Article: The 53BP1-EXPAND1 connection in chromatin structure regulation.

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Publisher Website: 10.4161/nucl.1.6.13059
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Title	The 53BP1-EXPAND1 connection in chromatin structure regulation.
Authors	Sy, SM Chen, J2 Huen, MS1
Keywords	53Bp1 Chromatin Expand1 Mum1
Issue Date	2010
Publisher	Landes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/nucleus/
Citation	Nucleus (Austin, Tex.), 2010, v. 1 n. 6, p. 472-474 [How to Cite?] DOI: http://dx.doi.org/10.4161/nucl.1.6.13059
Abstract	The mammalian interphase chromatin responds to DNA damages by altering the compactness of its architecture, thereby permitting local access of DNA repair machineries. Adding to the cellular strategies of chromatin remodeling following DNA damage, our recent work identified the 53BP1-EXPAND1 module in promoting chromatin dynamics in response to DNA double-strand breaks. Endowed with a nucleosome-binding PWWP domain, EXPAND1 tethers to the chromatin where it is involved in maintaining basal chromatin accessibility in unperturbed cells. Interestingly, through its direct interaction with the DNA damage mediator protein 53BP1, EXPAND1 accumulates at the damage-modified chromatin and triggers its further decondensation. These observations, together with the fact that EXPAND 1 promotes cell survival following DNA damage, suggest that the chromatin-bound factor may facilitate DNA repair by regulating the organization of chromatin structure.
ISSN	1949-1042
DOI	http://dx.doi.org/10.4161/nucl.1.6.13059
PubMed Central ID	PMC3027048
References	References in Scopus

DC Field	Value
dc.contributor.author	Sy, SM
dc.contributor.author	Chen, J
dc.contributor.author	Huen, MS
dc.date.accessioned	2011-07-27T01:25:49Z
dc.date.available	2011-07-27T01:25:49Z
dc.date.issued	2010
dc.description.abstract	The mammalian interphase chromatin responds to DNA damages by altering the compactness of its architecture, thereby permitting local access of DNA repair machineries. Adding to the cellular strategies of chromatin remodeling following DNA damage, our recent work identified the 53BP1-EXPAND1 module in promoting chromatin dynamics in response to DNA double-strand breaks. Endowed with a nucleosome-binding PWWP domain, EXPAND1 tethers to the chromatin where it is involved in maintaining basal chromatin accessibility in unperturbed cells. Interestingly, through its direct interaction with the DNA damage mediator protein 53BP1, EXPAND1 accumulates at the damage-modified chromatin and triggers its further decondensation. These observations, together with the fact that EXPAND 1 promotes cell survival following DNA damage, suggest that the chromatin-bound factor may facilitate DNA repair by regulating the organization of chromatin structure.
dc.description.nature	link_to_OA_fulltext
dc.identifier.citation	Nucleus (Austin, Tex.), 2010, v. 1 n. 6, p. 472-474 [How to Cite?] DOI: http://dx.doi.org/10.4161/nucl.1.6.13059
dc.identifier.doi	http://dx.doi.org/10.4161/nucl.1.6.13059
dc.identifier.epage	474
dc.identifier.hkuros	186733
dc.identifier.issn	1949-1042
dc.identifier.issue	6
dc.identifier.pmcid	PMC3027048
dc.identifier.pmid	21327088
dc.identifier.scopus	eid_2-s2.0-78549254849
dc.identifier.spage	472
dc.identifier.uri	http://hdl.handle.net/10722/135013
dc.identifier.volume	1
dc.language	eng
dc.publisher	Landes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/nucleus/
dc.publisher.place	United States
dc.relation.ispartof	Nucleus (Austin, Tex.)
dc.relation.references	References in Scopus
dc.subject.mesh	Chromatin - metabolism
dc.subject.mesh	Chromatin Assembly and Disassembly - genetics
dc.subject.mesh	Chromosomal Proteins, Non-Histone - metabolism
dc.subject.mesh	DNA Breaks, Double-Stranded
dc.subject.mesh	Intracellular Signaling Peptides and Proteins - metabolism
dc.subject	53Bp1
dc.subject	Chromatin
dc.subject	Expand1
dc.subject	Mum1
dc.title	The 53BP1-EXPAND1 connection in chromatin structure regulation.
dc.type	Article

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Author Affiliations

The University of Hong Kong
University of Texas M. D. Anderson Cancer Center