Article: Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
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- Publisher Website: 10.1111/j.1349-7006.2010.01560.x
- Scopus: eid_2-s2.0-77954153940
- PMID: 20367640
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| Title | Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Cai, M1 2 Zhang, B2 He, W3 Yang, G3 Rao, H1 2 Rao, Z2 Wu, Q1 Guan, X2 Kung, H2 Zeng, Y2 Xie, D2 | ||||||||
| Issue Date | 2010 | ||||||||
| Publisher | Blackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS | ||||||||
| Citation | Cancer Science, 2010, v. 101 n. 6, p. 1543-1549 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x | ||||||||
| Abstract | Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association. | ||||||||
| ISSN | 1347-9032 2011 Impact Factor: 3.325 2011 SCImago Journal Rankings: 0.442 | ||||||||
| DOI | http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x | ||||||||
| ISI Accession Number ID | WOS:000277913800029
Funding Information: This study was supported by grants from the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (no. 30772334 and 30901769), and the 863 Project of China (2007AA021901). | ||||||||
| References | References in Scopus |
| dc.contributor.author | Cai, M | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhang, B | ||||||||
| dc.contributor.author | He, W | ||||||||
| dc.contributor.author | Yang, G | ||||||||
| dc.contributor.author | Rao, H | ||||||||
| dc.contributor.author | Rao, Z | ||||||||
| dc.contributor.author | Wu, Q | ||||||||
| dc.contributor.author | Guan, X | ||||||||
| dc.contributor.author | Kung, H | ||||||||
| dc.contributor.author | Zeng, Y | ||||||||
| dc.contributor.author | Xie, D | ||||||||
| dc.date.accessioned | 2011-06-28T04:21:48Z | ||||||||
| dc.date.available | 2011-06-28T04:21:48Z | ||||||||
| dc.date.issued | 2010 | ||||||||
| dc.description.abstract | Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association. | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Cancer Science, 2010, v. 101 n. 6, p. 1543-1549 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x | ||||||||
| dc.identifier.citeulike | 7240950 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x | ||||||||
| dc.identifier.epage | 1549 | ||||||||
| dc.identifier.hkuros | 183176 | ||||||||
| dc.identifier.isi | WOS:000277913800029
Funding Information: This study was supported by grants from the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (no. 30772334 and 30901769), and the 863 Project of China (2007AA021901). | ||||||||
| dc.identifier.issn | 1347-9032 2011 Impact Factor: 3.325 2011 SCImago Journal Rankings: 0.442 | ||||||||
| dc.identifier.issue | 6 | ||||||||
| dc.identifier.openurl | | ||||||||
| dc.identifier.pmid | 20367640 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-77954153940 | ||||||||
| dc.identifier.spage | 1543 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/134616 | ||||||||
| dc.identifier.volume | 101 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Blackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS | ||||||||
| dc.publisher.place | Japan | ||||||||
| dc.relation.ispartof | Cancer Science | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.rights | The definitive version is available at www.blackwell-synergy.com | ||||||||
| dc.subject.mesh | Immunohistochemistry | ||||||||
| dc.subject.mesh | Neoplasms, Glandular and Epithelial - etiology - mortality - pathology | ||||||||
| dc.subject.mesh | Ovarian Neoplasms - etiology - mortality - pathology | ||||||||
| dc.subject.mesh | Prognosis | ||||||||
| dc.subject.mesh | Tumor Suppressor Proteins - analysis - physiology | ||||||||
| dc.title | Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma | ||||||||
| dc.type | Article |
Author Affiliations
- Cancer Center
- Sun Yat-Sen University Cancer Center
- Sun Yat-Sen University