File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
  • Basic View
  • Metadata View
  • XML View
TitleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
 
AuthorsBrindle, N4 3
Song, Y4 3
Rogaeva, E4 3
Premkumar, S2
Levesque, G4 3
Yu, G4 3
Ikeda, M4 3
Nishimura, M4 3
Paterson, A4
Sorbi, S
Duara, R1
Farrer, L2
St GeorgeHyslop, P4 3
 
Issue Date1998
 
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
CitationHuman Molecular Genetics, 1998, v. 7 n. 5, p. 933-935 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/7.5.933
 
AbstractThe K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
 
ISSN0964-6906
2013 Impact Factor: 6.677
 
DOIhttp://dx.doi.org/10.1093/hmg/7.5.933
 
ISI Accession Number IDWOS:000073657000021
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBrindle, N
 
dc.contributor.authorSong, Y
 
dc.contributor.authorRogaeva, E
 
dc.contributor.authorPremkumar, S
 
dc.contributor.authorLevesque, G
 
dc.contributor.authorYu, G
 
dc.contributor.authorIkeda, M
 
dc.contributor.authorNishimura, M
 
dc.contributor.authorPaterson, A
 
dc.contributor.authorSorbi, S
 
dc.contributor.authorDuara, R
 
dc.contributor.authorFarrer, L
 
dc.contributor.authorSt GeorgeHyslop, P
 
dc.date.accessioned2011-07-14T07:02:53Z
 
dc.date.available2011-07-14T07:02:53Z
 
dc.date.issued1998
 
dc.description.abstractThe K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHuman Molecular Genetics, 1998, v. 7 n. 5, p. 933-935 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/7.5.933
 
dc.identifier.doihttp://dx.doi.org/10.1093/hmg/7.5.933
 
dc.identifier.epage935
 
dc.identifier.isiWOS:000073657000021
 
dc.identifier.issn0964-6906
2013 Impact Factor: 6.677
 
dc.identifier.issue5
 
dc.identifier.pmid9536099
 
dc.identifier.scopuseid_2-s2.0-7144262433
 
dc.identifier.spage933
 
dc.identifier.urihttp://hdl.handle.net/10722/134760
 
dc.identifier.volume7
 
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHuman Molecular Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAlleles
 
dc.subject.meshAlzheimer Disease/enzymology/*genetics
 
dc.subject.meshApolipoprotein E4
 
dc.subject.meshApolipoproteins E/genetics
 
dc.subject.meshButyrylcholinesterase/*genetics
 
dc.subject.meshChromosomes, Human, Pair 3/*genetics
 
dc.subject.meshFemale
 
dc.subject.meshGene Frequency
 
dc.subject.meshGenetic Markers
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.titleAnalysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Brindle, N</contributor.author>
<contributor.author>Song, Y</contributor.author>
<contributor.author>Rogaeva, E</contributor.author>
<contributor.author>Premkumar, S</contributor.author>
<contributor.author>Levesque, G</contributor.author>
<contributor.author>Yu, G</contributor.author>
<contributor.author>Ikeda, M</contributor.author>
<contributor.author>Nishimura, M</contributor.author>
<contributor.author>Paterson, A</contributor.author>
<contributor.author>Sorbi, S</contributor.author>
<contributor.author>Duara, R</contributor.author>
<contributor.author>Farrer, L</contributor.author>
<contributor.author>St GeorgeHyslop, P</contributor.author>
<date.accessioned>2011-07-14T07:02:53Z</date.accessioned>
<date.available>2011-07-14T07:02:53Z</date.available>
<date.issued>1998</date.issued>
<identifier.citation>Human Molecular Genetics, 1998, v. 7 n. 5, p. 933-935</identifier.citation>
<identifier.issn>0964-6906</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/134760</identifier.uri>
<description.abstract>The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the &#949;4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.</description.abstract>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://hmg.oxfordjournals.org/</publisher>
<relation.ispartof>Human Molecular Genetics</relation.ispartof>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Alleles</subject.mesh>
<subject.mesh>Alzheimer Disease/enzymology/*genetics</subject.mesh>
<subject.mesh>Apolipoprotein E4</subject.mesh>
<subject.mesh>Apolipoproteins E/genetics</subject.mesh>
<subject.mesh>Butyrylcholinesterase/*genetics</subject.mesh>
<subject.mesh>Chromosomes, Human, Pair 3/*genetics</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Gene Frequency</subject.mesh>
<subject.mesh>Genetic Markers</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<title>Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1093/hmg/7.5.933</identifier.doi>
<identifier.pmid>9536099</identifier.pmid>
<identifier.scopus>eid_2-s2.0-7144262433</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-7144262433&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>7</identifier.volume>
<identifier.issue>5</identifier.issue>
<identifier.spage>933</identifier.spage>
<identifier.epage>935</identifier.epage>
<identifier.isi>WOS:000073657000021</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
</item>
Author Affiliations
  1. Mount Sinai Medical Center Miami Beach
  2. Boston University School of Medicine
  3. Toronto General Hospital
  4. University of Toronto