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Article: Efficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
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TitleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
 
AuthorsLai, SW2
Liu, Y1
Zhang, D1
Wang, B2
Lok, CN2
Che, CM2
Selke, M1
 
Issue Date2010
 
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/home
 
CitationPhotochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
 
AbstractLuminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.
 
ISSN0031-8655
2013 Impact Factor: 2.684
2013 SCImago Journal Rankings: 0.764
 
DOIhttp://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
 
PubMed Central IDPMC3071644
 
ISI Accession Number IDWOS:000284429500032
Funding AgencyGrant Number
Research Grant Council of the Hong Kong SAR, ChinaHKU 7030/06P
University of Hong Kong
Chinese Academy of Sciences-Croucher Foundation
National Natural Science Foundation of China/Research Grants CouncilN_HKU 752/08
NIH-NIGMSSC1GM084776
NSF CRESTNSF HRD-0932421
Funding Information:

We are grateful for financial support from the Research Grant Council of the Hong Kong SAR, China (HKU 7030/06P), The University of Hong Kong, The Chinese Academy of Sciences-Croucher Foundation Funding Scheme for Joint Laboratories, and the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme (N_HKU 752/08). Y. L., D. Z. and M. S. gratefully acknowledge support from the NIH-NIGMS SC1GM084776 and the NSF CREST program (NSF HRD-0932421).

 
ReferencesReferences in Scopus
 
GrantsSelf-assembled metal coordination polymers and supramolecular systems containing π-conjugated organic ligands
Phosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications
 
DC FieldValue
dc.contributor.authorLai, SW
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorZhang, D
 
dc.contributor.authorWang, B
 
dc.contributor.authorLok, CN
 
dc.contributor.authorChe, CM
 
dc.contributor.authorSelke, M
 
dc.date.accessioned2011-06-17T09:18:56Z
 
dc.date.available2011-06-17T09:18:56Z
 
dc.date.issued2010
 
dc.description.abstractLuminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh 3)X] n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl - (1), n = 0; X = CH 3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y] n+ (Y = Cl - (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria. © 2010 The Authors. Journal Compilation. The American Society of Photobiology.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationPhotochemistry And Photobiology, 2010, v. 86 n. 6, p. 1414-1420 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1751-1097.2010.00809.x
 
dc.identifier.epage1420
 
dc.identifier.hkuros185849
 
dc.identifier.isiWOS:000284429500032
Funding AgencyGrant Number
Research Grant Council of the Hong Kong SAR, ChinaHKU 7030/06P
University of Hong Kong
Chinese Academy of Sciences-Croucher Foundation
National Natural Science Foundation of China/Research Grants CouncilN_HKU 752/08
NIH-NIGMSSC1GM084776
NSF CRESTNSF HRD-0932421
Funding Information:

We are grateful for financial support from the Research Grant Council of the Hong Kong SAR, China (HKU 7030/06P), The University of Hong Kong, The Chinese Academy of Sciences-Croucher Foundation Funding Scheme for Joint Laboratories, and the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme (N_HKU 752/08). Y. L., D. Z. and M. S. gratefully acknowledge support from the NIH-NIGMS SC1GM084776 and the NSF CREST program (NSF HRD-0932421).

 
dc.identifier.issn0031-8655
2013 Impact Factor: 2.684
2013 SCImago Journal Rankings: 0.764
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3071644
 
dc.identifier.pmid21155073
 
dc.identifier.scopuseid_2-s2.0-78649684211
 
dc.identifier.spage1414
 
dc.identifier.urihttp://hdl.handle.net/10722/134390
 
dc.identifier.volume86
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/118493575/home
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPhotochemistry and Photobiology
 
dc.relation.projectSelf-assembled metal coordination polymers and supramolecular systems containing π-conjugated organic ligands
 
dc.relation.projectPhosphorescent supramolecular metal-organic receptors for chemical recognition and biomolecular binding applications
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subject.meshCalixarenes - chemistry - pharmacology
 
dc.subject.meshCattle
 
dc.subject.meshOrganoplatinum Compounds - chemistry - pharmacology
 
dc.subject.meshPhotosensitizing Agents - chemistry - pharmacology
 
dc.subject.meshSinglet Oxygen - chemistry
 
dc.titleEfficient singlet oxygen generation by luminescent 2-(2′-thienyl) pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives
 
dc.typeArticle
 
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Author Affiliations
  1. California State University Los Angeles
  2. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong