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Article: A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
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TitleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
 
AuthorsChai, J1
Hon, E1
Li, CF1
Pun, TC1
Yeung, SB1
Ho, PC1
 
KeywordsBlood loss
Hysterectomy
Misoprostol
 
Issue Date2011
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
 
CitationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejogrb.2011.03.023
 
AbstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.
 
ISSN0301-2115
2013 Impact Factor: 1.627
2013 SCImago Journal Rankings: 0.843
 
DOIhttp://dx.doi.org/10.1016/j.ejogrb.2011.03.023
 
ISI Accession Number IDWOS:000295071600015
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChai, J
 
dc.contributor.authorHon, E
 
dc.contributor.authorLi, CF
 
dc.contributor.authorPun, TC
 
dc.contributor.authorYeung, SB
 
dc.contributor.authorHo, PC
 
dc.date.accessioned2011-07-08T07:29:37Z
 
dc.date.available2011-07-08T07:29:37Z
 
dc.date.issued2011
 
dc.description.abstractObjective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. © 2011 Elsevier Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 2011, v. 158 n. 1, p. 72-75 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejogrb.2011.03.023
 
dc.identifier.citeulike9229699
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejogrb.2011.03.023
 
dc.identifier.epage75
 
dc.identifier.hkuros185991
 
dc.identifier.hkuros202251
 
dc.identifier.isiWOS:000295071600015
 
dc.identifier.issn0301-2115
2013 Impact Factor: 1.627
2013 SCImago Journal Rankings: 0.843
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid21514988
 
dc.identifier.scopuseid_2-s2.0-80051901341
 
dc.identifier.spage72
 
dc.identifier.urihttp://hdl.handle.net/10722/134715
 
dc.identifier.volume158
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
 
dc.publisher.placeIreland
 
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBlood loss
 
dc.subjectHysterectomy
 
dc.subjectMisoprostol
 
dc.titleA pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy
 
dc.typeArticle
 
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<contributor.author>Yeung, SB</contributor.author>
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<description.abstract>Objective: To investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas. Study design: A cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n = 32) or placebo containing 20 mg vitamin B 6 (n = 32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects. Results: Women who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 &#177; 361.3 ml versus 521.4 &#177; 297.4 ml, for misoprostol and placebo group respectively; P = 0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P = 0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups. Conclusion: A single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas. &#169; 2011 Elsevier Ireland Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong