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Article: Urocortin and cardiovascular protection

TitleUrocortin and cardiovascular protection
Authors
Huang, YYao, XQLau, CWChan, YCTsang, SYChan, FL
KeywordsChemicals And Cas Registry Numbers
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2004, v. 25 n. 3, p. 257-265 How to Cite?
AbstractUrocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.
Persistent Identifierhttp://hdl.handle.net/10722/134685
ISSN
1671-4083
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.882
ISI Accession Number ID
WOS:000220117800001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorYao, XQen_HK
dc.contributor.authorLau, CWen_HK
dc.contributor.authorChan, YCen_HK
dc.contributor.authorTsang, SYen_HK
dc.contributor.authorChan, FLen_HK
dc.date.accessioned2011-07-05T08:24:21Z-
dc.date.available2011-07-05T08:24:21Z-
dc.date.issued2004en_HK
dc.identifier.citationActa Pharmacologica Sinica, 2004, v. 25 n. 3, p. 257-265en_HK
dc.identifier.issn1671-4083en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134685-
dc.description.abstractUrocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.htmlen_HK
dc.relation.ispartofActa Pharmacologica Sinicaen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshCardiotonic Agents - pharmacologyen_HK
dc.subject.meshCorticotropin-Releasing Hormone - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshReceptors, Corticotropin-Releasing Hormone - drug effectsen_HK
dc.subject.meshUrocortinsen_HK
dc.subject.meshVasodilator Agents - pharmacologyen_HK
dc.titleUrocortin and cardiovascular protectionen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YC:yauchi@graduate.hku.hken_HK
dc.identifier.authorityChan, YC=rp01502en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15000874-
dc.identifier.scopuseid_2-s2.0-1542314291en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542314291&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue3en_HK
dc.identifier.spage257en_HK
dc.identifier.epage265en_HK
dc.identifier.isiWOS:000220117800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, Y=7501573013en_HK
dc.identifier.scopusauthoridYao, XQ=7402529434en_HK
dc.identifier.scopusauthoridLau, CW=7401968520en_HK
dc.identifier.scopusauthoridChan, YC=7403676116en_HK
dc.identifier.scopusauthoridTsang, SY=7102255908en_HK
dc.identifier.scopusauthoridChan, FL=15050111400en_HK
dc.identifier.issnl1671-4083-

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