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Article: Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
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TitleDecreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
 
AuthorsCai, M2 1
Zhang, B2
He, W3
Yang, G3
Rao, H2 1
Rao, Z2
Wu, Q1
Guan, X2
Kung, H2
Zeng, Y2
Xie, D2
 
Issue Date2010
 
PublisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
 
CitationCancer Science, 2010, v. 101 n. 6, p. 1543-1549 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x
 
AbstractHuman interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association.
 
ISSN1347-9032
 
DOIhttp://dx.doi.org/10.1111/j.1349-7006.2010.01560.x
 
ISI Accession Number IDWOS:000277913800029
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
30901769
863 Project of China2007AA021901
Funding Information:

This study was supported by grants from the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (no. 30772334 and 30901769), and the 863 Project of China (2007AA021901).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCai, M
 
dc.contributor.authorZhang, B
 
dc.contributor.authorHe, W
 
dc.contributor.authorYang, G
 
dc.contributor.authorRao, H
 
dc.contributor.authorRao, Z
 
dc.contributor.authorWu, Q
 
dc.contributor.authorGuan, X
 
dc.contributor.authorKung, H
 
dc.contributor.authorZeng, Y
 
dc.contributor.authorXie, D
 
dc.date.accessioned2011-06-28T04:21:48Z
 
dc.date.available2011-06-28T04:21:48Z
 
dc.date.issued2010
 
dc.description.abstractHuman interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Science, 2010, v. 101 n. 6, p. 1543-1549 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1349-7006.2010.01560.x
 
dc.identifier.citeulike7240950
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1349-7006.2010.01560.x
 
dc.identifier.epage1549
 
dc.identifier.hkuros183176
 
dc.identifier.isiWOS:000277913800029
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
30901769
863 Project of China2007AA021901
Funding Information:

This study was supported by grants from the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (no. 30772334 and 30901769), and the 863 Project of China (2007AA021901).

 
dc.identifier.issn1347-9032
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid20367640
 
dc.identifier.scopuseid_2-s2.0-77954153940
 
dc.identifier.spage1543
 
dc.identifier.urihttp://hdl.handle.net/10722/134616
 
dc.identifier.volume101
 
dc.languageeng
 
dc.publisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
 
dc.publisher.placeJapan
 
dc.relation.ispartofCancer Science
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshNeoplasms, Glandular and Epithelial - etiology - mortality - pathology
 
dc.subject.meshOvarian Neoplasms - etiology - mortality - pathology
 
dc.subject.meshPrognosis
 
dc.subject.meshTumor Suppressor Proteins - analysis - physiology
 
dc.titleDecreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. Cancer Center
  2. Sun Yat-Sen University Cancer Center
  3. Sun Yat-Sen University