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Article: Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons

TitleCyclometalated platinum(ii) complexes as topoisomerase IIα poisons
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2011, v. 47 n. 2, p. 719-721 How to Cite?
AbstractA platinum(ii)-based major groove binder [PtII(ĈN) (C≡NR)2]+ (HCN = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16. © The Royal Society of Chemistry 2011.
Persistent Identifierhttp://hdl.handle.net/10722/134365
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence SchemeAoE/P-10/01
Innovation and Technology FundITF-Tier 2
ITS/134/09FP
Funding Information:

We acknowledge support from the Area of Excellence Scheme (AoE/P-10/01) and Innovation and Technology Fund (ITF-Tier 2, ITS/134/09FP).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorChow, ALFen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorYan, SCen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2011-06-17T09:18:40Z-
dc.date.available2011-06-17T09:18:40Z-
dc.date.issued2011en_HK
dc.identifier.citationChemical Communications, 2011, v. 47 n. 2, p. 719-721en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134365-
dc.description.abstractA platinum(ii)-based major groove binder [PtII(ĈN) (C≡NR)2]+ (HCN = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16. © The Royal Society of Chemistry 2011.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshCoordination Complexes - chemistry - toxicity-
dc.subject.meshDNA-Binding Proteins - antagonists and inhibitors - metabolism-
dc.subject.meshIntercalating Agents - chemistry - toxicity-
dc.subject.meshPlatinum - chemistry-
dc.subject.meshTopoisomerase II Inhibitors - chemistry - toxicity-
dc.titleCyclometalated platinum(ii) complexes as topoisomerase IIα poisonsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=47&issue=2&spage=719&epage=721&date=2011&atitle=Cyclometalated+platinum(II)+complexes+as+topoisomerase+IIα+poisons-
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c0cc03641ben_HK
dc.identifier.pmid21072335-
dc.identifier.scopuseid_2-s2.0-78651389086en_HK
dc.identifier.hkuros185773en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651389086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue2en_HK
dc.identifier.spage719en_HK
dc.identifier.epage721en_HK
dc.identifier.isiWOS:000285300400028-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectDiscovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads-
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridLiu, J=37122146100en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridChow, ALF=36463401100en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridYan, SC=7401744858en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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