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Article: Ruthenium(III) complexes of macrocyclic tertiary amines mediated NO release from S-nitrosothiols under in vitro and in vivo conditions

TitleRuthenium(III) complexes of macrocyclic tertiary amines mediated NO release from S-nitrosothiols under in vitro and in vivo conditions
Authors
KeywordsMacrocyclic ligands
Nitric oxide
Nitrosothiols
Redox chemistry
Ruthenium
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451
Citation
Chemistry - An Asian Journal, 2010, v. 5 n. 9, p. 1965-1969 How to Cite?
AbstractThere's just NO SNAP! RuIII complexes of macrocyclic tertiary amines, especially trans-[Ru(14-TMC)Cl2]Cl (1), could mediate nitric oxide (NO) release from S-nitrosothiols in the presence of biological reductants. Interestingly, complex 1 was found to enhance rat aorta relaxation in the presence of S-nitroso-N-acetylpenicillamine (SNAP) under in vivo conditions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/134354
ISSN
2015 Impact Factor: 4.592
2015 SCImago Journal Rankings: 1.833
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of Hong Kong SARAoE/P 10/01
Funding Information:

The work was supported by the Area of Excellence (AoE/P 10/01) established under the University Grants Committee of Hong Kong SAR. We are grateful to Professor Ricky Y.-K. Man at the Department of Pharmacology and Pharmacy of the University of Hong Kong for access to the organ bath equipment. We thank reviewers for making suggestions on the reaction mechanism.

References

 

DC FieldValueLanguage
dc.contributor.authorHo, CMen_HK
dc.contributor.authorLeung, HCen_HK
dc.contributor.authorLok, CNen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2011-06-17T09:18:31Z-
dc.date.available2011-06-17T09:18:31Z-
dc.date.issued2010en_HK
dc.identifier.citationChemistry - An Asian Journal, 2010, v. 5 n. 9, p. 1965-1969en_HK
dc.identifier.issn1861-4728en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134354-
dc.description.abstractThere's just NO SNAP! RuIII complexes of macrocyclic tertiary amines, especially trans-[Ru(14-TMC)Cl2]Cl (1), could mediate nitric oxide (NO) release from S-nitrosothiols in the presence of biological reductants. Interestingly, complex 1 was found to enhance rat aorta relaxation in the presence of S-nitroso-N-acetylpenicillamine (SNAP) under in vivo conditions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451en_HK
dc.relation.ispartofChemistry - An Asian Journalen_HK
dc.subjectMacrocyclic ligandsen_HK
dc.subjectNitric oxideen_HK
dc.subjectNitrosothiolsen_HK
dc.subjectRedox chemistryen_HK
dc.subjectRutheniumen_HK
dc.titleRuthenium(III) complexes of macrocyclic tertiary amines mediated NO release from S-nitrosothiols under in vitro and in vivo conditionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1861-4728&volume=5&issue=9&spage=1965&epage=1969&date=2010&atitle=Ruthenium(III)+complexes+of+macrocyclic+tertiary+amines+mediated+NO+release+from+s-nitrosothiols+under+in+vitro+and+in+vivo+conditions-
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailLok, CN: cnlok@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityLok, CN=rp00752en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/asia.201000368en_HK
dc.identifier.pmid20669220-
dc.identifier.scopuseid_2-s2.0-77956492744en_HK
dc.identifier.hkuros185605en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956492744&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1965en_HK
dc.identifier.epage1969en_HK
dc.identifier.isiWOS:000281916600003-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridLeung, HC=36504260400en_HK
dc.identifier.scopusauthoridLok, CN=7006410829en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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