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Article: Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons

TitleCyclometalated platinum(ii) complexes as topoisomerase IIα poisons
Authors
Liu, JLeung, CHChow, ALFSun, RWYYan, SCChe, CM
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2011, v. 47 n. 2, p. 719-721 How to Cite?
DOI: http://dx.doi.org/10.1039/c0cc03641b
AbstractA platinum(ii)-based major groove binder [PtII(ĈN) (C≡NR)2]+ (HCN = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16. © The Royal Society of Chemistry 2011.
Persistent Identifierhttp://hdl.handle.net/10722/134365
ISSN
1359-7345
2021 Impact Factor: 6.065
2020 SCImago Journal Rankings: 1.837
ISI Accession Number ID
WOS:000285300400028
Funding AgencyGrant Number
Area of Excellence SchemeAoE/P-10/01
Innovation and Technology FundITF-Tier 2
ITS/134/09FP
Funding Information:

We acknowledge support from the Area of Excellence Scheme (AoE/P-10/01) and Innovation and Technology Fund (ITF-Tier 2, ITS/134/09FP).

References
References in Scopus
Grants
Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads
Institute of molecular technology for drug discovery and synthesis

 

DC FieldValueLanguage
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorChow, ALFen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorYan, SCen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2011-06-17T09:18:40Z-
dc.date.available2011-06-17T09:18:40Z-
dc.date.issued2011en_HK
dc.identifier.citationChemical Communications, 2011, v. 47 n. 2, p. 719-721en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134365-
dc.description.abstractA platinum(ii)-based major groove binder [PtII(ĈN) (C≡NR)2]+ (HCN = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16. © The Royal Society of Chemistry 2011.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshCoordination Complexes - chemistry - toxicity-
dc.subject.meshDNA-Binding Proteins - antagonists and inhibitors - metabolism-
dc.subject.meshIntercalating Agents - chemistry - toxicity-
dc.subject.meshPlatinum - chemistry-
dc.subject.meshTopoisomerase II Inhibitors - chemistry - toxicity-
dc.titleCyclometalated platinum(ii) complexes as topoisomerase IIα poisonsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=47&issue=2&spage=719&epage=721&date=2011&atitle=Cyclometalated+platinum(II)+complexes+as+topoisomerase+IIα+poisons-
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c0cc03641ben_HK
dc.identifier.pmid21072335-
dc.identifier.scopuseid_2-s2.0-78651389086en_HK
dc.identifier.hkuros185773en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651389086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue2en_HK
dc.identifier.spage719en_HK
dc.identifier.epage721en_HK
dc.identifier.isiWOS:000285300400028-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectDiscovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads-
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridLiu, J=37122146100en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridChow, ALF=36463401100en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridYan, SC=7401744858en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.issnl1359-7345-

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