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Article: Orthopaedic gene therapy using recombinant adeno-associated virus vectors

TitleOrthopaedic gene therapy using recombinant adeno-associated virus vectors
Authors
KeywordsBone
Cartilage
Gene therapy
Recombinant adeno-associated virus 2
Tendon
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 2011, v. 56 n. 7, p. 619-628 How to Cite?
AbstractUse of recombinant adeno-associated virus (rAAV) vectors is increasingly gaining popularity in gene therapy because of their desirable properties, including lack of pathogenicity, efficient transduction of dividing and non-dividing cells, and sustained maintenance of the viral genome. It is these features of rAAV vectors that made them the focus for gene-based therapy of skeletal tissue regeneration. This review outlines the biological characteristics of adeno-associated virus (AAV), states the biological processing as well as current advances of rAAV vectors, and describes the recent achievements of their applications in orthopaedic and craniofacial surgery. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/134980
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200711159013
Funding Information:

This study was supported by a grant from the seed-funding programme for basic research, the University of Hong Kong (project no. 200711159013).

References

 

DC FieldValueLanguage
dc.contributor.authorKe, Jen_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2011-07-27T01:25:18Z-
dc.date.available2011-07-27T01:25:18Z-
dc.date.issued2011en_HK
dc.identifier.citationArchives Of Oral Biology, 2011, v. 56 n. 7, p. 619-628en_HK
dc.identifier.issn0003-9969en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134980-
dc.description.abstractUse of recombinant adeno-associated virus (rAAV) vectors is increasingly gaining popularity in gene therapy because of their desirable properties, including lack of pathogenicity, efficient transduction of dividing and non-dividing cells, and sustained maintenance of the viral genome. It is these features of rAAV vectors that made them the focus for gene-based therapy of skeletal tissue regeneration. This review outlines the biological characteristics of adeno-associated virus (AAV), states the biological processing as well as current advances of rAAV vectors, and describes the recent achievements of their applications in orthopaedic and craniofacial surgery. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_HK
dc.relation.ispartofArchives of Oral Biologyen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#-
dc.subjectBoneen_HK
dc.subjectCartilageen_HK
dc.subjectGene therapyen_HK
dc.subjectRecombinant adeno-associated virus 2en_HK
dc.subjectTendonen_HK
dc.titleOrthopaedic gene therapy using recombinant adeno-associated virus vectorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9969&volume=56&issue=7&spage=619&epage=628&date=2011&atitle=Orthopaedic+gene+therapy+using+recombinant+adeno-associated+virus+vectors-
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.archoralbio.2010.12.010en_HK
dc.identifier.pmid21354554-
dc.identifier.scopuseid_2-s2.0-79959377435en_HK
dc.identifier.hkuros187873en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959377435&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume56en_HK
dc.identifier.issue7en_HK
dc.identifier.spage619en_HK
dc.identifier.epage628en_HK
dc.identifier.isiWOS:000293151500001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKe, J=8682099100en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridCheung, LK=36674702500en_HK
dc.identifier.citeulike8928006-

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