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Article: A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy

TitleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
Authors
KeywordsBlood loss
Hysterectomy
Misoprostol
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
Citation
European Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75 How to Cite?
AbstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/134715
ISSN
2014 Impact Factor: 1.695
2014 SCImago Journal Rankings: 0.738
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChai, Jen_HK
dc.contributor.authorHon, Een_HK
dc.contributor.authorLi, CFen_HK
dc.contributor.authorPun, TCen_HK
dc.contributor.authorYeung, SBen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2011-07-08T07:29:37Z-
dc.date.available2011-07-08T07:29:37Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75en_HK
dc.identifier.issn0301-2115en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134715-
dc.description.abstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.en_HK
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrben_HK
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biologyen_HK
dc.subjectBlood lossen_HK
dc.subjectHysterectomyen_HK
dc.subjectMisoprostolen_HK
dc.titleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-2115&volume=158&issue=1&spage=72&epage=75&date=2011&atitle=A+pilot+study+of+pre-operative+misoprostol+in+reducing+operative+blood+loss+during+hysterectomy-
dc.identifier.emailChai, J:jchai@hkucc.hku.hken_HK
dc.identifier.emailYeung, SB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityChai, J=rp00241en_HK
dc.identifier.authorityYeung, SB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejogrb.2011.03.023en_HK
dc.identifier.pmid21514988en_HK
dc.identifier.scopuseid_2-s2.0-80051901341en_HK
dc.identifier.hkuros185991-
dc.identifier.hkuros202251-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051901341&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume158en_HK
dc.identifier.issue1en_HK
dc.identifier.spage72en_HK
dc.identifier.epage75en_HK
dc.identifier.isiWOS:000295071600015-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChai, J=35200414100en_HK
dc.identifier.scopusauthoridHon, E=7005164611en_HK
dc.identifier.scopusauthoridLi, CF=14830505800en_HK
dc.identifier.scopusauthoridPun, TC=7005509306en_HK
dc.identifier.scopusauthoridYeung, SB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.citeulike9229699-

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