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Article: A cascade of irx1a and irx2a controls shh expression during retinogenesis

TitleA cascade of irx1a and irx2a controls shh expression during retinogenesis
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Citation
Developmental Dynamics, 2010, v. 239 n. 12, p. 3204-3214 How to Cite?
AbstractIn animal retina, hedgehog expression drives waves of neurogenesis, but genetic programs that control its expression during retinal neurogenesis are poorly elucidated. We have previously reported that irx1a is required for propagation of the sonic hedgehog (shh) expression waves in developing zebrafish retina. Here, we found that irx2a is expressed in the developing retina and that knockdown of irx2a results in a retinal phenotype strikingly similar to that of irx1a morphants. The expression of irx2a in retina ganglion cells was shown to be irx1a- and ath5-dependent suggesting that irx1a and ath5 are transcriptional regulators of irx2a. Furthermore, irx2a expression could rescue impaired propagation of shh waves in irx1a morphants. Together, these observations suggest that Irx2 functions downstream of irx1a to control shh expression in the retina. We proposed a novel transcriptional cascade of ath5-irx1a-irx2a in the regulation of hedgehog waves during vertebrate retinal development. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135021
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the Hong Kong SAR, ChinaCityU 160107
Canadian Institutes of Health Research
National Science Foundation of China90919034
Funding Information:

Grant sponsor: Research Grants Council of the Hong Kong SAR, China; Grant number: 160107; Grant sponsor: Canadian Institutes of Health Research; Grant sponsor: National Science Foundation of China; Grant number: 90919034.

 

DC FieldValueLanguage
dc.contributor.authorChoy, SWen_US
dc.contributor.authorCheng, CWen_US
dc.contributor.authorLee, STen_US
dc.contributor.authorLi, VWTen_US
dc.contributor.authorHui, MNYen_US
dc.contributor.authorHui, CCen_US
dc.contributor.authorLiu, Den_US
dc.contributor.authorCheng, SH-
dc.date.accessioned2011-07-27T01:26:03Z-
dc.date.available2011-07-27T01:26:03Z-
dc.date.issued2010en_US
dc.identifier.citationDevelopmental Dynamics, 2010, v. 239 n. 12, p. 3204-3214en_US
dc.identifier.issn1058-8388en_US
dc.identifier.urihttp://hdl.handle.net/10722/135021-
dc.description.abstractIn animal retina, hedgehog expression drives waves of neurogenesis, but genetic programs that control its expression during retinal neurogenesis are poorly elucidated. We have previously reported that irx1a is required for propagation of the sonic hedgehog (shh) expression waves in developing zebrafish retina. Here, we found that irx2a is expressed in the developing retina and that knockdown of irx2a results in a retinal phenotype strikingly similar to that of irx1a morphants. The expression of irx2a in retina ganglion cells was shown to be irx1a- and ath5-dependent suggesting that irx1a and ath5 are transcriptional regulators of irx2a. Furthermore, irx2a expression could rescue impaired propagation of shh waves in irx1a morphants. Together, these observations suggest that Irx2 functions downstream of irx1a to control shh expression in the retina. We proposed a novel transcriptional cascade of ath5-irx1a-irx2a in the regulation of hedgehog waves during vertebrate retinal development. © 2010 Wiley-Liss, Inc.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417-
dc.relation.ispartofDevelopmental Dynamicsen_US
dc.rightsDevelopmental Dynamics. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshHomeodomain Proteins - genetics - metabolism-
dc.subject.meshRetina - embryology-
dc.subject.meshRetinal Ganglion Cells - cytology-
dc.subject.meshTranscription Factors - genetics - metabolism-
dc.subject.meshZebrafish Proteins - genetics - metabolism-
dc.titleA cascade of irx1a and irx2a controls shh expression during retinogenesisen_US
dc.typeArticleen_US
dc.identifier.emailCheng, CW: primer@hkucc.hku.hken_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/dvdy.22462-
dc.identifier.pmid21046643-
dc.identifier.scopuseid_2-s2.0-78649698183-
dc.identifier.hkuros188847en_US
dc.identifier.volume239en_US
dc.identifier.issue12-
dc.identifier.spage3204en_US
dc.identifier.epage3214en_US
dc.identifier.isiWOS:000284783100007-

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