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Article: Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

TitleSpecific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes
Authors
Keywordsbioinorganic chemistry
DNA recognition
metallodrugs
platinum
transcription factors
Issue Date2011
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2011, v. 50 n. 11, p. 2554-2558 How to Cite?
AbstractIn the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/134351
ISSN
2015 Impact Factor: 11.709
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of the Hong Kong Special Administrative Region, ChinaAoE/P-10/01
University of Hong Kong
Innovation Technology FundITS/134/09FP
Funding Information:

This work was supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), The University of Hong Kong (University Development Fund), and the Innovation Technology Fund (ITS/134/09FP) administrated by the Innovation Technology Commission of the Hong Kong Special Administrative Region, China. CREB=cAMP response element binding protein.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorWang, Pen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorMa, DLen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorYan, SCen_HK
dc.contributor.authorChen, QSen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2011-06-17T09:18:28Z-
dc.date.available2011-06-17T09:18:28Z-
dc.date.issued2011en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2011, v. 50 n. 11, p. 2554-2558en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134351-
dc.description.abstractIn the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectbioinorganic chemistryen_HK
dc.subjectDNA recognitionen_HK
dc.subjectmetallodrugsen_HK
dc.subjectplatinumen_HK
dc.subjecttranscription factorsen_HK
dc.titleSpecific blocking of CREB/DNA binding by cyclometalated platinum(II) complexesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-7851&volume=50&issue=11&spage=2554&epage=2558&date=2011&atitle=Specific+blocking+of+CREB/DNA+binding+by+cyclometalated+platinum(II)+complexes-
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.emailMa, DL:edmondma@hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.identifier.authorityMa, DL=rp00760en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201006887en_HK
dc.identifier.pmid21370336-
dc.identifier.scopuseid_2-s2.0-79952263626en_HK
dc.identifier.hkuros185600en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952263626&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2554en_HK
dc.identifier.epage2558en_HK
dc.identifier.isiWOS:000288037600019-
dc.publisher.placeGermanyen_HK
dc.relation.projectDiscovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads-
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridWang, P=36515764900en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridMa, DL=7402075538en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridYan, SC=7401744858en_HK
dc.identifier.scopusauthoridChen, QS=37051760800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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