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Article: Influenza surveillance and excess associated mortality in Guangzhou, China
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TitleInfluenza surveillance and excess associated mortality in Guangzhou, China
 
AuthorsOu, CQ
He, JF
Deng, AP
Yang, L
Chan, KP
Chen, PY
Wong, CM
 
Issue Date2011
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.com
 
CitationEpidemiology, 2011, v. 22, suppl. 1, p. S153 [How to Cite?]
DOI: http://dx.doi.org/10.1097/01.ede.0000392141.28009.8d
 
AbstractBackground/Aims: Although surveillance for influenza-like illness (ILI) is widely accepted as syndromic surveillance of influenza, the question remains whether ILI surveillance can serve as an early warning of influenza activity. There is a great deal of evidence that influenza is associated with considerable morbidity and mortality. However, few studies of disease burden of influenza are from outside developed countries. This study aimed to describe surveillance of influenza and assess mortality impact of influenza in Guangzhou, China. Methods: Guangdong Center of Disease Control and Prevention (CDC) provided data of weekly number of ILI and influenza virology data for the 3-year period of 2004–2006 in Guangzhou, China. The influenza data was matched with weekly counts of mortality and meteorological measures. Cross-correlation was performed to examine the time lag between weekly number of cases with ILI and positive rate of influenza isolation, after filtering the trend and seasonality of each time-series and controlling for meteorological effects. Poisson regression was used to model weekly counts of mortality on influenza activity after adjustment for potential confounding. Results: Influenza was circulated through the whole year during the period 2004–2006 in Influenza was circulated through the whole year during the period 2004–2006 in Guangzhou, China. Variation of weekly number of ILI cases preceded the positive rate of influenza isolates by 3 weeks. The excess mortality associated with influenza was 2.8% and 6.6% for cardiovascular diseases and respiratory diseases, respectively. Correspondingly, the influence-associated deaths per 1000 population were 6.4 and 7.3, respectively. The estimates of ILI-associated mortality were triple or fourfold. Conclusion: Compared with laboratory-based virology surveillance, clinical surveillance of ILI from sentinel hospitals offers earlier warning of increased incidence of influenza in population. Influenza poses a substantial burden on mortality in Guangzhou, China, where the virology surveillance of influenza should be strengthened.
 
DescriptionAbstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Health Impact Assessment and Burden of Disease (PP-31-141)
 
ISSN1044-3983
2012 Impact Factor: 5.738
2012 SCImago Journal Rankings: 2.155
 
DOIhttp://dx.doi.org/10.1097/01.ede.0000392141.28009.8d
 
ISI Accession Number IDWOS:000285400800449
 
DC FieldValue
dc.contributor.authorOu, CQ
 
dc.contributor.authorHe, JF
 
dc.contributor.authorDeng, AP
 
dc.contributor.authorYang, L
 
dc.contributor.authorChan, KP
 
dc.contributor.authorChen, PY
 
dc.contributor.authorWong, CM
 
dc.date.accessioned2011-07-14T06:37:28Z
 
dc.date.available2011-07-14T06:37:28Z
 
dc.date.issued2011
 
dc.description.abstractBackground/Aims: Although surveillance for influenza-like illness (ILI) is widely accepted as syndromic surveillance of influenza, the question remains whether ILI surveillance can serve as an early warning of influenza activity. There is a great deal of evidence that influenza is associated with considerable morbidity and mortality. However, few studies of disease burden of influenza are from outside developed countries. This study aimed to describe surveillance of influenza and assess mortality impact of influenza in Guangzhou, China. Methods: Guangdong Center of Disease Control and Prevention (CDC) provided data of weekly number of ILI and influenza virology data for the 3-year period of 2004–2006 in Guangzhou, China. The influenza data was matched with weekly counts of mortality and meteorological measures. Cross-correlation was performed to examine the time lag between weekly number of cases with ILI and positive rate of influenza isolation, after filtering the trend and seasonality of each time-series and controlling for meteorological effects. Poisson regression was used to model weekly counts of mortality on influenza activity after adjustment for potential confounding. Results: Influenza was circulated through the whole year during the period 2004–2006 in Influenza was circulated through the whole year during the period 2004–2006 in Guangzhou, China. Variation of weekly number of ILI cases preceded the positive rate of influenza isolates by 3 weeks. The excess mortality associated with influenza was 2.8% and 6.6% for cardiovascular diseases and respiratory diseases, respectively. Correspondingly, the influence-associated deaths per 1000 population were 6.4 and 7.3, respectively. The estimates of ILI-associated mortality were triple or fourfold. Conclusion: Compared with laboratory-based virology surveillance, clinical surveillance of ILI from sentinel hospitals offers earlier warning of increased incidence of influenza in population. Influenza poses a substantial burden on mortality in Guangzhou, China, where the virology surveillance of influenza should be strengthened.
 
dc.descriptionAbstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August–1 September 2010: Health Impact Assessment and Burden of Disease (PP-31-141)
 
dc.identifier.citationEpidemiology, 2011, v. 22, suppl. 1, p. S153 [How to Cite?]
DOI: http://dx.doi.org/10.1097/01.ede.0000392141.28009.8d
 
dc.identifier.doihttp://dx.doi.org/10.1097/01.ede.0000392141.28009.8d
 
dc.identifier.epageS153
 
dc.identifier.hkuros186194
 
dc.identifier.isiWOS:000285400800449
 
dc.identifier.issn1044-3983
2012 Impact Factor: 5.738
2012 SCImago Journal Rankings: 2.155
 
dc.identifier.openurl
 
dc.identifier.spageS153
 
dc.identifier.urihttp://hdl.handle.net/10722/134743
 
dc.identifier.volume22, suppl. 1
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.com
 
dc.relation.ispartofEpidemiology
 
dc.titleInfluenza surveillance and excess associated mortality in Guangzhou, China
 
dc.typeArticle
 
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<item><contributor.author>Ou, CQ</contributor.author>
<contributor.author>He, JF</contributor.author>
<contributor.author>Deng, AP</contributor.author>
<contributor.author>Yang, L</contributor.author>
<contributor.author>Chan, KP</contributor.author>
<contributor.author>Chen, PY</contributor.author>
<contributor.author>Wong, CM</contributor.author>
<date.accessioned>2011-07-14T06:37:28Z</date.accessioned>
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<description>Abstracts: ISEE 22nd Annual Conference, Seoul, Korea, 28 August&#8211;1 September 2010: Health Impact Assessment and Burden of Disease (PP-31-141)</description>
<description.abstract>Background/Aims:   
Although surveillance for influenza-like illness (ILI) is widely accepted as syndromic surveillance of influenza, the question remains whether ILI surveillance can serve as an early warning of influenza activity. There is a great deal of evidence that influenza is associated with considerable morbidity and mortality. However, few studies of disease burden of influenza are from outside developed countries. This study aimed to describe surveillance of influenza and assess mortality impact of influenza in Guangzhou, China.
   
Methods:   
Guangdong Center of Disease Control and Prevention (CDC) provided data of weekly number of ILI and influenza virology data for the 3-year period of 2004&#8211;2006 in Guangzhou, China. The influenza data was matched with weekly counts of mortality and meteorological measures. Cross-correlation was performed to examine the time lag between weekly number of cases with ILI and positive rate of influenza isolation, after filtering the trend and seasonality of each time-series and controlling for meteorological effects. Poisson regression was used to model weekly counts of mortality on influenza activity after adjustment for potential confounding.
   
Results:   
Influenza was circulated through the whole year during the period 2004&#8211;2006 in Influenza was circulated through the whole year during the period 2004&#8211;2006 in Guangzhou, China. Variation of weekly number of ILI cases preceded the positive rate of influenza isolates by 3 weeks. The excess mortality associated with influenza was 2.8% and 6.6% for cardiovascular diseases and respiratory diseases, respectively. Correspondingly, the influence-associated deaths per 1000 population were 6.4 and 7.3, respectively. The estimates of ILI-associated mortality were triple or fourfold.
   
Conclusion:   
Compared with laboratory-based virology surveillance, clinical surveillance of ILI from sentinel hospitals offers earlier warning of increased incidence of influenza in population. Influenza poses a substantial burden on mortality in Guangzhou, China, where the virology surveillance of influenza should be strengthened.</description.abstract>
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