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Article: Efficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives

TitleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/home
Citation
Photochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420 How to Cite?
Abstract
Luminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.
Persistent Identifierhttp://hdl.handle.net/10722/134390
ISSN
2013 Impact Factor: 2.684
2013 SCImago Journal Rankings: 0.764
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council of the Hong Kong SAR, ChinaHKU 7030/06P
University of Hong Kong
Chinese Academy of Sciences-Croucher Foundation
National Natural Science Foundation of China/Research Grants CouncilN_HKU 752/08
NIH-NIGMSSC1GM084776
NSF CRESTNSF HRD-0932421
Funding Information:

We are grateful for financial support from the Research Grant Council of the Hong Kong SAR, China (HKU 7030/06P), The University of Hong Kong, The Chinese Academy of Sciences-Croucher Foundation Funding Scheme for Joint Laboratories, and the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme (N_HKU 752/08). Y. L., D. Z. and M. S. gratefully acknowledge support from the NIH-NIGMS SC1GM084776 and the NSF CREST program (NSF HRD-0932421).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLai, SWen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZhang, Den_HK
dc.contributor.authorWang, Ben_HK
dc.contributor.authorLok, CNen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorSelke, Men_HK
dc.date.accessioned2011-06-17T09:18:56Z-
dc.date.available2011-06-17T09:18:56Z-
dc.date.issued2010en_HK
dc.identifier.citationPhotochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420en_HK
dc.identifier.issn0031-8655en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134390-
dc.description.abstractLuminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/homeen_HK
dc.relation.ispartofPhotochemistry and Photobiologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshCalixarenes - chemistry - pharmacology-
dc.subject.meshCattle-
dc.subject.meshOrganoplatinum Compounds - chemistry - pharmacology-
dc.subject.meshPhotosensitizing Agents - chemistry - pharmacology-
dc.subject.meshSinglet Oxygen - chemistry-
dc.titleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivativesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-8655&volume=86&issue=6&spage=1414&epage=1420&date=2010&atitle=Efficient+singlet+oxygen+generation+by+luminescent+2-(2′-thienyl)pyridyl+cyclometalated+platinum(II)+complexes+and+their+calixarene+derivatives-
dc.identifier.emailLok, CN:cnlok@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLok, CN=rp00752en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1751-1097.2010.00809.xen_HK
dc.identifier.pmid21155073en_HK
dc.identifier.pmcidPMC3071644-
dc.identifier.scopuseid_2-s2.0-78649684211en_HK
dc.identifier.hkuros185849en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649684211&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1414en_HK
dc.identifier.epage1420en_HK
dc.identifier.isiWOS:000284429500032-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectSelf-assembled metal coordination polymers and supramolecular systems containing π-conjugated organic ligands-
dc.relation.projectPhosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications-
dc.identifier.scopusauthoridLai, SW=55104882100en_HK
dc.identifier.scopusauthoridLiu, Y=36071871200en_HK
dc.identifier.scopusauthoridZhang, D=12646277200en_HK
dc.identifier.scopusauthoridWang, B=37071541800en_HK
dc.identifier.scopusauthoridLok, CN=7006410829en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridSelke, M=6701404311en_HK

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