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Article: Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
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TitleAnti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
 
AuthorsLaw, EWL1
Cheung, AKL1
Kashuba, VI6
Pavlova, TV6
Zabarovsky, ER6 3
Lung, HL1
Cheng, Y1
Chua, D1 5
LaiWan Kwong, D1
Tsao, SW1
Sasaki, T4
Stanbridge, EJ2
Lung, ML1
 
Keywordsanti-angiogenic
fibulin-2
methylation
nasopharyngeal carcinoma
tumor suppressor
VEGF
 
Issue Date2012
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
 
CitationOncogene, 2012, v. 31 n. 6, p. 728-738 [How to Cite?]
DOI: http://dx.doi.org/10.1038/onc.2011.272
 
AbstractFibulin-2 (FBLN2) has been identified as a candidate tumor-suppressor gene in nasopharyngeal carcinoma (NPC). Originally identified through a chromosome 3 NotI genomic microarray screen, it shows frequent deletion or methylation in NPC. FBLN2 is located on chromosome 3p25.1 and is associated with tumor development through its important interactions with the extracellular matrix (ECM) proteins. FBLN2 encodes two isoforms. The short isoform (FBLN2S) is expressed abundantly in normal tissues, but is dramatically downregulated in NPC, while the long isoform (FBLN2L) is either not detectable or is expressed only at low levels in both normal and tumor tissues. Reintroduction of this FBLN2S inhibited cell proliferation, migration, invasion and angiogenesis in vitro. Furthermore, in vivo studies in nude mice show its expression is associated with tumor and angiogenesis suppression. FBLN2-associated angiogenesis occurs via concomitant downregulation of vascular endothelial growth factor and matrix metalloproteinase 2. This study provides compelling evidence that FBLN2S has an important tumor-suppressive and anti-angiogenic role in NPC. © 2012 Macmillan Publishers Limited All rights reserved.
 
ISSN0950-9232
2012 Impact Factor: 7.357
2012 SCImago Journal Rankings: 3.558
 
DOIhttp://dx.doi.org/10.1038/onc.2011.272
 
ISI Accession Number IDWOS:000300222100006
Funding AgencyGrant Number
University Grants CouncilAoE/M-06/08
Swedish Cancer Society
Swedish Research Council
Swedish Institute
Karolinska Institute
Funding Information:

This work was supported by University Grants Council Area of Excellence grant AoE/M-06/08 to MLL and the Swedish Cancer Society, the Swedish Research Council, the Swedish Institute, and Karolinska Institute to ERZ.

 
ReferencesReferences in Scopus
 
GrantsCentre for Nasopharyngeal Carcinoma Research
 
DC FieldValue
dc.contributor.authorLaw, EWL
 
dc.contributor.authorCheung, AKL
 
dc.contributor.authorKashuba, VI
 
dc.contributor.authorPavlova, TV
 
dc.contributor.authorZabarovsky, ER
 
dc.contributor.authorLung, HL
 
dc.contributor.authorCheng, Y
 
dc.contributor.authorChua, D
 
dc.contributor.authorLaiWan Kwong, D
 
dc.contributor.authorTsao, SW
 
dc.contributor.authorSasaki, T
 
dc.contributor.authorStanbridge, EJ
 
dc.contributor.authorLung, ML
 
dc.date.accessioned2011-06-17T09:19:16Z
 
dc.date.available2011-06-17T09:19:16Z
 
dc.date.issued2012
 
dc.description.abstractFibulin-2 (FBLN2) has been identified as a candidate tumor-suppressor gene in nasopharyngeal carcinoma (NPC). Originally identified through a chromosome 3 NotI genomic microarray screen, it shows frequent deletion or methylation in NPC. FBLN2 is located on chromosome 3p25.1 and is associated with tumor development through its important interactions with the extracellular matrix (ECM) proteins. FBLN2 encodes two isoforms. The short isoform (FBLN2S) is expressed abundantly in normal tissues, but is dramatically downregulated in NPC, while the long isoform (FBLN2L) is either not detectable or is expressed only at low levels in both normal and tumor tissues. Reintroduction of this FBLN2S inhibited cell proliferation, migration, invasion and angiogenesis in vitro. Furthermore, in vivo studies in nude mice show its expression is associated with tumor and angiogenesis suppression. FBLN2-associated angiogenesis occurs via concomitant downregulation of vascular endothelial growth factor and matrix metalloproteinase 2. This study provides compelling evidence that FBLN2S has an important tumor-suppressive and anti-angiogenic role in NPC. © 2012 Macmillan Publishers Limited All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationOncogene, 2012, v. 31 n. 6, p. 728-738 [How to Cite?]
DOI: http://dx.doi.org/10.1038/onc.2011.272
 
dc.identifier.citeulike9543910
 
dc.identifier.doihttp://dx.doi.org/10.1038/onc.2011.272
 
dc.identifier.eissn1476-5594
 
dc.identifier.epage738
 
dc.identifier.hkuros185871
 
dc.identifier.isiWOS:000300222100006
Funding AgencyGrant Number
University Grants CouncilAoE/M-06/08
Swedish Cancer Society
Swedish Research Council
Swedish Institute
Karolinska Institute
Funding Information:

This work was supported by University Grants Council Area of Excellence grant AoE/M-06/08 to MLL and the Swedish Cancer Society, the Swedish Research Council, the Swedish Institute, and Karolinska Institute to ERZ.

 
dc.identifier.issn0950-9232
2012 Impact Factor: 7.357
2012 SCImago Journal Rankings: 3.558
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid21743496
 
dc.identifier.scopuseid_2-s2.0-84856949774
 
dc.identifier.spage728
 
dc.identifier.urihttp://hdl.handle.net/10722/134395
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofOncogene
 
dc.relation.projectCentre for Nasopharyngeal Carcinoma Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectanti-angiogenic
 
dc.subjectfibulin-2
 
dc.subjectmethylation
 
dc.subjectnasopharyngeal carcinoma
 
dc.subjecttumor suppressor
 
dc.subjectVEGF
 
dc.titleAnti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. UC Irvine
  3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
  4. null
  5. Hong Kong Sanatorium and Hospital
  6. Södersjukhuset