File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma

TitleDecreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
Authors
Issue Date2010
PublisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
Citation
Cancer Science, 2010, v. 101 n. 6, p. 1543-1549 How to Cite?
Abstract
Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association.
Persistent Identifierhttp://hdl.handle.net/10722/134616
ISSN
ISI Accession Number ID
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
30901769
863 Project of China2007AA021901
Funding Information:

This study was supported by grants from the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (no. 30772334 and 30901769), and the 863 Project of China (2007AA021901).

References

 

Author Affiliations
  1. Cancer Center
  2. Sun Yat-Sen University Cancer Center
  3. Sun Yat-Sen University
DC FieldValueLanguage
dc.contributor.authorCai, Men_HK
dc.contributor.authorZhang, Ben_HK
dc.contributor.authorHe, Wen_HK
dc.contributor.authorYang, Gen_HK
dc.contributor.authorRao, Hen_HK
dc.contributor.authorRao, Zen_HK
dc.contributor.authorWu, Qen_HK
dc.contributor.authorGuan, Xen_HK
dc.contributor.authorKung, Hen_HK
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorXie, Den_HK
dc.date.accessioned2011-06-28T04:21:48Z-
dc.date.available2011-06-28T04:21:48Z-
dc.date.issued2010en_HK
dc.identifier.citationCancer Science, 2010, v. 101 n. 6, p. 1543-1549en_HK
dc.identifier.issn1347-9032en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134616-
dc.description.abstractHuman interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver-operator curve (ROC) analysis was used to determine cut-off scores for tumor positivity and to evaluate patients' survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P < 0.001) based on the area under the ROC. Positive expression of PinX1 was observed in 100% of normal ovarian tissues, in 84% of cystadenomas, in 75.9% borderline tumors, and 66.2% of ovarian carcinomas. Decreased expression of PinX1 was strongly related to patients with poor prognostic factors regarding presence of lymph node metastasis (P = 0.024), distant metastasis (P < 0.001), and late International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001). In univariate survival analysis, a highly significant correlation between loss of PinX1 and shortened patient survival (mean, 48.2 months vs 99.2 months, P < 0.001) was displayed. Multivariate analysis demonstrated PinX1 expression (P = 0.027) was evaluated as an independent parameter. Our findings suggest that loss of PinX1 is an adverse independent molecular marker for epithelial ovarian carcinoma patients. PinX1 may be a novel target for telomerase-based anticancer therapy due to inhibiting telomerase activity. (Cancer Sci 2010). © 2010 Japanese Cancer Association.en_HK
dc.languageeng-
dc.publisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CASen_HK
dc.relation.ispartofCancer Scienceen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshImmunohistochemistry-
dc.subject.meshNeoplasms, Glandular and Epithelial - etiology - mortality - pathology-
dc.subject.meshOvarian Neoplasms - etiology - mortality - pathology-
dc.subject.meshPrognosis-
dc.subject.meshTumor Suppressor Proteins - analysis - physiology-
dc.titleDecreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1347-9032&volume=101&issue=6&spage=1543&epage=1549&date=2010&atitle=Decreased+expression+of+PinX1+protein+is+correlated+with+tumor+development+and+is+a+new+independent+poor+prognostic+factor+in+ovarian+carcinoma-
dc.identifier.emailGuan, X:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, X=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1349-7006.2010.01560.xen_HK
dc.identifier.pmid20367640en_HK
dc.identifier.scopuseid_2-s2.0-77954153940en_HK
dc.identifier.hkuros183176-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954153940&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1543en_HK
dc.identifier.epage1549en_HK
dc.identifier.isiWOS:000277913800029-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridCai, M=23388510500en_HK
dc.identifier.scopusauthoridZhang, B=7406908582en_HK
dc.identifier.scopusauthoridHe, W=35185088700en_HK
dc.identifier.scopusauthoridYang, G=16064823400en_HK
dc.identifier.scopusauthoridRao, H=35277843000en_HK
dc.identifier.scopusauthoridRao, Z=36187169500en_HK
dc.identifier.scopusauthoridWu, Q=7404602639en_HK
dc.identifier.scopusauthoridGuan, X=7201463221en_HK
dc.identifier.scopusauthoridKung, H=7402514190en_HK
dc.identifier.scopusauthoridZeng, Y=7402981579en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.citeulike7240950-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats