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Article: LMO2 promotes angiogenesis probably by up-regulation of bFGF in endothelial cells: An implication of its pathophysiological role in infantile haemangioma
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TitleLMO2 promotes angiogenesis probably by up-regulation of bFGF in endothelial cells: An implication of its pathophysiological role in infantile haemangioma
 
AuthorsSun, ZJ2 3
Cai, Y2 3
Chen, G2 3
Wang, R3
Jia, J2 3
Chen, XM2
Zheng, LW1
Zhao, YF2 3
 
KeywordsBFGF
Endothelial cells
Infantile haemangiomas
LMO2
 
Issue Date2010
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
 
CitationHistopathology, 2010, v. 57 n. 4, p. 622-632 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2559.2010.03676.x
 
AbstractAims: Infantile haemangiomas (IHs) are common benign vascular tumours distinctive for their perinatal presentation, rapid growth during the first year of life and subsequent slow involution. Recent research has indicated that endothelial cells of haemangiomas express LIM-only protein 2 (LMO2). The aim of this study was to investigate the role of LMO2 in the pathogenesis of IHs was investigated.Methods and results: Immunoreactivity of LMO2 was assessed in specimens of 19 IH. Stable transfection of LMO2 into human endothelial cell lines (EAhy926) was performed to evaluate the role of LMO2 in terms of the change in cell proliferation, cell cycle and cell migration as well as the expression level of angiogenic factors. Immunoreactivity for LMO2 was detected in all IH specimens, specifically in the nucleus of the endothelial cells. The intensity of LMO2 immunostaining decreased significantly from proliferative to involuting stages. Furthermore, the overexpression of LMO2 enhanced the proliferation and migration of the endothelial cells and promoted G0/G1-S-phase transition in vitro, together with an up-regulation of bFGF expression.Conclusions: LMO2 probably promotes angiogenesis by up-regulation of bFGF expression and thereby consequently influences progression of IH. © 2010 Blackwell Publishing Limited.
 
ISSN0309-0167
2012 Impact Factor: 2.857
2012 SCImago Journal Rankings: 1.134
 
DOIhttp://dx.doi.org/10.1111/j.1365-2559.2010.03676.x
 
ISI Accession Number IDWOS:000283078300015
Funding AgencyGrant Number
National Natural Science Foundation of China30600712
30872894
30973330
Funding Information:

This work was supported by grants from the National Natural Science Foundation of China (30600712) to Dr Z J Sun and (30872894 and 30973330) to Dr Y F Zhao. We thank Dr Roger A Zwahlen of The Faculty of Dentistry, The University of Hong Kong for his kind assistance in editing.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSun, ZJ
 
dc.contributor.authorCai, Y
 
dc.contributor.authorChen, G
 
dc.contributor.authorWang, R
 
dc.contributor.authorJia, J
 
dc.contributor.authorChen, XM
 
dc.contributor.authorZheng, LW
 
dc.contributor.authorZhao, YF
 
dc.date.accessioned2011-07-27T01:25:24Z
 
dc.date.available2011-07-27T01:25:24Z
 
dc.date.issued2010
 
dc.description.abstractAims: Infantile haemangiomas (IHs) are common benign vascular tumours distinctive for their perinatal presentation, rapid growth during the first year of life and subsequent slow involution. Recent research has indicated that endothelial cells of haemangiomas express LIM-only protein 2 (LMO2). The aim of this study was to investigate the role of LMO2 in the pathogenesis of IHs was investigated.Methods and results: Immunoreactivity of LMO2 was assessed in specimens of 19 IH. Stable transfection of LMO2 into human endothelial cell lines (EAhy926) was performed to evaluate the role of LMO2 in terms of the change in cell proliferation, cell cycle and cell migration as well as the expression level of angiogenic factors. Immunoreactivity for LMO2 was detected in all IH specimens, specifically in the nucleus of the endothelial cells. The intensity of LMO2 immunostaining decreased significantly from proliferative to involuting stages. Furthermore, the overexpression of LMO2 enhanced the proliferation and migration of the endothelial cells and promoted G0/G1-S-phase transition in vitro, together with an up-regulation of bFGF expression.Conclusions: LMO2 probably promotes angiogenesis by up-regulation of bFGF expression and thereby consequently influences progression of IH. © 2010 Blackwell Publishing Limited.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHistopathology, 2010, v. 57 n. 4, p. 622-632 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2559.2010.03676.x
 
dc.identifier.citeulike8049268
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2559.2010.03676.x
 
dc.identifier.epage632
 
dc.identifier.hkuros188022
 
dc.identifier.isiWOS:000283078300015
Funding AgencyGrant Number
National Natural Science Foundation of China30600712
30872894
30973330
Funding Information:

This work was supported by grants from the National Natural Science Foundation of China (30600712) to Dr Z J Sun and (30872894 and 30973330) to Dr Y F Zhao. We thank Dr Roger A Zwahlen of The Faculty of Dentistry, The University of Hong Kong for his kind assistance in editing.

 
dc.identifier.issn0309-0167
2012 Impact Factor: 2.857
2012 SCImago Journal Rankings: 1.134
 
dc.identifier.issue4
 
dc.identifier.pmid20955387
 
dc.identifier.scopuseid_2-s2.0-78650504772
 
dc.identifier.spage622
 
dc.identifier.urihttp://hdl.handle.net/10722/134986
 
dc.identifier.volume57
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHistopathology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshDNA-Binding Proteins - metabolism
 
dc.subject.meshEndothelial Cells - metabolism
 
dc.subject.meshFibroblast Growth Factor 2 - biosynthesis
 
dc.subject.meshHemangioma, Capillary - metabolism
 
dc.subject.meshMetalloproteins - metabolism
 
dc.subjectBFGF
 
dc.subjectEndothelial cells
 
dc.subjectInfantile haemangiomas
 
dc.subjectLMO2
 
dc.titleLMO2 promotes angiogenesis probably by up-regulation of bFGF in endothelial cells: An implication of its pathophysiological role in infantile haemangioma
 
dc.typeArticle
 
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<contributor.author>Jia, J</contributor.author>
<contributor.author>Chen, XM</contributor.author>
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<contributor.author>Zhao, YF</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University
  3. State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST)