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Article: Generation of induced pluripotent stem cells from urine

TitleGeneration of induced pluripotent stem cells from urine
Authors
Issue Date2011
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
Journal Of The American Society Of Nephrology, 2011, v. 22 n. 7, p. 1221-1228 How to Cite?
AbstractForced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor cells for reprogramming into iPSCs, and some donor cell types may be more prone than others to accumulation of epigenetic imprints and somatic cell mutations. Here, we present a simple, reproducible, noninvasive method for generating human iPSCs from renal tubular cells present in urine. This procedure eliminates many problems associated with other protocols, and the resulting iPSCs display an excellent ability to differentiate. These data suggest that urine may be a preferred source for generating iPSCs. Copyright © 2011 by the American Society of Nephrology.
DescriptionComment in J Am Soc Nephrol. 2011 Jul;22(7):1179-1180
Persistent Identifierhttp://hdl.handle.net/10722/134440
ISSN
2015 Impact Factor: 8.491
2015 SCImago Journal Rankings: 4.699
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Ministry of Science and Technology of China2011CB965200
Chinese Academy of SciencesKSCX2-YW-R244
KSCX2-YW-G-075 to 18
Ministry of Science and Technology China2007CB948002
Ministry of Science and Technology International Technology Cooperation Program2010DFB30430
Bureau of Science and Technology of Guangzhou Municipality, China2010U1-E00521
Austrian Science FundS93-06
Genome Research Austria GEN-AU820982
Funding Information:

This work was supported by grants from the 973 program of Ministry of Science and Technology of China (2011CB965200) and Chinese Academy of Sciences (KSCX2-YW-R244) to M.A.E.; by grants from the 973 Program of Ministry of Science and Technology China (2007CB948002), Ministry of Science and Technology International Technology Cooperation Program (2010DFB30430), Knowledge Innovation Project of The Chinese Academy of Sciences KSCX2-YW-G-075 to 18, and Bureau of Science and Technology of Guangzhou Municipality, China (2010U1-E00521) to D.P.; and by grants by the Austrian Science Fund (S93-06) and Genome Research Austria GEN-AU (820982) to J.G. and R.G.-V. We thank all members of our laboratories for helpful suggestions. J.G. and R.G.-V. are recent cofounders and directors of Evercyte.

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Ten_HK
dc.contributor.authorBenda, Cen_HK
dc.contributor.authorDuzinger, Sen_HK
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorGuo, Xen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorHao, Len_HK
dc.contributor.authorChan, YCen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorWieser, Men_HK
dc.contributor.authorWu, Jen_HK
dc.contributor.authorRedl, Hen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorGrillari, Jen_HK
dc.contributor.authorGrillariVoglauer, Ren_HK
dc.contributor.authorPei, Den_HK
dc.contributor.authorEsteban, MAen_HK
dc.date.accessioned2011-06-17T09:20:40Z-
dc.date.available2011-06-17T09:20:40Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of The American Society Of Nephrology, 2011, v. 22 n. 7, p. 1221-1228en_HK
dc.identifier.issn1046-6673en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134440-
dc.descriptionComment in J Am Soc Nephrol. 2011 Jul;22(7):1179-1180-
dc.description.abstractForced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor cells for reprogramming into iPSCs, and some donor cell types may be more prone than others to accumulation of epigenetic imprints and somatic cell mutations. Here, we present a simple, reproducible, noninvasive method for generating human iPSCs from renal tubular cells present in urine. This procedure eliminates many problems associated with other protocols, and the resulting iPSCs display an excellent ability to differentiate. These data suggest that urine may be a preferred source for generating iPSCs. Copyright © 2011 by the American Society of Nephrology.en_HK
dc.languageengen_US
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.orgen_HK
dc.relation.ispartofJournal of the American Society of Nephrologyen_HK
dc.subject.meshAged-
dc.subject.meshGene Transfer Techniques-
dc.subject.meshInduced Pluripotent Stem Cells-
dc.subject.meshKidney Tubules - cytology-
dc.subject.meshUrine - cytology-
dc.titleGeneration of induced pluripotent stem cells from urineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1046-6673&volume=22&issue=7&spage=1221&epage=1228&date=2011&atitle=Generation+of+induced+pluripotent+stem+cells+from+urine-
dc.identifier.emailChan, YC: ycchan09@hku.hken_HK
dc.identifier.emailNg, KM: skykmng@hkucc.hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YC=rp01502en_HK
dc.identifier.authorityNg, KM=rp01670en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1681/ASN.2011010106en_HK
dc.identifier.pmid21636641-
dc.identifier.pmcidPMC3137570-
dc.identifier.scopuseid_2-s2.0-79960122427en_HK
dc.identifier.hkuros185836en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960122427&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1221en_HK
dc.identifier.epage1228en_HK
dc.identifier.isiWOS:000293203400010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f100011414969-
dc.identifier.scopusauthoridZhou, T=36543304400en_HK
dc.identifier.scopusauthoridBenda, C=51161101800en_HK
dc.identifier.scopusauthoridDuzinger, S=42661157200en_HK
dc.identifier.scopusauthoridHuang, Y=51161390100en_HK
dc.identifier.scopusauthoridLi, X=51161444600en_HK
dc.identifier.scopusauthoridLi, Y=51161428400en_HK
dc.identifier.scopusauthoridGuo, X=36463626600en_HK
dc.identifier.scopusauthoridCao, G=51160980200en_HK
dc.identifier.scopusauthoridChen, S=51161034100en_HK
dc.identifier.scopusauthoridHao, L=36618854800en_HK
dc.identifier.scopusauthoridChan, YC=7403676116en_HK
dc.identifier.scopusauthoridNg, KM=25122990200en_HK
dc.identifier.scopusauthoridHo, JC=51161388200en_HK
dc.identifier.scopusauthoridWieser, M=12041795200en_HK
dc.identifier.scopusauthoridWu, J=38062450100en_HK
dc.identifier.scopusauthoridRedl, H=7101771621en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridGrillari, J=6507010731en_HK
dc.identifier.scopusauthoridGrillariVoglauer, R=25824969900en_HK
dc.identifier.scopusauthoridPei, D=7102806599en_HK
dc.identifier.scopusauthoridEsteban, MA=35591774300en_HK
dc.identifier.citeulike10689762-

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