Article: Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface
File Download
(May Require Subscription)
- No File Attached
(May Require Subscription)
- Publisher Website: 10.1111/j.1600-0501.2010.02113.x
- Scopus: eid_2-s2.0-79952506850
- PMID: 21561478
- Find via
Supplementary
-
Citations:
-
Appears in Collections:
| Title | Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface | ||||
|---|---|---|---|---|---|
| Authors | Donos, N1 Hamlet, S3 Lang, NP2 Salvi, GE4 HuynhBa, G4 Bosshardt, DD4 Ivanovski, S3 | ||||
| Keywords | Gene expression Human Hydrophilic surface Oral implants Osseointegration Surface roughness Transcriptome | ||||
| Issue Date | 2011 | ||||
| Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR | ||||
| Citation | Clinical Oral Implants Research, 2011, v. 22 n. 4, p. 365-372 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0501.2010.02113.x | ||||
| Abstract | Objectives: To compare the gene expression profile of osseointegration associated with a moderately rough and a chemically modified hydrophilic moderately rough surface in a human model. Material and methods: Eighteen solid screw-type cylindrical titanium implants, 4mm long and 2.8mm wide, with either a moderately rough (SLA) or a chemically modified moderately rough (SLActive) surface were surgically inserted in the retromolar area of nine human volunteers. The devices were removed using a trephine following 4, 7 and 14 days of healing. The tissue surrounding the implant was harvested, total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between the SLA and SLActive surfaces at days 4, 7 and 14. Results: There were no functionally relevant gene ontology categories that were over-represented in the list of genes that were differentially expressed at day 4. However, by day 7, osteogenesis- and angiogenesis-associated gene expression were up-regulated on the SLActive surface. Osteogenesis and angiogenesis appeared to be regulated by BMP and VEGF signalling, respectively. By day 14, VEGF signalling remains up-regulated on the SLActive surface, while BMP signalling was up-regulated on the SLA surface in what appeared to be a delayed compensatory response. Furthermore, neurogenesis was a prominent biological process within the list of differentially expressed genes, and it was influenced by both surfaces. Conclusions: Compared with SLA, SLActive exerts a pro-osteogenic and pro-angiogenic influence on gene expression at day 7 following implant insertion, which may be responsible for the superior osseointegrative properties of this surface. © 2011 John Wiley & Sons A/S. | ||||
| ISSN | 0905-7161 2011 Impact Factor: 2.514 2011 SCImago Journal Rankings: 0.117 | ||||
| DOI | http://dx.doi.org/10.1111/j.1600-0501.2010.02113.x | ||||
| ISI Accession Number ID | WOS:000288214300003
Funding Information: This study was supported by a grant from the ITI Foundation for the Promotion of Implantology (ITI Basel, Switzerland) Nr. 371/04. | ||||
| References | References in Scopus |
| dc.contributor.author | Donos, N | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Hamlet, S | ||||
| dc.contributor.author | Lang, NP | ||||
| dc.contributor.author | Salvi, GE | ||||
| dc.contributor.author | HuynhBa, G | ||||
| dc.contributor.author | Bosshardt, DD | ||||
| dc.contributor.author | Ivanovski, S | ||||
| dc.date.accessioned | 2011-06-17T09:18:03Z | ||||
| dc.date.available | 2011-06-17T09:18:03Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | Objectives: To compare the gene expression profile of osseointegration associated with a moderately rough and a chemically modified hydrophilic moderately rough surface in a human model. Material and methods: Eighteen solid screw-type cylindrical titanium implants, 4mm long and 2.8mm wide, with either a moderately rough (SLA) or a chemically modified moderately rough (SLActive) surface were surgically inserted in the retromolar area of nine human volunteers. The devices were removed using a trephine following 4, 7 and 14 days of healing. The tissue surrounding the implant was harvested, total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between the SLA and SLActive surfaces at days 4, 7 and 14. Results: There were no functionally relevant gene ontology categories that were over-represented in the list of genes that were differentially expressed at day 4. However, by day 7, osteogenesis- and angiogenesis-associated gene expression were up-regulated on the SLActive surface. Osteogenesis and angiogenesis appeared to be regulated by BMP and VEGF signalling, respectively. By day 14, VEGF signalling remains up-regulated on the SLActive surface, while BMP signalling was up-regulated on the SLA surface in what appeared to be a delayed compensatory response. Furthermore, neurogenesis was a prominent biological process within the list of differentially expressed genes, and it was influenced by both surfaces. Conclusions: Compared with SLA, SLActive exerts a pro-osteogenic and pro-angiogenic influence on gene expression at day 7 following implant insertion, which may be responsible for the superior osseointegrative properties of this surface. © 2011 John Wiley & Sons A/S. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Clinical Oral Implants Research, 2011, v. 22 n. 4, p. 365-372 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0501.2010.02113.x | ||||
| dc.identifier.citeulike | 8993412 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1600-0501.2010.02113.x | ||||
| dc.identifier.epage | 372 | ||||
| dc.identifier.hkuros | 185682 | ||||
| dc.identifier.isi | WOS:000288214300003
Funding Information: This study was supported by a grant from the ITI Foundation for the Promotion of Implantology (ITI Basel, Switzerland) Nr. 371/04. | ||||
| dc.identifier.issn | 0905-7161 2011 Impact Factor: 2.514 2011 SCImago Journal Rankings: 0.117 | ||||
| dc.identifier.issue | 4 | ||||
| dc.identifier.openurl | | ||||
| dc.identifier.pmid | 21561478 | ||||
| dc.identifier.scopus | eid_2-s2.0-79952506850 | ||||
| dc.identifier.spage | 365 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/134338 | ||||
| dc.identifier.volume | 22 | ||||
| dc.language | eng | ||||
| dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Clinical Oral Implants Research | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | The definitive version is available at www3.interscience.wiley.com | ||||
| dc.subject | Gene expression | ||||
| dc.subject | Human | ||||
| dc.subject | Hydrophilic surface | ||||
| dc.subject | Oral implants | ||||
| dc.subject | Osseointegration | ||||
| dc.subject | Surface roughness | ||||
| dc.subject | Transcriptome | ||||
| dc.title | Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface | ||||
| dc.type | Article |
Author Affiliations
- UCL Eastman Dental Institute
- The University of Hong Kong
- Griffith University
- Universität Bern