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Article: Association between angiotensin-converting enzyme and Alzheimer disease

TitleAssociation between angiotensin-converting enzyme and Alzheimer disease
Authors
Issue Date2000
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archneurol.com
Citation
Archives Of Neurology, 2000, v. 57 n. 2, p. 210-214 How to Cite?
AbstractBackground: Angiotensin-converting enzyme has been reported to show altered activity in patients with neurologic diseases. An insertion-deletion polymorphism in ACE has recently been linked to heart disease, cerebrovascular disease, and AD. Objective: To determine whether the angiotensin-converting enzyme (ACE) is associated with risk of Alzheimer disease (AD). Methods: We investigated the ACE polymorphism as a potential risk factor for AD in 151 patients with AD and 206 ethnically matched controls from Russia and in 236 patients with AD and 169 controls from North America by means of allele association methods and logistic regression. Results: None of the ACE genotypes was associated with increased susceptibility to AD in the total sample or in subsets stratified by apolipoprotein E gene (APOE) ε4 status. However, the D allele was more frequent among AD cases between ages 66 and 70 years compared with controls in both the Russian (P = .02) and North American (P = .001) datasets. In this age group, the effect of D (odds ratio, 11.2; 95% confidence interval, 2.9- 44.0) appeared to be independent of and equal or greater in magnitude to the effect of APOE ε4 (odds ratio, 7.8; 95% confidence interval, 3.5-7.4). Conclusions: Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.
Persistent Identifierhttp://hdl.handle.net/10722/134753
ISSN
2014 Impact Factor: 7.419
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFarrer, LAen_HK
dc.contributor.authorShcrbatich, Ten_HK
dc.contributor.authorKcryanov, SAen_HK
dc.contributor.authorKorovaitscva, GIen_HK
dc.contributor.authorRogaeva, EAen_HK
dc.contributor.authorPetruk, Sen_HK
dc.contributor.authorPremkumar, Sen_HK
dc.contributor.authorMoliaha, Yen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorPei, Yen_HK
dc.contributor.authorSato, Cen_HK
dc.contributor.authorSelczncva, NDen_HK
dc.contributor.authorVoshresenshaya, Sen_HK
dc.contributor.authorGolimbct, Ven_HK
dc.contributor.authorSorbi, Sen_HK
dc.contributor.authorDuara, Ren_HK
dc.contributor.authorGavrilova, Sen_HK
dc.contributor.authorSt GeorgcHyslop, PHen_HK
dc.contributor.authorRogaev, ELen_HK
dc.date.accessioned2011-07-14T07:02:43Z-
dc.date.available2011-07-14T07:02:43Z-
dc.date.issued2000en_HK
dc.identifier.citationArchives Of Neurology, 2000, v. 57 n. 2, p. 210-214en_HK
dc.identifier.issn0003-9942en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134753-
dc.description.abstractBackground: Angiotensin-converting enzyme has been reported to show altered activity in patients with neurologic diseases. An insertion-deletion polymorphism in ACE has recently been linked to heart disease, cerebrovascular disease, and AD. Objective: To determine whether the angiotensin-converting enzyme (ACE) is associated with risk of Alzheimer disease (AD). Methods: We investigated the ACE polymorphism as a potential risk factor for AD in 151 patients with AD and 206 ethnically matched controls from Russia and in 236 patients with AD and 169 controls from North America by means of allele association methods and logistic regression. Results: None of the ACE genotypes was associated with increased susceptibility to AD in the total sample or in subsets stratified by apolipoprotein E gene (APOE) ε4 status. However, the D allele was more frequent among AD cases between ages 66 and 70 years compared with controls in both the Russian (P = .02) and North American (P = .001) datasets. In this age group, the effect of D (odds ratio, 11.2; 95% confidence interval, 2.9- 44.0) appeared to be independent of and equal or greater in magnitude to the effect of APOE ε4 (odds ratio, 7.8; 95% confidence interval, 3.5-7.4). Conclusions: Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.en_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archneurol.comen_HK
dc.relation.ispartofArchives of Neurologyen_HK
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshAlzheimer Disease/*enzymology/epidemiology/geneticsen_US
dc.subject.meshApolipoproteins E/genetics/metabolismen_US
dc.subject.meshDNA/analysis/geneticsen_US
dc.subject.meshDNA Primersen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMoscow/epidemiologyen_US
dc.subject.meshOntario/epidemiologyen_US
dc.subject.meshPeptidyl-Dipeptidase A/genetics/*metabolismen_US
dc.subject.meshRisk Factorsen_US
dc.titleAssociation between angiotensin-converting enzyme and Alzheimer diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10681079-
dc.identifier.scopuseid_2-s2.0-12944310975en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12944310975&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue2en_HK
dc.identifier.spage210en_HK
dc.identifier.epage214en_HK
dc.identifier.isiWOS:000085208700007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFarrer, LA=7005139839en_HK
dc.identifier.scopusauthoridShcrbatich, T=36827118700en_HK
dc.identifier.scopusauthoridKcryanov, SA=36826211900en_HK
dc.identifier.scopusauthoridKorovaitscva, GI=36826068700en_HK
dc.identifier.scopusauthoridRogaeva, EA=35372614800en_HK
dc.identifier.scopusauthoridPetruk, S=6603618780en_HK
dc.identifier.scopusauthoridPremkumar, S=6603080131en_HK
dc.identifier.scopusauthoridMoliaha, Y=36826575400en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridPei, Y=36826735400en_HK
dc.identifier.scopusauthoridSato, C=7201887342en_HK
dc.identifier.scopusauthoridSelczncva, ND=36827009400en_HK
dc.identifier.scopusauthoridVoshresenshaya, S=36827506300en_HK
dc.identifier.scopusauthoridGolimbct, V=36825918000en_HK
dc.identifier.scopusauthoridSorbi, S=7004417453en_HK
dc.identifier.scopusauthoridDuara, R=7005297173en_HK
dc.identifier.scopusauthoridGavrilova, S=7004829216en_HK
dc.identifier.scopusauthoridSt GeorgcHyslop, PH=36826930000en_HK
dc.identifier.scopusauthoridRogaev, EL=35391858800en_HK

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