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Article: Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase

TitleGold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase
Authors
Issue Date2010
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2010, v. 46 n. 41, p. 7691-7693 How to Cite?
AbstractCoinage metal complexes of an N,N′-disubstituted cyclic thiourea exert significant cytotoxicities to cancer cells and, in particular, the gold(i) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level. © The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/134632
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of the Hong Kong SAR, P.R. ChinaAoE/P-10/01
French Ministry of Foreign Affairs20637NA
Funding Information:

This work was supported by the Area of Excellence Scheme (AoE/P-10/01) established under the University Grants Committee of the Hong Kong SAR, P.R. China. Support of the PROCORE project (French Ministry of Foreign Affairs, Project No. 20637NA) to K.B. and Ryszard Lobinski is acknowledged. We thank Z.-Y. Zhou, N.-Y. Zhu and S.-Y. Chui for crystallography analysis. We also thank J.-S. Huang, Ricky Ho and Raymond Sun for constructive comments.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYan, Ken_HK
dc.contributor.authorLok, CNen_HK
dc.contributor.authorBierla, Ken_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2011-07-04T08:17:22Z-
dc.date.available2011-07-04T08:17:22Z-
dc.date.issued2010en_HK
dc.identifier.citationChemical Communications, 2010, v. 46 n. 41, p. 7691-7693en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134632-
dc.description.abstractCoinage metal complexes of an N,N′-disubstituted cyclic thiourea exert significant cytotoxicities to cancer cells and, in particular, the gold(i) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level. © The Royal Society of Chemistry.en_HK
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.titleGold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=46&issue=41&spage=7691&epage=7693&date=2010&atitle=Gold(I)+complex+of+N,N′-disubstituted+cyclic+thiourea+with+in+vitro+and+in+vivo+anticancer+properties—potent+tight-binding+inhibition+of+thioredoxin+reductase-
dc.identifier.emailLok, CN:cnlok@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLok, CN=rp00752en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c0cc01058hen_HK
dc.identifier.pmid20623063-
dc.identifier.scopuseid_2-s2.0-77957829360en_HK
dc.identifier.hkuros185666-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957829360&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue41en_HK
dc.identifier.spage7691en_HK
dc.identifier.epage7693en_HK
dc.identifier.isiWOS:000282765600004-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridYan, K=35340293700en_HK
dc.identifier.scopusauthoridLok, CN=7006410829en_HK
dc.identifier.scopusauthoridBierla, K=23491632200en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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