File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
  • Basic View
  • Metadata View
  • XML View
TitleThe natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
 
AuthorsLi, IW2
Hung, IF2
To, KK2
Chan, KH2
Wong, SSY2
Chan, JF2
Cheng, VC2
Tsang, OT1
Lai, ST1
Lau, YL2
Yuen, KY2
 
Issue Date2010
 
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
 
CitationChest, 2010, v. 137 n. 4, p. 759-768 [How to Cite?]
DOI: http://dx.doi.org/10.1378/chest.09-3072
 
AbstractBackground; The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain. Methods: A retrospective cohort study involving 145 consecutive palienls with specimens positive by reverse transcriptase-polymerase chain reaction for the matrix and new III genes was conducted. Results: The nonlrealed and osellamivir-trcalcd palienls were comparable in their viral load al presentation, demography, and the presenting symptoms. No correlation was observed between viral load with age and number of symptoms. Viral load of nasopharyngeal aspirate (NPA) was significantly lower in treated than in nonlrealed palienls al day 5 after symptom onset. When oseltamivir was initiated ≤2 days after symptom onset, a greater rate of viral load reduction in NPA of treated patients than that of nontreated patients was observed (-0.838 [95% Cl, -0.809 to -0.466] vs -0.409 [95% CI, -0.863 to -0.1851 log 10 copies/mL/d post-symptom onset), and the viral load was undetectable at day 8 after oseltamivir initiation, which was I day earlier than that of those whose treatment was initiated > 2 days of symptom onset. The viral load was inversely correlated with concomitant absolute lymphocyte count in nontreated patients (Pearson correlation coefficient [r] = -0.687, P = .001) and lrealed palienls (Pearson r = -0.365, P< .001). Resolution of fever was 1.4 days later in nontreated lhan treated palienls (F=.012) Conclusions: The natural viral load profile was described. Oral oseltamivir suppresses viral load more effectively when given early in mild cases of pandemic 2009 influenza A(HlNl) infections. © 2010 American College of Chest Physicians.
 
ISSN0012-3692
2012 Impact Factor: 5.854
2012 SCImago Journal Rankings: 2.031
 
DOIhttp://dx.doi.org/10.1378/chest.09-3072
 
ISI Accession Number IDWOS:000276632400005
Funding AgencyGrant Number
HKSAR
Funding Information:

This study was partially supported by the HKSAR Research Fund for the Control of Infectious Diseases.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, IW
 
dc.contributor.authorHung, IF
 
dc.contributor.authorTo, KK
 
dc.contributor.authorChan, KH
 
dc.contributor.authorWong, SSY
 
dc.contributor.authorChan, JF
 
dc.contributor.authorCheng, VC
 
dc.contributor.authorTsang, OT
 
dc.contributor.authorLai, ST
 
dc.contributor.authorLau, YL
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2011-07-04T03:42:54Z
 
dc.date.available2011-07-04T03:42:54Z
 
dc.date.issued2010
 
dc.description.abstractBackground; The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain. Methods: A retrospective cohort study involving 145 consecutive palienls with specimens positive by reverse transcriptase-polymerase chain reaction for the matrix and new III genes was conducted. Results: The nonlrealed and osellamivir-trcalcd palienls were comparable in their viral load al presentation, demography, and the presenting symptoms. No correlation was observed between viral load with age and number of symptoms. Viral load of nasopharyngeal aspirate (NPA) was significantly lower in treated than in nonlrealed palienls al day 5 after symptom onset. When oseltamivir was initiated ≤2 days after symptom onset, a greater rate of viral load reduction in NPA of treated patients than that of nontreated patients was observed (-0.838 [95% Cl, -0.809 to -0.466] vs -0.409 [95% CI, -0.863 to -0.1851 log 10 copies/mL/d post-symptom onset), and the viral load was undetectable at day 8 after oseltamivir initiation, which was I day earlier than that of those whose treatment was initiated > 2 days of symptom onset. The viral load was inversely correlated with concomitant absolute lymphocyte count in nontreated patients (Pearson correlation coefficient [r] = -0.687, P = .001) and lrealed palienls (Pearson r = -0.365, P< .001). Resolution of fever was 1.4 days later in nontreated lhan treated palienls (F=.012) Conclusions: The natural viral load profile was described. Oral oseltamivir suppresses viral load more effectively when given early in mild cases of pandemic 2009 influenza A(HlNl) infections. © 2010 American College of Chest Physicians.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationChest, 2010, v. 137 n. 4, p. 759-768 [How to Cite?]
DOI: http://dx.doi.org/10.1378/chest.09-3072
 
dc.identifier.doihttp://dx.doi.org/10.1378/chest.09-3072
 
dc.identifier.epage768
 
dc.identifier.hkuros170382
 
dc.identifier.isiWOS:000276632400005
Funding AgencyGrant Number
HKSAR
Funding Information:

