Article: Efficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives

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TitleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
AuthorsLai, SW2
Liu, Y1
Zhang, D1
Wang, B2
Lok, CN2
Che, CM2
Selke, M1
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/home
CitationPhotochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
AbstractLuminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.
ISSN0031-8655
2011 Impact Factor: 2.413
2011 SCImago Journal Rankings: 0.277
DOIhttp://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
PubMed Central IDPMC3071644
ReferencesReferences in Scopus
GrantsSelf-assembled metal coordination polymers and supramolecular systems containing π-conjugated organic ligands
Phosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications
DC Field
Value
dc.contributor.authorLai, SW
dc.contributor.authorLiu, Y
dc.contributor.authorZhang, D
dc.contributor.authorWang, B
dc.contributor.authorLok, CN
dc.contributor.authorChe, CM
dc.contributor.authorSelke, M
dc.date.accessioned2011-06-17T09:18:56Z
dc.date.available2011-06-17T09:18:56Z
dc.date.issued2010
dc.description.abstractLuminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.
dc.description.grantSelf-assembled metal coordination polymers and supramolecular systems containing π-conjugated organic ligands
dc.description.grantPhosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications
dc.description.grantcode99415
dc.description.grantcode82627
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationPhotochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
dc.identifier.doihttp://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
dc.identifier.epage1420
dc.identifier.hkuros185849
dc.identifier.isiWOS:000284429500032
Funding AgencyGrant Number
Research Grant Council of the Hong Kong SAR, ChinaHKU 7030/06P
University of Hong Kong
Chinese Academy of Sciences-Croucher Foundation
National Natural Science Foundation of China/Research Grants CouncilN_HKU 752/08
NIH-NIGMSSC1GM084776
NSF CRESTNSF HRD-0932421
Funding Information:

We are grateful for financial support from the Research Grant Council of the Hong Kong SAR, China (HKU 7030/06P), The University of Hong Kong, The Chinese Academy of Sciences-Croucher Foundation Funding Scheme for Joint Laboratories, and the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme (N_HKU 752/08). Y. L., D. Z. and M. S. gratefully acknowledge support from the NIH-NIGMS SC1GM084776 and the NSF CREST program (NSF HRD-0932421).

dc.identifier.issn0031-8655
2011 Impact Factor: 2.413
2011 SCImago Journal Rankings: 0.277
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmcidPMC3071644
dc.identifier.pmid21155073
dc.identifier.scopuseid_2-s2.0-78649684211
dc.identifier.spage1414
dc.identifier.urihttp://hdl.handle.net/10722/134390
dc.identifier.volume86
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/home
dc.publisher.placeUnited States
dc.relation.ispartofPhotochemistry and Photobiology
dc.relation.referencesReferences in Scopus
dc.rightsThe definitive version is available at www3.interscience.wiley.com
dc.subject.meshCalixarenes - chemistry - pharmacology
dc.subject.meshCattle
dc.subject.meshOrganoplatinum Compounds - chemistry - pharmacology
dc.subject.meshPhotosensitizing Agents - chemistry - pharmacology
dc.subject.meshSinglet Oxygen - chemistry
dc.titleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
dc.typeArticle
Author Affiliations
  1. California State University Los Angeles
  2. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong