | - |
dc.subject.mesh | Triglycerides - blood | - |
dc.subject.mesh | Cholesterol/blood | - |
dc.title | Can a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, WCW: wongwcw@hku.hk | en_US |
dc.identifier.authority | Wong, WCW=rp01457 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1071/SH09065 | - |
dc.identifier.pmid | 21371381 | - |
dc.identifier.scopus | eid_2-s2.0-79251624638 | - |
dc.identifier.hkuros | 186463 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 43 | en_US |
dc.identifier.epage | 51 | en_US |
dc.identifier.isi | WOS:000286518400009 | - |
dc.publisher.place | Australia | - |
dc.identifier.scopusauthorid | Ng, GWB=36894912000 | - |
dc.identifier.scopusauthorid | Chan, UMS=6602540122 | - |
dc.identifier.scopusauthorid | Li, PCK=36068280500 | - |
dc.identifier.scopusauthorid | Wong, WCW=25230779000 | - |
dc.identifier.issnl | 1448-5028 | - |