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Article: Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus)

TitleY-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus)
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 4 How to Cite?
AbstractBackground: The dorsal raphe nucleus (DRN) of the mesencephalon is a complex multi-functional and multi-transmitter nucleus involved in a wide range of behavioral and physiological processes. The DRN receives a direct input from the retina. However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells. Methodology/Principal Findings: The Mongolian gerbils are highly visual rodents with a diurnal/crepuscular activity rhythm. It has been widely used as experimental animals of various studies including seasonal affective disorders and depression. Young adult gerbils were used in the present study. DRN-projecting RGCs were identified following retrograde tracer injection into the DRN, characterized physiologically by extracellular recording and morphologically after intracellular filling. The result shows that DRN-projecting RGCs exhibit morphological characteristics typical of alpha RGCs and physiological response properties of Y-cells. Melanopsin was not detected in these RGCs and they show no evidence of intrinsic photosensitivity. Conclusions/Significance: These findings suggest that RGCs with alpha-like morphology and Y-like physiology appear to perform a non-imaging forming function and thus may participate in the modulation of DRN activity which includes regulation of sleep and mood. © 2011 Luan et al.
Persistent Identifierhttp://hdl.handle.net/10722/135001
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Science Foundation of China30831160516
Ministry of Science and Technology of China2011CB510206
2009CB320900
National Institutes of Health, USAR01 EY017809
NSFC/RGCN_HKU750/08
Fundamental Research Funds for the Central Universities21609101
National Basic Research Program of China (973 Program)2011CB707501
Funding Information:

This work was supported by National Science Foundation of China grants (30831160516 to M. Pu); Ministry of Science and Technology of China grants (2011CB510206 & 2009CB320900 to M. Pu); National Institutes of Health, USA grant R01 EY017809 (G. E. Pickard); NSFC/RGC Joint Research Scheme under the contract N_HKU750/08 (K-F. So), the Fundamental Research Funds for the Central Universities (21609101, KF So); National Basic Research Program of China (973 Program) (2011CB707501, K-F. So). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorLuan, Len_HK
dc.contributor.authorRen, Cen_HK
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorPickard, GEen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorPu, Men_HK
dc.date.accessioned2011-07-27T01:25:41Z-
dc.date.available2011-07-27T01:25:41Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 4en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135001-
dc.description.abstractBackground: The dorsal raphe nucleus (DRN) of the mesencephalon is a complex multi-functional and multi-transmitter nucleus involved in a wide range of behavioral and physiological processes. The DRN receives a direct input from the retina. However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells. Methodology/Principal Findings: The Mongolian gerbils are highly visual rodents with a diurnal/crepuscular activity rhythm. It has been widely used as experimental animals of various studies including seasonal affective disorders and depression. Young adult gerbils were used in the present study. DRN-projecting RGCs were identified following retrograde tracer injection into the DRN, characterized physiologically by extracellular recording and morphologically after intracellular filling. The result shows that DRN-projecting RGCs exhibit morphological characteristics typical of alpha RGCs and physiological response properties of Y-cells. Melanopsin was not detected in these RGCs and they show no evidence of intrinsic photosensitivity. Conclusions/Significance: These findings suggest that RGCs with alpha-like morphology and Y-like physiology appear to perform a non-imaging forming function and thus may participate in the modulation of DRN activity which includes regulation of sleep and mood. © 2011 Luan et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCell Shape - radiation effects-
dc.subject.meshIntracellular Space - metabolism - radiation effects-
dc.subject.meshRaphe Nuclei - cytology - physiology - radiation effects-
dc.subject.meshRetinal Ganglion Cells - cytology - radiation effects-
dc.subject.meshVisual Perception - radiation effects-
dc.titleY-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus)en_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0018938en_HK
dc.identifier.pmid21552551-
dc.identifier.pmcidPMC3084235-
dc.identifier.scopuseid_2-s2.0-79955705983en_HK
dc.identifier.hkuros186288en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955705983&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spagee18938en_US
dc.identifier.epagee18938en_US
dc.identifier.isiWOS:000290020700008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuan, L=26422366200en_HK
dc.identifier.scopusauthoridRen, C=38862708400en_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridYang, J=52064068000en_HK
dc.identifier.scopusauthoridPickard, GE=7003405442en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridPu, M=16073321400en_HK

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