This study was partially supported by the HKSAR Research Fund for the Control of Infectious Diseases.

 
dc.identifier.issn0012-3692
2012 Impact Factor: 5.854
2012 SCImago Journal Rankings: 2.031
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid20061398
 
dc.identifier.scopuseid_2-s2.0-77950826918
 
dc.identifier.spage759
 
dc.identifier.urihttp://hdl.handle.net/10722/134630
 
dc.identifier.volume137
 
dc.languageeng
 
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofChest
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntiviral Agents - administration and dosage - therapeutic use
 
dc.subject.meshInfluenza A Virus, H1N1 Subtype - genetics
 
dc.subject.meshInfluenza, Human - drug therapy - epidemiology - virology
 
dc.subject.meshOseltamivir - administration and dosage - therapeutic use
 
dc.subject.meshViral Load
 
dc.titleThe natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Li, IW</contributor.author>
<contributor.author>Hung, IF</contributor.author>
<contributor.author>To, KK</contributor.author>
<contributor.author>Chan, KH</contributor.author>
<contributor.author>Wong, SSY</contributor.author>
<contributor.author>Chan, JF</contributor.author>
<contributor.author>Cheng, VC</contributor.author>
<contributor.author>Tsang, OT</contributor.author>
<contributor.author>Lai, ST</contributor.author>
<contributor.author>Lau, YL</contributor.author>
<contributor.author>Yuen, KY</contributor.author>
<date.accessioned>2011-07-04T03:42:54Z</date.accessioned>
<date.available>2011-07-04T03:42:54Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Chest, 2010, v. 137 n. 4, p. 759-768</identifier.citation>
<identifier.issn>0012-3692</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/134630</identifier.uri>
<description.abstract>Background; The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain. Methods: A retrospective cohort study involving 145 consecutive palienls with specimens positive by reverse transcriptase-polymerase chain reaction for the matrix and new III genes was conducted. Results: The nonlrealed and osellamivir-trcalcd palienls were comparable in their viral load al presentation, demography, and the presenting symptoms. No correlation was observed between viral load with age and number of symptoms. Viral load of nasopharyngeal aspirate (NPA) was significantly lower in treated than in nonlrealed palienls al day 5 after symptom onset. When oseltamivir was initiated &#8804;2 days after symptom onset, a greater rate of viral load reduction in NPA of treated patients than that of nontreated patients was observed (-0.838 [95% Cl, -0.809 to -0.466] vs -0.409 [95% CI, -0.863 to -0.1851 log 10 copies/mL/d post-symptom onset), and the viral load was undetectable at day 8 after oseltamivir initiation, which was I day earlier than that of those whose treatment was initiated &gt; 2 days of symptom onset. The viral load was inversely correlated with concomitant absolute lymphocyte count in nontreated patients (Pearson correlation coefficient [r] = -0.687, P = .001) and lrealed palienls (Pearson r = -0.365, P&lt; .001). Resolution of fever was 1.4 days later in nontreated lhan treated palienls (F=.012) Conclusions: The natural viral load profile was described. Oral oseltamivir suppresses viral load more effectively when given early in mild cases of pandemic 2009 influenza A(HlNl) infections. &#169; 2010 American College of Chest Physicians.</description.abstract>
<language>eng</language>
<publisher>American College of Chest Physicians. The Journal&apos;s web site is located at http://www.chestjournal.org</publisher>
<relation.ispartof>Chest</relation.ispartof>
<subject.mesh>Antiviral Agents - administration and dosage - therapeutic use</subject.mesh>
<subject.mesh>Influenza A Virus, H1N1 Subtype - genetics</subject.mesh>
<subject.mesh>Influenza, Human - drug therapy - epidemiology - virology</subject.mesh>
<subject.mesh>Oseltamivir - administration and dosage - therapeutic use</subject.mesh>
<subject.mesh>Viral Load</subject.mesh>
<title>The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0012-3692&amp;volume=137&amp;issue=4&amp;spage=759&amp;epage=768&amp;date=2010&amp;atitle=The+natural+viral+load+profile+of+patients+with+pandemic+2009+influenza+A(H1N1)+and+the+effect+of+oseltamivir+treatment</identifier.openurl>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1378/chest.09-3072</identifier.doi>
<identifier.pmid>20061398</identifier.pmid>
<identifier.scopus>eid_2-s2.0-77950826918</identifier.scopus>
<identifier.hkuros>170382</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950826918&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>137</identifier.volume>
<identifier.issue>4</identifier.issue>
<identifier.spage>759</identifier.spage>
<identifier.epage>768</identifier.epage>
<identifier.isi>WOS:000276632400005</identifier.isi>
<publisher.place>United States</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/134630/2/re01.html</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong