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Article: The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment

TitleThe natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
Authors
Issue Date2010
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2010, v. 137 n. 4, p. 759-768 How to Cite?
AbstractBackground; The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain. Methods: A retrospective cohort study involving 145 consecutive palienls with specimens positive by reverse transcriptase-polymerase chain reaction for the matrix and new III genes was conducted. Results: The nonlrealed and osellamivir-trcalcd palienls were comparable in their viral load al presentation, demography, and the presenting symptoms. No correlation was observed between viral load with age and number of symptoms. Viral load of nasopharyngeal aspirate (NPA) was significantly lower in treated than in nonlrealed palienls al day 5 after symptom onset. When oseltamivir was initiated ≤2 days after symptom onset, a greater rate of viral load reduction in NPA of treated patients than that of nontreated patients was observed (-0.838 [95% Cl, -0.809 to -0.466] vs -0.409 [95% CI, -0.863 to -0.1851 log 10 copies/mL/d post-symptom onset), and the viral load was undetectable at day 8 after oseltamivir initiation, which was I day earlier than that of those whose treatment was initiated > 2 days of symptom onset. The viral load was inversely correlated with concomitant absolute lymphocyte count in nontreated patients (Pearson correlation coefficient [r] = -0.687, P = .001) and lrealed palienls (Pearson r = -0.365, P< .001). Resolution of fever was 1.4 days later in nontreated lhan treated palienls (F=.012) Conclusions: The natural viral load profile was described. Oral oseltamivir suppresses viral load more effectively when given early in mild cases of pandemic 2009 influenza A(HlNl) infections. © 2010 American College of Chest Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/134630
ISSN
2014 Impact Factor: 7.483
2014 SCImago Journal Rankings: 2.636
ISI Accession Number ID
Funding AgencyGrant Number
HKSAR
Funding Information:

This study was partially supported by the HKSAR Research Fund for the Control of Infectious Diseases.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, IWen_HK
dc.contributor.authorHung, IFen_HK
dc.contributor.authorTo, KKen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorChan, JFen_HK
dc.contributor.authorCheng, VCen_HK
dc.contributor.authorTsang, OTen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2011-07-04T03:42:54Z-
dc.date.available2011-07-04T03:42:54Z-
dc.date.issued2010en_HK
dc.identifier.citationChest, 2010, v. 137 n. 4, p. 759-768en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134630-
dc.description.abstractBackground; The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain. Methods: A retrospective cohort study involving 145 consecutive palienls with specimens positive by reverse transcriptase-polymerase chain reaction for the matrix and new III genes was conducted. Results: The nonlrealed and osellamivir-trcalcd palienls were comparable in their viral load al presentation, demography, and the presenting symptoms. No correlation was observed between viral load with age and number of symptoms. Viral load of nasopharyngeal aspirate (NPA) was significantly lower in treated than in nonlrealed palienls al day 5 after symptom onset. When oseltamivir was initiated ≤2 days after symptom onset, a greater rate of viral load reduction in NPA of treated patients than that of nontreated patients was observed (-0.838 [95% Cl, -0.809 to -0.466] vs -0.409 [95% CI, -0.863 to -0.1851 log 10 copies/mL/d post-symptom onset), and the viral load was undetectable at day 8 after oseltamivir initiation, which was I day earlier than that of those whose treatment was initiated > 2 days of symptom onset. The viral load was inversely correlated with concomitant absolute lymphocyte count in nontreated patients (Pearson correlation coefficient [r] = -0.687, P = .001) and lrealed palienls (Pearson r = -0.365, P< .001). Resolution of fever was 1.4 days later in nontreated lhan treated palienls (F=.012) Conclusions: The natural viral load profile was described. Oral oseltamivir suppresses viral load more effectively when given early in mild cases of pandemic 2009 influenza A(HlNl) infections. © 2010 American College of Chest Physicians.en_HK
dc.languageeng-
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.subject.meshAntiviral Agents - administration and dosage - therapeutic use-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - genetics-
dc.subject.meshInfluenza, Human - drug therapy - epidemiology - virology-
dc.subject.meshOseltamivir - administration and dosage - therapeutic use-
dc.subject.meshViral Load-
dc.titleThe natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=137&issue=4&spage=759&epage=768&date=2010&atitle=The+natural+viral+load+profile+of+patients+with+pandemic+2009+influenza+A(H1N1)+and+the+effect+of+oseltamivir+treatment-
dc.identifier.emailHung, IF: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailTo, KK: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailWong, SSY: samsonsy@hkucc.hku.hken_HK
dc.identifier.emailChan, JF: jfwchan@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHung, IF=rp00508en_HK
dc.identifier.authorityTo, KK=rp01384en_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.identifier.authorityChan, JF=rp01736en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1378/chest.09-3072en_HK
dc.identifier.pmid20061398-
dc.identifier.scopuseid_2-s2.0-77950826918en_HK
dc.identifier.hkuros170382-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950826918&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue4en_HK
dc.identifier.spage759en_HK
dc.identifier.epage768en_HK
dc.identifier.isiWOS:000276632400005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, IW=24464179500en_HK
dc.identifier.scopusauthoridHung, IF=7006103457en_HK
dc.identifier.scopusauthoridTo, KK=14323807300en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridChan, JF=24278817900en_HK
dc.identifier.scopusauthoridCheng, VC=38662328400en_HK
dc.identifier.scopusauthoridTsang, OT=6602450830en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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