Article: A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy

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TitleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
AuthorsChai, J1
Hon, E1
Li, CF1
Pun, TC1
Yeung, SB1
Ho, PC1
KeywordsBlood loss
Hysterectomy
Misoprostol
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
CitationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejogrb.2011.03.023
AbstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.
ISSN0301-2115
2011 Impact Factor: 1.974
2011 SCImago Journal Rankings: 0.141
DOIhttp://dx.doi.org/10.1016/j.ejogrb.2011.03.023
ISI Accession Number IDWOS:000295071600015
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChai, J
dc.contributor.authorHon, E
dc.contributor.authorLi, CF
dc.contributor.authorPun, TC
dc.contributor.authorYeung, SB
dc.contributor.authorHo, PC
dc.date.accessioned2011-07-08T07:29:37Z
dc.date.available2011-07-08T07:29:37Z
dc.date.issued2011
dc.description.abstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejogrb.2011.03.023
dc.identifier.citeulike9229699
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejogrb.2011.03.023
dc.identifier.epage75
dc.identifier.hkuros185991
dc.identifier.hkuros202251
dc.identifier.isiWOS:000295071600015
dc.identifier.issn0301-2115
2011 Impact Factor: 1.974
2011 SCImago Journal Rankings: 0.141
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid21514988
dc.identifier.scopuseid_2-s2.0-80051901341
dc.identifier.spage72
dc.identifier.urihttp://hdl.handle.net/10722/134715
dc.identifier.volume158
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
dc.publisher.placeIreland
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.relation.referencesReferences in Scopus
dc.subjectBlood loss
dc.subjectHysterectomy
dc.subjectMisoprostol
dc.titleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong