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Article: Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

TitleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
Authors
Issue Date1998
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 1998, v. 7 n. 5, p. 933-935 How to Cite?
Abstract
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
Persistent Identifierhttp://hdl.handle.net/10722/134760
ISSN
2013 Impact Factor: 6.677
ISI Accession Number ID
References

 

Author Affiliations
  1. Mount Sinai Medical Center Miami Beach
  2. Boston University School of Medicine
  3. Toronto General Hospital
  4. University of Toronto
DC FieldValueLanguage
dc.contributor.authorBrindle, Nen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorRogaeva, Een_HK
dc.contributor.authorPremkumar, Sen_HK
dc.contributor.authorLevesque, Gen_HK
dc.contributor.authorYu, Gen_HK
dc.contributor.authorIkeda, Men_HK
dc.contributor.authorNishimura, Men_HK
dc.contributor.authorPaterson, Aen_HK
dc.contributor.authorSorbi, Sen_HK
dc.contributor.authorDuara, Ren_HK
dc.contributor.authorFarrer, Len_HK
dc.contributor.authorSt GeorgeHyslop, Pen_HK
dc.date.accessioned2011-07-14T07:02:53Z-
dc.date.available2011-07-14T07:02:53Z-
dc.date.issued1998en_HK
dc.identifier.citationHuman Molecular Genetics, 1998, v. 7 n. 5, p. 933-935en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134760-
dc.description.abstractThe K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.en_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshAlzheimer Disease/enzymology/*geneticsen_US
dc.subject.meshApolipoprotein E4en_US
dc.subject.meshApolipoproteins E/geneticsen_US
dc.subject.meshButyrylcholinesterase/*geneticsen_US
dc.subject.meshChromosomes, Human, Pair 3/*geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailSong, Y: songy@hkucc.hku.hken_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/hmg/7.5.933en_HK
dc.identifier.pmid9536099en_HK
dc.identifier.scopuseid_2-s2.0-7144262433en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7144262433&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue5en_HK
dc.identifier.spage933en_HK
dc.identifier.epage935en_HK
dc.identifier.isiWOS:000073657000021-
dc.publisher.placeUnited Kingdomen_HK

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