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Article: Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis

TitleGold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis
Authors
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0284186x.asp
Citation
Acta Oncologica, 2011, v. 50 n. 5, p. 719-726 How to Cite?
AbstractBackground. Gold(III) meso-tetraphenylporphyrin (gold-1a) has previously been shown to prolong the survival of hepatocellular carcinoma (HCC)-bearing rats and nasopharyngeal carcinoma (NPC) metastasis-bearing mice. It has also been proved to inhibit the tumor growth of mice bearing NPC, neuroblastoma and colon carcinoma. Mechanistically, gold-1a induces apoptosis, inhibits cell migration and invasion. In this study the efficacies of gold-1a in inhibiting melanoma and angiogenesis were investigated. Material and methods. A mouse melanoma model was used to investigate the efficacy of gold-1a in inhibiting angiogenesis, tumor growth and prolonging the survival of the tumor-bearing animals. The model was established by inoculation of 2 × - 10 5 B16-F1 mouse melanoma cells into the right back flanks of the mice by subcutaneous inoculation. When the tumors grew to 0.2-0.4 cm in diameters, the mice were treated with gold-1a, solvent control or dacarbazine (DTIC) for comparison. Tumor sizes and animal survivals were monitored throughout the experiment. Tumor tissues were collected and immunohistochemically stained with CD31 antibodies for evaluation of intra-tumoral microvessel density (iMVD). Results and conclusion. Gold-1a significantly prolonged the survivals, reduced angiogenesis and tumor growth rates of melanoma-bearing mice. The compound induced necrosis and apoptosis in the mouse melanoma tissues. Gold-1a also downregulated the expression of genes playing roles in angiogenesis. Gold-1a may potentially be used to treat melanoma in patients. © 2011 Informa Healthcare.
Persistent Identifierhttp://hdl.handle.net/10722/135044
ISSN
2015 Impact Factor: 3.73
2015 SCImago Journal Rankings: 1.499
ISI Accession Number ID
Funding AgencyGrant Number
UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07M
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01), RGC (HKU7705/07M to MCL) of the Hong Kong Special Administrative Region, China. There are no financial disclosures from any authors.

References
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DC FieldValueLanguage
dc.contributor.authorLum, CTen_HK
dc.contributor.authorHuo, Len_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorLin, MCMen_HK
dc.date.accessioned2011-07-27T01:27:07Z-
dc.date.available2011-07-27T01:27:07Z-
dc.date.issued2011en_HK
dc.identifier.citationActa Oncologica, 2011, v. 50 n. 5, p. 719-726en_HK
dc.identifier.issn0284-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/135044-
dc.description.abstractBackground. Gold(III) meso-tetraphenylporphyrin (gold-1a) has previously been shown to prolong the survival of hepatocellular carcinoma (HCC)-bearing rats and nasopharyngeal carcinoma (NPC) metastasis-bearing mice. It has also been proved to inhibit the tumor growth of mice bearing NPC, neuroblastoma and colon carcinoma. Mechanistically, gold-1a induces apoptosis, inhibits cell migration and invasion. In this study the efficacies of gold-1a in inhibiting melanoma and angiogenesis were investigated. Material and methods. A mouse melanoma model was used to investigate the efficacy of gold-1a in inhibiting angiogenesis, tumor growth and prolonging the survival of the tumor-bearing animals. The model was established by inoculation of 2 × - 10 5 B16-F1 mouse melanoma cells into the right back flanks of the mice by subcutaneous inoculation. When the tumors grew to 0.2-0.4 cm in diameters, the mice were treated with gold-1a, solvent control or dacarbazine (DTIC) for comparison. Tumor sizes and animal survivals were monitored throughout the experiment. Tumor tissues were collected and immunohistochemically stained with CD31 antibodies for evaluation of intra-tumoral microvessel density (iMVD). Results and conclusion. Gold-1a significantly prolonged the survivals, reduced angiogenesis and tumor growth rates of melanoma-bearing mice. The compound induced necrosis and apoptosis in the mouse melanoma tissues. Gold-1a also downregulated the expression of genes playing roles in angiogenesis. Gold-1a may potentially be used to treat melanoma in patients. © 2011 Informa Healthcare.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0284186x.aspen_HK
dc.relation.ispartofActa Oncologicaen_HK
dc.rightsActa Oncologica. Copyright © Informa Healthcare.-
dc.subject.meshCarcinoma - drug therapy - mortality-
dc.subject.meshMelanoma, Experimental - drug therapy - mortality-
dc.subject.meshMetalloporphyrins - pharmacology - therapeutic use-
dc.subject.meshNeoplasm Transplantation-
dc.subject.meshNeovascularization, Pathologic - prevention and control-
dc.titleGold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailLum, CT:ctlum@graduate.hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLum, CT=rp00757en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/0284186X.2010.537693en_HK
dc.identifier.pmid21110776-
dc.identifier.scopuseid_2-s2.0-79956150497en_HK
dc.identifier.hkuros187491en_US
dc.identifier.hkuros186306-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956150497&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue5en_HK
dc.identifier.spage719en_HK
dc.identifier.epage726en_HK
dc.identifier.isiWOS:000290631600015-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridLum, CT=7006889374en_HK
dc.identifier.scopusauthoridHuo, L=9275343500en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridLi, M=36067425800en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK

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