Article: Expression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis

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TitleExpression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
AuthorsZhang, WB2
Zheng, LW2
Chua, DTT1
Cheung, LK2
Issue Date2011
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
CitationJournal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 11, p. 2860-2871 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2010.12.037
AbstractPurpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. © 2011 American Association of Oral and Maxillofacial Surgeons.
ISSN0278-2391
2011 Impact Factor: 1.64
2011 SCImago Journal Rankings: 0.096
DOIhttp://dx.doi.org/10.1016/j.joms.2010.12.037
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhang, WB
dc.contributor.authorZheng, LW
dc.contributor.authorChua, DTT
dc.contributor.authorCheung, LK
dc.date.accessioned2011-07-27T01:25:21Z
dc.date.available2011-07-27T01:25:21Z
dc.date.issued2011
dc.description.abstractPurpose: The present study evaluated the expression of bone morphogenetic proteins (BMPs)-2, -4, -7, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in irradiated mandibles during distraction osteogenesis. Materials and Methods: A total of 24 rabbits were randomly assigned to the control and experimental groups. Each rabbit in the experimental group underwent preoperative radiation to 9 Gy in 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at day 7 (end of the latency period), day 12 (middle of active distraction), day 18 (end of active distraction), and day 25 (1 week after consolidation). The specimens were used for immunohistochemical staining and real-time polymerase chain reaction analysis. Results: Histologically, at day 25, cortical bone formation was much better in the control group than in the radiotherapy group. In the radiotherapy group, the bone spicules were aligned in the direction of tension stress. At day 12, the expression of BMP-2, -4, and -7 was elevated in the radiotherapy group compared with the control group. At day 25, the expression of BMP-2 was significantly greater in the radiotherapy group. At day 7, the expression of bFGF was significantly suppressed in the radiotherapy group. At day 12, the expression of bFGF and VEGF was significantly elevated in the radiotherapy group compared with the control group. At day 25, the expression of VEGF was significantly greater in the radiotherapy group. Conclusions: The results of our study have shown that radiotherapy changes the expression pattern of BMPs, VEGF, and bFGF. © 2011 American Association of Oral and Maxillofacial Surgeons.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 11, p. 2860-2871 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2010.12.037
dc.identifier.doihttp://dx.doi.org/10.1016/j.joms.2010.12.037
dc.identifier.epage2871
dc.identifier.hkuros188020
dc.identifier.hkuros210168
dc.identifier.isiWOS:000297138000033
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by a small project fund from the University of Hong Kong.

dc.identifier.issn0278-2391
2011 Impact Factor: 1.64
2011 SCImago Journal Rankings: 0.096
dc.identifier.issue11
dc.identifier.pmid21741143
dc.identifier.scopuseid_2-s2.0-80054939289
dc.identifier.spage2860
dc.identifier.urihttp://hdl.handle.net/10722/134985
dc.identifier.volume69
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
dc.relation.referencesReferences in Scopus
dc.subject.meshBone Morphogenetic Proteins - *analysis - radiation effects
dc.subject.meshFibroblast Growth Factor 2 - *analysis - radiation effects
dc.subject.meshMandible - *radiation effects - surgery
dc.subject.meshOsteogenesis, Distraction
dc.subject.meshVascular Endothelial Growth Factor A - analysis - radiation effects
dc.titleExpression of bone morphogenetic protein, vascular endothelial growth factor, and basic fibroblast growth factor in irradiated mandibles during distraction osteogenesis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong