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Article: Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in Southern Chinese

TitleIdentification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in Southern Chinese
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 1 How to Cite?
Abstract
Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin. The etiology of NPC is complex and includes multiple genetic and environmental factors. We employed case-control analysis to study the association of chromosome 6p regions with NPC. In total, 360 subjects and 360 healthy controls were included, and 233 single nucleotide polymorphisms (SNPs) on 6p were examined. Significant single-marker associations were found for SNPs rs2267633 (p = 4.49610 -5), rs2076483 (most significant, p = 3.36610 -5), and rs29230 (p = 1.43610 -4). The highly associated genes were the gamma-amino butyric acid B receptor 1 (GABBR1), human leukocyte antigen (HLA-A), and HLA complex group 9 (HCG9). Haplotypic associations were found for haplotypes AAA (located within GABBR1, p-value = 6.46610 -5) and TT (located within HLA-A, p = 0.0014). Further investigation of the homozygous genotype frequencies between cases and controls suggested that micro-deletion regions occur in GABBR1 and neural precursor cell expressed developmentally down-regulated 9 (NEDD9). Quantitative real-time polymerase chain reaction (qPCR) using 11 pairs of NPC biopsy samples confirmed the significant decline in GABBR1 and NEDD9 mRNA expression in the cancer tissues compared to the adjacent non-tumor tissue (p<0.05). Our study demonstrates that multiple chromosome 6p susceptibility loci contribute to the risk of NPC, possibly though GABBR1 and NEDD9 loss of function. © 2011 Li et al.
Persistent Identifierhttp://hdl.handle.net/10722/135019
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases (RFCID)08070652
AO Foundation (AOSPINE)AOSBRC-07-02
Funding Information:

The study is supported by a grant from the Research Fund for the Control of Infectious Diseases (RFCID: http://www.fhb.gov.hk/grants/english/funds/funds_rfcid/funds_rfcid_abt/funds_rfcid_abt.html) (no. 08070652, YQS) and AO Foundation (AOSPINE (AOSBRC-07-02; http://www.aospine.org/history.aspx). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorFu, Len_HK
dc.contributor.authorWong, AMGen_HK
dc.contributor.authorFan, YHen_HK
dc.contributor.authorLi, MXen_HK
dc.contributor.authorBei, JXen_HK
dc.contributor.authorJia, WHen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorChua, Den_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2011-07-27T01:26:02Z-
dc.date.available2011-07-27T01:26:02Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 1en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135019-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin. The etiology of NPC is complex and includes multiple genetic and environmental factors. We employed case-control analysis to study the association of chromosome 6p regions with NPC. In total, 360 subjects and 360 healthy controls were included, and 233 single nucleotide polymorphisms (SNPs) on 6p were examined. Significant single-marker associations were found for SNPs rs2267633 (p = 4.49610 -5), rs2076483 (most significant, p = 3.36610 -5), and rs29230 (p = 1.43610 -4). The highly associated genes were the gamma-amino butyric acid B receptor 1 (GABBR1), human leukocyte antigen (HLA-A), and HLA complex group 9 (HCG9). Haplotypic associations were found for haplotypes AAA (located within GABBR1, p-value = 6.46610 -5) and TT (located within HLA-A, p = 0.0014). Further investigation of the homozygous genotype frequencies between cases and controls suggested that micro-deletion regions occur in GABBR1 and neural precursor cell expressed developmentally down-regulated 9 (NEDD9). Quantitative real-time polymerase chain reaction (qPCR) using 11 pairs of NPC biopsy samples confirmed the significant decline in GABBR1 and NEDD9 mRNA expression in the cancer tissues compared to the adjacent non-tumor tissue (p<0.05). Our study demonstrates that multiple chromosome 6p susceptibility loci contribute to the risk of NPC, possibly though GABBR1 and NEDD9 loss of function. © 2011 Li et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAllelic Imbalance-
dc.subject.meshChina - epidemiology-
dc.subject.meshChromosomes, Human, Pair 6 - genetics-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshNasopharyngeal Neoplasms - genetics-
dc.titleIdentification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in Southern Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailFu, L: gracelfu@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailChua, D: dttchua@hkucc.hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.authorityFu, L=rp01435en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityChua, D=rp00415en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0014562en_HK
dc.identifier.pmid21283797-
dc.identifier.pmcidPMC3024318-
dc.identifier.scopuseid_2-s2.0-79251649127en_HK
dc.identifier.hkuros188460en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251649127&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spagee14562en_US
dc.identifier.epagee14562en_US
dc.identifier.isiWOS:000286522200005-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectFine mapping candidate loci for nasopharyngeal carcinoma (NPC) in southern Chinese specifically linked to EBV aetiopathogenesis-
dc.identifier.scopusauthoridLi, Y=36078298200en_HK
dc.identifier.scopusauthoridFu, L=22979236700en_HK
dc.identifier.scopusauthoridWong, AMG=37462381500en_HK
dc.identifier.scopusauthoridFan, YH=37461378000en_HK
dc.identifier.scopusauthoridLi, MX=35205389900en_HK
dc.identifier.scopusauthoridBei, JX=22949916100en_HK
dc.identifier.scopusauthoridJia, WH=26422262500en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridChua, D=7006773480en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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