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Article: Association between bleomycin hydrolase and Alzheimer's disease in Caucasians

TitleAssociation between bleomycin hydrolase and Alzheimer's disease in Caucasians
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
Citation
Annals Of Neurology, 1998, v. 44 n. 5, p. 808-811 How to Cite?
AbstractA recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.
Persistent Identifierhttp://hdl.handle.net/10722/134750
ISSN
2015 Impact Factor: 9.638
2015 SCImago Journal Rankings: 5.584
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFarrer, LAen_HK
dc.contributor.authorAbraham, CRen_HK
dc.contributor.authorHaines, JLen_HK
dc.contributor.authorRogaeva, EAen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorMcGraw, WTen_HK
dc.contributor.authorBrindle, Nen_HK
dc.contributor.authorPremkumar, Sen_HK
dc.contributor.authorScott, WKen_HK
dc.contributor.authorYamaoka, LHen_HK
dc.contributor.authorSaunders, AMen_HK
dc.contributor.authorRoses, ADen_HK
dc.contributor.authorAuerbach, SAen_HK
dc.contributor.authorSorbi, Sen_HK
dc.contributor.authorDuara, Ren_HK
dc.contributor.authorPericakVance, MAen_HK
dc.contributor.authorSt GeorgeHyslop, PHen_HK
dc.date.accessioned2011-07-14T07:02:39Z-
dc.date.available2011-07-14T07:02:39Z-
dc.date.issued1998en_HK
dc.identifier.citationAnnals Of Neurology, 1998, v. 44 n. 5, p. 808-811en_HK
dc.identifier.issn0364-5134en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134750-
dc.description.abstractA recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.en_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645en_HK
dc.relation.ispartofAnnals of Neurologyen_HK
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshAlzheimer Disease/*geneticsen_US
dc.subject.meshApolipoproteins E/geneticsen_US
dc.subject.meshBostonen_US
dc.subject.meshCysteine Endopeptidases/*geneticsen_US
dc.subject.meshEuropean Continental Ancestry Group/*geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNorth Carolinaen_US
dc.subject.mesh*Polymorphism, Geneticen_US
dc.subject.meshReference Valuesen_US
dc.titleAssociation between bleomycin hydrolase and Alzheimer's disease in Caucasiansen_HK
dc.typeArticleen_HK
dc.identifier.emailSong, Y:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ana.410440515en_US
dc.identifier.pmid9818937-
dc.identifier.scopuseid_2-s2.0-0031738821en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031738821&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue5en_HK
dc.identifier.spage808en_HK
dc.identifier.epage811en_HK
dc.identifier.isiWOS:000076880800014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFarrer, LA=7005139839en_HK
dc.identifier.scopusauthoridAbraham, CR=35730736900en_HK
dc.identifier.scopusauthoridHaines, JL=35371857000en_HK
dc.identifier.scopusauthoridRogaeva, EA=35372614800en_HK
dc.identifier.scopusauthoridSong, Y=7404921212en_HK
dc.identifier.scopusauthoridMcGraw, WT=7004189438en_HK
dc.identifier.scopusauthoridBrindle, N=7004637236en_HK
dc.identifier.scopusauthoridPremkumar, S=6603080131en_HK
dc.identifier.scopusauthoridScott, WK=7403054141en_HK
dc.identifier.scopusauthoridYamaoka, LH=35392408700en_HK
dc.identifier.scopusauthoridSaunders, AM=7201876814en_HK
dc.identifier.scopusauthoridRoses, AD=35352401800en_HK
dc.identifier.scopusauthoridAuerbach, SA=36922690200en_HK
dc.identifier.scopusauthoridSorbi, S=7004417453en_HK
dc.identifier.scopusauthoridDuara, R=7005297173en_HK
dc.identifier.scopusauthoridPericakVance, MA=7102304343en_HK
dc.identifier.scopusauthoridSt GeorgeHyslop, PH=7005637468en_HK

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