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Article: Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: An animal study

TitleEffects of total glucosides of paeony for delaying onset of Sjogren's syndrome: An animal study
Authors
KeywordsSjogren's syndrome
Sialoadenitis
Total glucosides of paeony
Animal model
Issue Date2013
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
Journal of Cranio-Maxillofacial Surgery, 2013, v. 41 n. 7, p. 610-615 How to Cite?
AbstractObjective To investigate the effectiveness of total glucosides of paeony (TGP) on Sjogren's syndrome (SS) using non-obese diabetic (NOD) mice model. Study design Twenty-seven 8-week-old female NOD mice were assigned into TGP group, hydroxychloroquine (HCQ) group and normal saline (NS) group, receiving corresponding drugs respectively and sacrificed at 24-week-old. Saliva flow rate (SFR), ration of regulatory T cells, level of anti-SSA/SSB, histological changes in submandibular glands (SMG) and microarray analysis were assessed. The data were analyzed using SPSS. Results Compared to NS group, in TGP group, SFR, SMG index and the ration of regulatory T cells were significantly higher, while anti-SSA/SSB and lymphocytic foci were significantly lower. HCQ group demonstrated similar results except SMG index. Altered gene expression was found in 10.71% of TGP and 13.09% of HCQ of the profile. Conclusion TGP demonstrated a similar effectiveness as HCQ in delaying the onset of SS-like disease in NOD mice.
Persistent Identifierhttp://hdl.handle.net/10722/134998
ISSN
2015 Impact Factor: 1.592
2015 SCImago Journal Rankings: 1.010
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, CLen_US
dc.contributor.authorHe, Jen_US
dc.contributor.authorLi, ZGen_US
dc.contributor.authorZheng, LWen_US
dc.contributor.authorHua, Hen_US
dc.date.accessioned2011-07-27T01:25:32Z-
dc.date.available2011-07-27T01:25:32Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Cranio-Maxillofacial Surgery, 2013, v. 41 n. 7, p. 610-615en_US
dc.identifier.issn1010-5182-
dc.identifier.urihttp://hdl.handle.net/10722/134998-
dc.description.abstractObjective To investigate the effectiveness of total glucosides of paeony (TGP) on Sjogren's syndrome (SS) using non-obese diabetic (NOD) mice model. Study design Twenty-seven 8-week-old female NOD mice were assigned into TGP group, hydroxychloroquine (HCQ) group and normal saline (NS) group, receiving corresponding drugs respectively and sacrificed at 24-week-old. Saliva flow rate (SFR), ration of regulatory T cells, level of anti-SSA/SSB, histological changes in submandibular glands (SMG) and microarray analysis were assessed. The data were analyzed using SPSS. Results Compared to NS group, in TGP group, SFR, SMG index and the ration of regulatory T cells were significantly higher, while anti-SSA/SSB and lymphocytic foci were significantly lower. HCQ group demonstrated similar results except SMG index. Altered gene expression was found in 10.71% of TGP and 13.09% of HCQ of the profile. Conclusion TGP demonstrated a similar effectiveness as HCQ in delaying the onset of SS-like disease in NOD mice.-
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms-
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#-
dc.subjectSjogren's syndrome-
dc.subjectSialoadenitis-
dc.subjectTotal glucosides of paeony-
dc.subjectAnimal model-
dc.titleEffects of total glucosides of paeony for delaying onset of Sjogren's syndrome: An animal studyen_US
dc.typeArticleen_US
dc.identifier.emailZheng, LW: lwzheng@hku.hken_US
dc.identifier.authorityZheng, L=rp01411en_US
dc.identifier.doi10.1016/j.jcms.2012.11.042-
dc.identifier.pmid23333492-
dc.identifier.hkuros188919en_US
dc.identifier.hkuros232442-
dc.identifier.volume41-
dc.identifier.issue7-
dc.identifier.spage610-
dc.identifier.epage615-
dc.identifier.isiWOS:000325835000013-
dc.publisher.placeUnited Kingdom-

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