File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions

TitleCaveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions
Authors
Li, YLau, WMSo, KFTong, YShen, J
KeywordsAstrocyte
Caveolin-1
Hes1
Neural progenitor cells
Notch1
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2011, v. 407 n. 3, p. 517-524 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2011.03.050
AbstractIn the present study, we aim to elucidate the role of caveolin-1 in modulating astroglial differentiation of neural progenitor cells (NPCs) and the potential mechanisms involved. We first investigated astroglial differentiation and Notch signaling by detecting the expressions of S100β, GFAP, NICD and hairy enhancer of split 1 (Hes1) in the brains of wild-type and caveolin-1 knockout mice. Caveolin-1 knockout mice revealed remarkably less astroglial differentiation and lower levels of NICD and Hes1 expressions than wild type mice. We then studied the potential roles of caveolin-1 in modulating NICD and Hes1 expressions and astroglial differentiation in isolated cultured NPCs by using caveolin-1 peptide and caveolin-1 RNA silencing. In the differentiating NPCs, caveolin-1 peptide markedly promoted astroglial formation and up-regulated the expressions of NICD and Hes1. In contrast, the knockdown of caveolin-1 inhibited astroglial differentiation of NPCs and the expressions of NICD and Hes1. Taken together, these results provide strong evidence that caveolin-1 can promote astroglial differentiation of NPCs through modulating Notch1/NICD and Hes1 expressions. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/134772
ISSN
0006-291X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.770
ISI Accession Number ID
WOS:000289958500014
Funding AgencyGrant Number
Hong Kong RGC777610M
774808M
University of Hong Kong200807176043
Dr. Wong BL family donation
Funding Information:

We thank Dr. ShuPing Fu and Ms. XingMiao Chen for technical assistance of Caveolin-1 knockout Mice genotyping. This work was supported by Hong Kong RGC General Research Fund (GRF No. 777610M, No. 774808M, JGS), Small Project Funding of the University of Hong Kong (200807176043, JGS) and Dr. Wong BL family donation.

References
References in Scopus
Grants
Development of caveolin-1 as a target molecule for screening active compounds from herbal medicine in promoting neurogenesis for ischemic stroke

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorLau, WMen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorShen, Jen_HK
dc.date.accessioned2011-07-15T06:34:49Z-
dc.date.available2011-07-15T06:34:49Z-
dc.date.issued2011en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2011, v. 407 n. 3, p. 517-524en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/134772-
dc.description.abstractIn the present study, we aim to elucidate the role of caveolin-1 in modulating astroglial differentiation of neural progenitor cells (NPCs) and the potential mechanisms involved. We first investigated astroglial differentiation and Notch signaling by detecting the expressions of S100β, GFAP, NICD and hairy enhancer of split 1 (Hes1) in the brains of wild-type and caveolin-1 knockout mice. Caveolin-1 knockout mice revealed remarkably less astroglial differentiation and lower levels of NICD and Hes1 expressions than wild type mice. We then studied the potential roles of caveolin-1 in modulating NICD and Hes1 expressions and astroglial differentiation in isolated cultured NPCs by using caveolin-1 peptide and caveolin-1 RNA silencing. In the differentiating NPCs, caveolin-1 peptide markedly promoted astroglial formation and up-regulated the expressions of NICD and Hes1. In contrast, the knockdown of caveolin-1 inhibited astroglial differentiation of NPCs and the expressions of NICD and Hes1. Taken together, these results provide strong evidence that caveolin-1 can promote astroglial differentiation of NPCs through modulating Notch1/NICD and Hes1 expressions. © 2011 Elsevier Inc.en_HK
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectAstrocyteen_HK
dc.subjectCaveolin-1en_HK
dc.subjectHes1en_HK
dc.subjectNeural progenitor cellsen_HK
dc.subjectNotch1en_HK
dc.titleCaveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=407&spage=517&epage=524&date=2011&atitle=Caveolin-1+promote+astroglial+differentiation+of+neural+stem/progenitor+cells+through+modulating+Notch1/NICD+and+Hes1+expressions-
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2011.03.050en_HK
dc.identifier.pmid21414292en_HK
dc.identifier.scopuseid_2-s2.0-79954457415en_HK
dc.identifier.hkuros186209-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79954457415&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume407en_HK
dc.identifier.issue3en_HK
dc.identifier.spage517en_HK
dc.identifier.epage524en_HK
dc.identifier.isiWOS:000289958500014-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectDevelopment of caveolin-1 as a target molecule for screening active compounds from herbal medicine in promoting neurogenesis for ischemic stroke-
dc.identifier.scopusauthoridLi, Y=26643036800en_HK
dc.identifier.scopusauthoridLau, WM=16239172000en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK
dc.identifier.citeulike9010061-
dc.identifier.issnl0006-291X-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats