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Article: Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?

TitleNeurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?
Authors
KeywordsAge-related macular degeneration
Alzheimer's disease
Glaucoma
Inner nuclear layer
Neurodegeneration
Retina
Retinal ganglion cells
Issue Date2012
PublisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/
Citation
Age, 2012, v. 34 n. 3, p. 633-649 How to Cite?
AbstractAlzheimer's disease (AD) is an age-related progressive neurodegenerative disease commonly found among elderly. In addition to cognitive and behavioral deficits, vision abnormalities are prevalent in AD patients. Recent studies investigating retinal changes in AD double-transgenic mice have shown altered processing of amyloid precursor protein and accumulation of β-amyloid peptides in neurons of retinal ganglion cell layer (RGCL) and inner nuclear layer (INL). Apoptotic cells were also detected in the RGCL. Thus, the pathophysiological changes of retinas in AD patients are possibly resembled by AD transgenic models. The retina is a simple model of the brain in the sense that some pathological changes and therapeutic strategies from the retina may be observed or applicable to the brain. Furthermore, it is also possible to advance our understanding of pathological mechanisms in other retinal degenerative diseases. Therefore, studying AD-related retinal degeneration is a promising way for the investigation on (1) AD pathologies and therapies that would eventually benefit the brain and (2) cellular mechanisms in other retinal degenerations such as glaucoma and age-related macular degeneration. This review will highlight the efforts on retinal degenerative research using AD transgenic mouse models. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/135016
ISSN
2014 Impact Factor: 3.390
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
HKU Alzheimer's Disease Research Network under Strategic Research Theme on Healthy Aging
Strategic Research Theme on Drug Discovery
Azalea
HKU20097176185
Funding Information:

Research in this laboratory is partly supported by HKU Alzheimer's Disease Research Network under Strategic Research Theme on Healthy Aging, Strategic Research Theme on Drug Discovery, Azalea (1972) Endowment Fund, and HKU Small Project Fund (20097176185).

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DC FieldValueLanguage
dc.contributor.authorChiu, Ken_HK
dc.contributor.authorChan, TFen_HK
dc.contributor.authorWu, Aen_HK
dc.contributor.authorLeung, IYPen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2011-07-27T01:25:51Z-
dc.date.available2011-07-27T01:25:51Z-
dc.date.issued2012en_HK
dc.identifier.citationAge, 2012, v. 34 n. 3, p. 633-649en_HK
dc.identifier.issn0161-9152en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135016-
dc.description.abstractAlzheimer's disease (AD) is an age-related progressive neurodegenerative disease commonly found among elderly. In addition to cognitive and behavioral deficits, vision abnormalities are prevalent in AD patients. Recent studies investigating retinal changes in AD double-transgenic mice have shown altered processing of amyloid precursor protein and accumulation of β-amyloid peptides in neurons of retinal ganglion cell layer (RGCL) and inner nuclear layer (INL). Apoptotic cells were also detected in the RGCL. Thus, the pathophysiological changes of retinas in AD patients are possibly resembled by AD transgenic models. The retina is a simple model of the brain in the sense that some pathological changes and therapeutic strategies from the retina may be observed or applicable to the brain. Furthermore, it is also possible to advance our understanding of pathological mechanisms in other retinal degenerative diseases. Therefore, studying AD-related retinal degeneration is a promising way for the investigation on (1) AD pathologies and therapies that would eventually benefit the brain and (2) cellular mechanisms in other retinal degenerations such as glaucoma and age-related macular degeneration. This review will highlight the efforts on retinal degenerative research using AD transgenic mouse models. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/en_HK
dc.relation.ispartofAgeen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAge-related macular degenerationen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectGlaucomaen_HK
dc.subjectInner nuclear layeren_HK
dc.subjectNeurodegenerationen_HK
dc.subjectRetinaen_HK
dc.subjectRetinal ganglion cellsen_HK
dc.titleNeurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Neurodegeneration of the retina in mouse models of Alzheimer’s disease: what can we learn from the retina?&title=AGE&issn=01619152&date=2011-05-11& spage=1&authors=Kin Chiu, Tin-Fung Chan, Andrew Wu, <i>et al.</i>en_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11357-011-9260-2en_HK
dc.identifier.pmid21559868-
dc.identifier.pmcidPMC3337933-
dc.identifier.scopuseid_2-s2.0-84863717137en_HK
dc.identifier.hkuros186973en_US
dc.identifier.hkuros199701-
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dc.identifier.volume34-
dc.identifier.issue3-
dc.identifier.spage1en_HK
dc.identifier.spage633-
dc.identifier.epage17en_HK
dc.identifier.epage649-
dc.identifier.eissn1574-4647en_US
dc.identifier.isiWOS:000303507400010-
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridChiu, K=15076970500en_HK
dc.identifier.scopusauthoridChan, TF=37118537600en_HK
dc.identifier.scopusauthoridWu, A=37119578800en_HK
dc.identifier.scopusauthoridLeung, IYP=37119139600en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.citeulike9313839-

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