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Article: Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
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TitleGold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
 
AuthorsLum, CT1
Huo, L1
Sun, RWY1
Li, M1
Kung, HF2
Che, CM1
Lin, MCM1 2
 
Issue Date2011
 
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0284186x.asp
 
CitationActa Oncologica, 2011, v. 50 n. 5, p. 719-726 [How to Cite?]
DOI: http://dx.doi.org/10.3109/0284186X.2010.537693
 
AbstractBackground. Gold(III) meso-tetraphenylporphyrin (gold-1a) has previously been shown to prolong the survival of hepatocellular carcinoma (HCC)-bearing rats and nasopharyngeal carcinoma (NPC) metastasis-bearing mice. It has also been proved to inhibit the tumor growth of mice bearing NPC, neuroblastoma and colon carcinoma. Mechanistically, gold-1a induces apoptosis, inhibits cell migration and invasion. In this study the efficacies of gold-1a in inhibiting melanoma and angiogenesis were investigated. Material and methods. A mouse melanoma model was used to investigate the efficacy of gold-1a in inhibiting angiogenesis, tumor growth and prolonging the survival of the tumor-bearing animals. The model was established by inoculation of 2 × - 10 5 B16-F1 mouse melanoma cells into the right back flanks of the mice by subcutaneous inoculation. When the tumors grew to 0.2-0.4 cm in diameters, the mice were treated with gold-1a, solvent control or dacarbazine (DTIC) for comparison. Tumor sizes and animal survivals were monitored throughout the experiment. Tumor tissues were collected and immunohistochemically stained with CD31 antibodies for evaluation of intra-tumoral microvessel density (iMVD). Results and conclusion. Gold-1a significantly prolonged the survivals, reduced angiogenesis and tumor growth rates of melanoma-bearing mice. The compound induced necrosis and apoptosis in the mouse melanoma tissues. Gold-1a also downregulated the expression of genes playing roles in angiogenesis. Gold-1a may potentially be used to treat melanoma in patients. © 2011 Informa Healthcare.
 
ISSN0284-186X
2012 Impact Factor: 2.867
2012 SCImago Journal Rankings: 1.176
 
DOIhttp://dx.doi.org/10.3109/0284186X.2010.537693
 
ISI Accession Number IDWOS:000290631600015
Funding AgencyGrant Number
UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07M
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01), RGC (HKU7705/07M to MCL) of the Hong Kong Special Administrative Region, China. There are no financial disclosures from any authors.

 
ReferencesReferences in Scopus
 
GrantsInstitute of molecular technology for drug discovery and synthesis
 
DC FieldValue
dc.contributor.authorLum, CT
 
dc.contributor.authorHuo, L
 
dc.contributor.authorSun, RWY
 
dc.contributor.authorLi, M
 
dc.contributor.authorKung, HF
 
dc.contributor.authorChe, CM
 
dc.contributor.authorLin, MCM
 
dc.date.accessioned2011-07-27T01:27:07Z
 
dc.date.available2011-07-27T01:27:07Z
 
dc.date.issued2011
 
dc.description.abstractBackground. Gold(III) meso-tetraphenylporphyrin (gold-1a) has previously been shown to prolong the survival of hepatocellular carcinoma (HCC)-bearing rats and nasopharyngeal carcinoma (NPC) metastasis-bearing mice. It has also been proved to inhibit the tumor growth of mice bearing NPC, neuroblastoma and colon carcinoma. Mechanistically, gold-1a induces apoptosis, inhibits cell migration and invasion. In this study the efficacies of gold-1a in inhibiting melanoma and angiogenesis were investigated. Material and methods. A mouse melanoma model was used to investigate the efficacy of gold-1a in inhibiting angiogenesis, tumor growth and prolonging the survival of the tumor-bearing animals. The model was established by inoculation of 2 × - 10 5 B16-F1 mouse melanoma cells into the right back flanks of the mice by subcutaneous inoculation. When the tumors grew to 0.2-0.4 cm in diameters, the mice were treated with gold-1a, solvent control or dacarbazine (DTIC) for comparison. Tumor sizes and animal survivals were monitored throughout the experiment. Tumor tissues were collected and immunohistochemically stained with CD31 antibodies for evaluation of intra-tumoral microvessel density (iMVD). Results and conclusion. Gold-1a significantly prolonged the survivals, reduced angiogenesis and tumor growth rates of melanoma-bearing mice. The compound induced necrosis and apoptosis in the mouse melanoma tissues. Gold-1a also downregulated the expression of genes playing roles in angiogenesis. Gold-1a may potentially be used to treat melanoma in patients. © 2011 Informa Healthcare.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationActa Oncologica, 2011, v. 50 n. 5, p. 719-726 [How to Cite?]
DOI: http://dx.doi.org/10.3109/0284186X.2010.537693
 
dc.identifier.doihttp://dx.doi.org/10.3109/0284186X.2010.537693
 
dc.identifier.epage726
 
dc.identifier.hkuros187491
 
dc.identifier.hkuros186306
 
dc.identifier.isiWOS:000290631600015
Funding AgencyGrant Number
UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07M
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01), RGC (HKU7705/07M to MCL) of the Hong Kong Special Administrative Region, China. There are no financial disclosures from any authors.

 
dc.identifier.issn0284-186X
2012 Impact Factor: 2.867
2012 SCImago Journal Rankings: 1.176
 
dc.identifier.issue5
 
dc.identifier.pmid21110776
 
dc.identifier.scopuseid_2-s2.0-79956150497
 
dc.identifier.spage719
 
dc.identifier.urihttp://hdl.handle.net/10722/135044
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0284186x.asp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofActa Oncologica
 
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis
 
dc.relation.referencesReferences in Scopus
 
dc.rightsActa Oncologica. Copyright © Informa Healthcare.
 
dc.subject.meshCarcinoma - drug therapy - mortality
 
dc.subject.meshMelanoma, Experimental - drug therapy - mortality
 
dc.subject.meshMetalloporphyrins - pharmacology - therapeutic use
 
dc.subject.meshNeoplasm Transplantation
 
dc.subject.meshNeovascularization, Pathologic - prevention and control
 
dc.titleGold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
 
dc.typeArticle
 
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<contributor.author>Che, CM</contributor.author>
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Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  2. Chinese University of Hong Kong