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Article: The 53BP1-EXPAND1 connection in chromatin structure regulation.

TitleThe 53BP1-EXPAND1 connection in chromatin structure regulation.
Authors
Keywords53Bp1
Chromatin
Expand1
Mum1
Issue Date2010
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/nucleus/
Citation
Nucleus (Austin, Tex.), 2010, v. 1 n. 6, p. 472-474 How to Cite?
AbstractThe mammalian interphase chromatin responds to DNA damages by altering the compactness of its architecture, thereby permitting local access of DNA repair machineries. Adding to the cellular strategies of chromatin remodeling following DNA damage, our recent work identified the 53BP1-EXPAND1 module in promoting chromatin dynamics in response to DNA double-strand breaks. Endowed with a nucleosome-binding PWWP domain, EXPAND1 tethers to the chromatin where it is involved in maintaining basal chromatin accessibility in unperturbed cells. Interestingly, through its direct interaction with the DNA damage mediator protein 53BP1, EXPAND1 accumulates at the damage-modified chromatin and triggers its further decondensation. These observations, together with the fact that EXPAND 1 promotes cell survival following DNA damage, suggest that the chromatin-bound factor may facilitate DNA repair by regulating the organization of chromatin structure.
Persistent Identifierhttp://hdl.handle.net/10722/135013
ISSN
2015 SCImago Journal Rankings: 1.276
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSy, SMen_HK
dc.contributor.authorChen, Jen_HK
dc.contributor.authorHuen, MSen_HK
dc.date.accessioned2011-07-27T01:25:49Z-
dc.date.available2011-07-27T01:25:49Z-
dc.date.issued2010en_HK
dc.identifier.citationNucleus (Austin, Tex.), 2010, v. 1 n. 6, p. 472-474en_HK
dc.identifier.issn1949-1042en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135013-
dc.description.abstractThe mammalian interphase chromatin responds to DNA damages by altering the compactness of its architecture, thereby permitting local access of DNA repair machineries. Adding to the cellular strategies of chromatin remodeling following DNA damage, our recent work identified the 53BP1-EXPAND1 module in promoting chromatin dynamics in response to DNA double-strand breaks. Endowed with a nucleosome-binding PWWP domain, EXPAND1 tethers to the chromatin where it is involved in maintaining basal chromatin accessibility in unperturbed cells. Interestingly, through its direct interaction with the DNA damage mediator protein 53BP1, EXPAND1 accumulates at the damage-modified chromatin and triggers its further decondensation. These observations, together with the fact that EXPAND 1 promotes cell survival following DNA damage, suggest that the chromatin-bound factor may facilitate DNA repair by regulating the organization of chromatin structure.en_HK
dc.languageengen_US
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/nucleus/-
dc.relation.ispartofNucleus (Austin, Tex.)en_HK
dc.subject53Bp1-
dc.subjectChromatin-
dc.subjectExpand1-
dc.subjectMum1-
dc.subject.meshChromatin - metabolism-
dc.subject.meshChromatin Assembly and Disassembly - genetics-
dc.subject.meshChromosomal Proteins, Non-Histone - metabolism-
dc.subject.meshDNA Breaks, Double-Stranded-
dc.subject.meshIntracellular Signaling Peptides and Proteins - metabolism-
dc.titleThe 53BP1-EXPAND1 connection in chromatin structure regulation.en_HK
dc.typeArticleen_HK
dc.identifier.emailHuen, MS:huen.michael@hku.hken_HK
dc.identifier.authorityHuen, MS=rp01336en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4161/nucl.1.6.13059-
dc.identifier.pmid21327088en_HK
dc.identifier.pmcidPMC3027048-
dc.identifier.scopuseid_2-s2.0-78549254849en_HK
dc.identifier.hkuros186733en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78549254849&selection=ref&src=s&origin=recordpage-
dc.identifier.volume1en_HK
dc.identifier.issue6en_HK
dc.identifier.spage472en_HK
dc.identifier.epage474en_HK
dc.identifier.isiWOS:000208668700003-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridSy, SM=54901413200en_HK
dc.identifier.scopusauthoridChen, J=54900803600en_HK
dc.identifier.scopusauthoridHuen, MS=23004751500en_HK

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