Article: Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE

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TitleAbsence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE
AuthorsSong, YQ5 6
Rogaeva, E5 6
Premkumar, S4
Brindle, N5 6
Kawarai, T5 6
Orlacchio, A5 6
Yu, G5 6
Levesque, G5 6
Nishimura, M5 6
Ikeda, M5 6
Pei, Y5 6
O'Toole, C5 6
Duara, R1
Barker, W1
Sorbi, S3
Freedman, M2
Farrer, L4
St GeorgeHyslop, P5 6
Keywords-491 A/T polymorphism
Alzheimer disease
APOE ε2/ε3/ε4 polymorphism
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
CitationNeuroscience Letters, 1998, v. 250 n. 3, p. 189-192 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3940(98)00470-4
AbstractA novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.
ISSN0304-3940
2011 Impact Factor: 2.105
2011 SCImago Journal Rankings: 0.163
DOIhttp://dx.doi.org/10.1016/S0304-3940(98)00470-4
ISI Accession Number IDWOS:000075092500013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSong, YQ
dc.contributor.authorRogaeva, E
dc.contributor.authorPremkumar, S
dc.contributor.authorBrindle, N
dc.contributor.authorKawarai, T
dc.contributor.authorOrlacchio, A
dc.contributor.authorYu, G
dc.contributor.authorLevesque, G
dc.contributor.authorNishimura, M
dc.contributor.authorIkeda, M
dc.contributor.authorPei, Y
dc.contributor.authorO'Toole, C
dc.contributor.authorDuara, R
dc.contributor.authorBarker, W
dc.contributor.authorSorbi, S
dc.contributor.authorFreedman, M
dc.contributor.authorFarrer, L
dc.contributor.authorSt GeorgeHyslop, P
dc.date.accessioned2011-07-14T07:01:46Z
dc.date.available2011-07-14T07:01:46Z
dc.date.issued1998
dc.description.abstractA novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeuroscience Letters, 1998, v. 250 n. 3, p. 189-192 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3940(98)00470-4
dc.identifier.doihttp://dx.doi.org/10.1016/S0304-3940(98)00470-4
dc.identifier.epage192
dc.identifier.isiWOS:000075092500013
dc.identifier.issn0304-3940
2011 Impact Factor: 2.105
2011 SCImago Journal Rankings: 0.163
dc.identifier.issue3
dc.identifier.pmid9708864
dc.identifier.scopuseid_2-s2.0-0032503943
dc.identifier.spage189
dc.identifier.urihttp://hdl.handle.net/10722/134744
dc.identifier.volume250
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
dc.publisher.placeIreland
dc.relation.ispartofNeuroscience Letters
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAlzheimer Disease/*genetics
dc.subject.meshApolipoproteins E/*genetics
dc.subject.meshGene Frequency
dc.subject.meshHumans
dc.subject.meshPolymorphism, Genetic/*genetics
dc.subject.meshRegulatory Sequences, Nucleic Acid/*genetics
dc.subject-491 A/T polymorphism
dc.subjectAlzheimer disease
dc.subjectAPOE ε2/ε3/ε4 polymorphism
dc.titleAbsence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE
dc.typeArticle
Author Affiliations
  1. Wien Ctr.
  2. Baycrest
  3. Università degli Studi di Firenze
  4. Boston University School of Medicine
  5. Toronto General Hospital
  6. University of Toronto