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Article: BOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation
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TitleBOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation
 
AuthorsLau, C1
Zhou, IY1
Cheung, MM1
Chan, KC1
Wu, EX1
 
KeywordsMonocrystalline iron oxide nanoparticle
Blood oxygenation
Brain blood vessel
Brain cortex
Functional magnetic resonance imaging
 
Issue Date2011
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2011, v. 6 n. 4 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0018914
 
AbstractBackground: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC and LGN's response temporal dynamics following short duration (1 s) visual stimulation. Methodology/Principal Findings: Experiments are performed at 7 tesla on Sprague Dawley rats stimulated in one eye with flashing light. Gradient-echo and spin-echo sequences are used to provide complementary information. An anatomical image is acquired from one rat after injection of monocrystalline iron oxide nanoparticles (MION), a blood vessel contrast agent. BOLD responses are concentrated in the contralateral SC and LGN. The SC BOLD signal measured with gradient-echo rises to 50% of maximum amplitude (PEAK) 0.2±0.2 s before the LGN signal (p<0.05). The LGN signal returns to 50% of PEAK 1.4±1.2 s before the SC signal (p<0.05). These results indicate the SC signal rises faster than the LGN signal but settles slower. Spin-echo results support these findings. The post-MION image shows the SC and LGN lie beneath large blood vessels. This subcortical vasculature is similar to that in the cortex, which also lies beneath large vessels. The LGN lies closer to the large vessels than much of the SC. Conclusions/Significance: The differences in response timing between SC and LGN are very similar to those between deep and shallow cortical layers following electrical stimulation, which are related to depth-dependent blood vessel dilation rates. This combined with the similarities in vasculature between subcortex and cortex suggest the SC and LGN timing differences are also related to depth-dependent dilation rates. This study shows for the first time that BOLD responses in the rat SC and LGN following short duration visual stimulation are temporally different. © 2011 Lau et al.
 
ISSN1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0018914
 
PubMed Central IDPMC3084720
 
ISI Accession Number IDWOS:000290024700035
Funding AgencyGrant Number
Hong Kong Research Grants CouncilGRF HKU 7793/08M
GRF HKU 7808/09 M
Funding Information:

This work was supported by the Hong Kong Research Grants Council (GRF HKU 7793/08M and GRF HKU 7808/09 M; http://www.ugc.edu.hk/eng/rgc/index.htm). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, C
 
dc.contributor.authorZhou, IY
 
dc.contributor.authorCheung, MM
 
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2011-07-27T01:28:13Z
 
dc.date.available2011-07-27T01:28:13Z
 
dc.date.issued2011
 
dc.description.abstractBackground: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC and LGN's response temporal dynamics following short duration (1 s) visual stimulation. Methodology/Principal Findings: Experiments are performed at 7 tesla on Sprague Dawley rats stimulated in one eye with flashing light. Gradient-echo and spin-echo sequences are used to provide complementary information. An anatomical image is acquired from one rat after injection of monocrystalline iron oxide nanoparticles (MION), a blood vessel contrast agent. BOLD responses are concentrated in the contralateral SC and LGN. The SC BOLD signal measured with gradient-echo rises to 50% of maximum amplitude (PEAK) 0.2±0.2 s before the LGN signal (p<0.05). The LGN signal returns to 50% of PEAK 1.4±1.2 s before the SC signal (p<0.05). These results indicate the SC signal rises faster than the LGN signal but settles slower. Spin-echo results support these findings. The post-MION image shows the SC and LGN lie beneath large blood vessels. This subcortical vasculature is similar to that in the cortex, which also lies beneath large vessels. The LGN lies closer to the large vessels than much of the SC. Conclusions/Significance: The differences in response timing between SC and LGN are very similar to those between deep and shallow cortical layers following electrical stimulation, which are related to depth-dependent blood vessel dilation rates. This combined with the similarities in vasculature between subcortex and cortex suggest the SC and LGN timing differences are also related to depth-dependent dilation rates. This study shows for the first time that BOLD responses in the rat SC and LGN following short duration visual stimulation are temporally different. © 2011 Lau et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2011, v. 6 n. 4 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0018914
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0018914
 
dc.identifier.hkuros186445
 
dc.identifier.isiWOS:000290024700035
Funding AgencyGrant Number
Hong Kong Research Grants CouncilGRF HKU 7793/08M
GRF HKU 7808/09 M
Funding Information:

This work was supported by the Hong Kong Research Grants Council (GRF HKU 7793/08M and GRF HKU 7808/09 M; http://www.ugc.edu.hk/eng/rgc/index.htm). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
dc.identifier.issn1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3084720
 
dc.identifier.pmid21559482
 
dc.identifier.scopuseid_2-s2.0-79955709177
 
dc.identifier.urihttp://hdl.handle.net/10722/135089
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectMonocrystalline iron oxide nanoparticle
 
dc.subjectBlood oxygenation
 
dc.subjectBrain blood vessel
 
dc.subjectBrain cortex
 
dc.subjectFunctional magnetic resonance imaging
 
dc.titleBOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong