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Article: Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE
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TitleAbsence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE
 
AuthorsSong, YQ6 5
Rogaeva, E6 5
Premkumar, S4
Brindle, N6 5
Kawarai, T6 5
Orlacchio, A6 5
Yu, G6 5
Levesque, G6 5
Nishimura, M6 5
Ikeda, M6 5
Pei, Y6 5
O'Toole, C6 5
Duara, R1
Barker, W1
Sorbi, S3
Freedman, M2
Farrer, L4
St GeorgeHyslop, P6 5
 
Keywords-491 A/T polymorphism
Alzheimer disease
APOE ε2/ε3/ε4 polymorphism
 
Issue Date1998
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
 
CitationNeuroscience Letters, 1998, v. 250 n. 3, p. 189-192 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3940(98)00470-4
 
AbstractA novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.
 
ISSN0304-3940
2012 Impact Factor: 2.026
2012 SCImago Journal Rankings: 0.815
 
DOIhttp://dx.doi.org/10.1016/S0304-3940(98)00470-4
 
ISI Accession Number IDWOS:000075092500013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSong, YQ
 
dc.contributor.authorRogaeva, E
 
dc.contributor.authorPremkumar, S
 
dc.contributor.authorBrindle, N
 
dc.contributor.authorKawarai, T
 
dc.contributor.authorOrlacchio, A
 
dc.contributor.authorYu, G
 
dc.contributor.authorLevesque, G
 
dc.contributor.authorNishimura, M
 
dc.contributor.authorIkeda, M
 
dc.contributor.authorPei, Y
 
dc.contributor.authorO'Toole, C
 
dc.contributor.authorDuara, R
 
dc.contributor.authorBarker, W
 
dc.contributor.authorSorbi, S
 
dc.contributor.authorFreedman, M
 
dc.contributor.authorFarrer, L
 
dc.contributor.authorSt GeorgeHyslop, P
 
dc.date.accessioned2011-07-14T07:01:46Z
 
dc.date.available2011-07-14T07:01:46Z
 
dc.date.issued1998
 
dc.description.abstractA novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeuroscience Letters, 1998, v. 250 n. 3, p. 189-192 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3940(98)00470-4
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0304-3940(98)00470-4
 
dc.identifier.epage192
 
dc.identifier.isiWOS:000075092500013
 
dc.identifier.issn0304-3940
2012 Impact Factor: 2.026
2012 SCImago Journal Rankings: 0.815
 
dc.identifier.issue3
 
dc.identifier.pmid9708864
 
dc.identifier.scopuseid_2-s2.0-0032503943
 
dc.identifier.spage189
 
dc.identifier.urihttp://hdl.handle.net/10722/134744
 
dc.identifier.volume250
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
 
dc.publisher.placeIreland
 
dc.relation.ispartofNeuroscience Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAlzheimer Disease/*genetics
 
dc.subject.meshApolipoproteins E/*genetics
 
dc.subject.meshGene Frequency
 
dc.subject.meshHumans
 
dc.subject.meshPolymorphism, Genetic/*genetics
 
dc.subject.meshRegulatory Sequences, Nucleic Acid/*genetics
 
dc.subject-491 A/T polymorphism
 
dc.subjectAlzheimer disease
 
dc.subjectAPOE ε2/ε3/ε4 polymorphism
 
dc.titleAbsence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE
 
dc.typeArticle
 
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Author Affiliations
  1. Wien Ctr.
  2. Baycrest
  3. Università degli Studi di Firenze
  4. Boston University School of Medicine
  5. Toronto General Hospital
  6. University of Toronto