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Article: Expression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
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TitleExpression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
 
AuthorsZhang, WB2
Zheng, LW2
Chua, DTT1
Cheung, LK2
 
Issue Date2011
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
 
CitationJournal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 11, p. 2860-2871 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2010.12.037
 
AbstractPurpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. © 2011 American Association of Oral and Maxillofacial Surgeons.
 
ISSN0278-2391
2013 Impact Factor: 1.280
 
DOIhttp://dx.doi.org/10.1016/j.joms.2010.12.037
 
ISI Accession Number IDWOS:000297138000033
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by a small project fund from the University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, WB
 
dc.contributor.authorZheng, LW
 
dc.contributor.authorChua, DTT
 
dc.contributor.authorCheung, LK
 
dc.date.accessioned2011-07-27T01:25:21Z
 
dc.date.available2011-07-27T01:25:21Z
 
dc.date.issued2011
 
dc.description.abstractPurpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. © 2011 American Association of Oral and Maxillofacial Surgeons.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 11, p. 2860-2871 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2010.12.037
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.joms.2010.12.037
 
dc.identifier.epage2871
 
dc.identifier.hkuros188020
 
dc.identifier.hkuros210168
 
dc.identifier.isiWOS:000297138000033
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by a small project fund from the University of Hong Kong.

 
dc.identifier.issn0278-2391
2013 Impact Factor: 1.280
 
dc.identifier.issue11
 
dc.identifier.pmid21741143
 
dc.identifier.scopuseid_2-s2.0-80054939289
 
dc.identifier.spage2860
 
dc.identifier.urihttp://hdl.handle.net/10722/134985
 
dc.identifier.volume69
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBone Morphogenetic Proteins - *analysis - radiation effects
 
dc.subject.meshFibroblast Growth Factor 2 - *analysis - radiation effects
 
dc.subject.meshMandible - *radiation effects - surgery
 
dc.subject.meshOsteogenesis, Distraction
 
dc.subject.meshVascular Endothelial Growth Factor A - analysis - radiation effects
 
dc.titleExpression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
 
dc.typeArticle
 
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<contributor.author>Zheng, LW</contributor.author>
<contributor.author>Chua, DTT</contributor.author>
<contributor.author>Cheung, LK</contributor.author>
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<description.abstract>Purpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. &#169; 2011 American Association of Oral and Maxillofacial Surgeons.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong