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Article: The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man
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TitleThe role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man
 
AuthorsBosshardt, DD5
Salvi, GE5
HuynhBa, G5 3
Ivanovski, S4
Donos, N1
Lang, NP5 2
 
KeywordsBone debris
Dental implants
Human
Osseointegration
SLA ®
SLActive ®
Surface characteristics
Wound healing
 
Issue Date2011
 
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
CitationClinical Oral Implants Research, 2011, v. 22 n. 4, p. 357-364 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2010.02107.x
 
AbstractObjective: To evaluate morphologically and morphometrically the sequential healing and osseointegration events at moderately rough implant surfaces with and without chemical modification. Particularly the role of bone debris in initiating bone formation was emphasized. Material and methods: Solid, screw-type cylindrical titanium implants (SSI) (n=49), 4mm long and 2.8mm wide, with either chemically modified (SLActive ®) or sandblasted and acid-etched (SLA ®) surface configurations were surgically installed in the retromolar region of 28 human volunteers. After 7, 14, 28 and 42 days of submerged healing, the devices were retrieved with a trephine. Histologic ground sections were prepared and histomorphometrically analyzed. Linear measurements determined fractions of old bone (OBIC), new bone (NBIC), soft tissue (ST) and bone debris (BD) in contact with the SSI surfaces. Results: Healing was uneventful at all installation sites. Sixty-one percent of all devices were suitable for morphometric analyses. All implant surfaces were partially coated with bone debris and new bone formation was observed as early as 7 days after installation. There was a gradual increase in NBIC, whereas OBIC, ST and BD progressively decreased over time. NBIC after 2 and 4 weeks was higher on SLActive ® than on SLA ® surfaces, albeit statistically not significant. The BD:ST ratio changed significantly from 7 to 42 days (from 50:50 to 10:90 for SLActive ®; from 38:62 to 10:90 for SLA ®) (Fisher's exact test, P<0.01). Conclusion: Both SLActive ® and SLA ® devices became progressively osseointegrated, while old bone on the device surface was gradually resorbed. The decrease in BD:ST ratio suggests that bone debris, created during implant installation and adhering to moderately rough surfaces, significantly contributed to the initiation of bone deposition and mediated the connection between the old bone and the new bone on the implant surface. © 2011 John Wiley & Sons A/S.
 
ISSN0905-7161
2013 Impact Factor: 3.123
 
DOIhttp://dx.doi.org/10.1111/j.1600-0501.2010.02107.x
 
ISI Accession Number IDWOS:000288214300002
Funding AgencyGrant Number
ITI Foundation (ITI, Basel Switzerland)371/04
Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, SwitzerlandCRF 022/07
Funding Information:

The authors are indebted to Mr D. Reist, Mrs M. Aeberhard and Mrs S. Owusu for excellent technical assistance in the laboratory, to Mr W. Burgin for performing the statistical analysis. The organizational help of the clinical team of the former Department of Periodontology and Fixed Prosthodontics of the University of Berne is duely acknowledged. Last, but not least, a great acknowledgement belongs to the volunteer students and employees of the University of Berne School of Dental Medicine for having participated in the study. This study was supported by a grant (371/04) from the ITI Foundation (ITI, Basel Switzerland) and by the Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland (CRF 022/07).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBosshardt, DD
 
dc.contributor.authorSalvi, GE
 
dc.contributor.authorHuynhBa, G
 
dc.contributor.authorIvanovski, S
 
dc.contributor.authorDonos, N
 
dc.contributor.authorLang, NP
 
dc.date.accessioned2011-06-17T09:18:02Z
 
dc.date.available2011-06-17T09:18:02Z
 
dc.date.issued2011
 
dc.description.abstractObjective: To evaluate morphologically and morphometrically the sequential healing and osseointegration events at moderately rough implant surfaces with and without chemical modification. Particularly the role of bone debris in initiating bone formation was emphasized. Material and methods: Solid, screw-type cylindrical titanium implants (SSI) (n=49), 4mm long and 2.8mm wide, with either chemically modified (SLActive ®) or sandblasted and acid-etched (SLA ®) surface configurations were surgically installed in the retromolar region of 28 human volunteers. After 7, 14, 28 and 42 days of submerged healing, the devices were retrieved with a trephine. Histologic ground sections were prepared and histomorphometrically analyzed. Linear measurements determined fractions of old bone (OBIC), new bone (NBIC), soft tissue (ST) and bone debris (BD) in contact with the SSI surfaces. Results: Healing was uneventful at all installation sites. Sixty-one percent of all devices were suitable for morphometric analyses. All implant surfaces were partially coated with bone debris and new bone formation was observed as early as 7 days after installation. There was a gradual increase in NBIC, whereas OBIC, ST and BD progressively decreased over time. NBIC after 2 and 4 weeks was higher on SLActive ® than on SLA ® surfaces, albeit statistically not significant. The BD:ST ratio changed significantly from 7 to 42 days (from 50:50 to 10:90 for SLActive ®; from 38:62 to 10:90 for SLA ®) (Fisher's exact test, P<0.01). Conclusion: Both SLActive ® and SLA ® devices became progressively osseointegrated, while old bone on the device surface was gradually resorbed. The decrease in BD:ST ratio suggests that bone debris, created during implant installation and adhering to moderately rough surfaces, significantly contributed to the initiation of bone deposition and mediated the connection between the old bone and the new bone on the implant surface. © 2011 John Wiley & Sons A/S.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationClinical Oral Implants Research, 2011, v. 22 n. 4, p. 357-364 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2010.02107.x
 
dc.identifier.citeulike8993413
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0501.2010.02107.x
 
dc.identifier.epage364
 
dc.identifier.hkuros185681
 
dc.identifier.isiWOS:000288214300002
Funding AgencyGrant Number
ITI Foundation (ITI, Basel Switzerland)371/04
Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, SwitzerlandCRF 022/07
Funding Information:

The authors are indebted to Mr D. Reist, Mrs M. Aeberhard and Mrs S. Owusu for excellent technical assistance in the laboratory, to Mr W. Burgin for performing the statistical analysis. The organizational help of the clinical team of the former Department of Periodontology and Fixed Prosthodontics of the University of Berne is duely acknowledged. Last, but not least, a great acknowledgement belongs to the volunteer students and employees of the University of Berne School of Dental Medicine for having participated in the study. This study was supported by a grant (371/04) from the ITI Foundation (ITI, Basel Switzerland) and by the Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland (CRF 022/07).

 
dc.identifier.issn0905-7161
2013 Impact Factor: 3.123
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid21561477
 
dc.identifier.scopuseid_2-s2.0-79952495179
 
dc.identifier.spage357
 
dc.identifier.urihttp://hdl.handle.net/10722/134337
 
dc.identifier.volume22
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Oral Implants Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subjectBone debris
 
dc.subjectDental implants
 
dc.subjectHuman
 
dc.subjectOsseointegration
 
dc.subjectSLA ®
 
dc.subjectSLActive ®
 
dc.subjectSurface characteristics
 
dc.subjectWound healing
 
dc.titleThe role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man
 
dc.typeArticle
 
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Author Affiliations
  1. UCL Eastman Dental Institute
  2. The University of Hong Kong
  3. University of Texas Health Science Center at San Antonio
  4. Griffith University
  5. Universität Bern