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Article: Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans

TitleEarly osseointegration to hydrophilic and hydrophobic implant surfaces in humans
Authors
KeywordsBone-to-implant contact
Human
Hydrophilic
Hydrophobic
Implant surfaces
Oral implants
Osseointegration
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2011, v. 22 n. 4, p. 349-356 How to Cite?
AbstractObjective: To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model. Material and methods: The devices used for this study of early healing were 4mm long and 2.8mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9mm inside diameter, allowing the circumferential sampling of 1mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed. Results: All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8% vs. 12.2% and 48.3% vs. 32.4%, respectively), but after 42 days, these differences were no longer evident (61.6% vs. 61.5%). Conclusion: While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface. © 2011 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/134336
ISSN
2014 Impact Factor: 3.889
ISI Accession Number ID
Funding AgencyGrant Number
ITI Foundation for the Promotion of Implantology (ITI Basel, Switzerland)371/04
Clinical Research Foundation (CRF) for the Promotion of Oral Health122/07
Funding Information:

This study has been supported by a grant from the ITI Foundation for the Promotion of Implantology (ITI Basel, Switzerland) (No. 371/04). Further support came from the Clinical Research Foundation (CRF) for the Promotion of Oral Health (No. 122/07). The excellent and competent laboratory work of Mrs. Monika Aeberhard, Ms. Silvia Owusu and Mr. David Reist as well as Mr. Walter Burgin for performing the statistical analysis is highly appreciated. The organizational help of the clinical team of the former Department of Periodontology and Fixed Prosthodontics of the University of Berne is duly acknowledged. Last, but not least, a great acknowledgement belongs to the volunteer students and employees of the University of Berne School of Dental Medicine for having participated in the study.

References

 

DC FieldValueLanguage
dc.contributor.authorLang, NPen_HK
dc.contributor.authorSalvi, GEen_HK
dc.contributor.authorHuynhBa, Gen_HK
dc.contributor.authorIvanovski, Sen_HK
dc.contributor.authorDonos, Nen_HK
dc.contributor.authorBosshardt, DDen_HK
dc.date.accessioned2011-06-17T09:18:02Z-
dc.date.available2011-06-17T09:18:02Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical Oral Implants Research, 2011, v. 22 n. 4, p. 349-356en_HK
dc.identifier.issn0905-7161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134336-
dc.description.abstractObjective: To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model. Material and methods: The devices used for this study of early healing were 4mm long and 2.8mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9mm inside diameter, allowing the circumferential sampling of 1mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed. Results: All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8% vs. 12.2% and 48.3% vs. 32.4%, respectively), but after 42 days, these differences were no longer evident (61.6% vs. 61.5%). Conclusion: While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface. © 2011 John Wiley & Sons A/S.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_HK
dc.relation.ispartofClinical Oral Implants Researchen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectBone-to-implant contacten_HK
dc.subjectHumanen_HK
dc.subjectHydrophilicen_HK
dc.subjectHydrophobicen_HK
dc.subjectImplant surfacesen_HK
dc.subjectOral implantsen_HK
dc.subjectOsseointegrationen_HK
dc.titleEarly osseointegration to hydrophilic and hydrophobic implant surfaces in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0905-7161&volume=22&issue=4&spage=349&epage=356&date=2011&atitle=Early+osseointegration+to+hydrophilic+and+hydrophobic+implant+surfaces+in+humans-
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_HK
dc.identifier.authorityLang, NP=rp00031en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0501.2011.02172.xen_HK
dc.identifier.pmid21561476en_HK
dc.identifier.scopuseid_2-s2.0-79952522844en_HK
dc.identifier.hkuros185680en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952522844&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage349en_HK
dc.identifier.epage356en_HK
dc.identifier.isiWOS:000288214300001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLang, NP=7201577367en_HK
dc.identifier.scopusauthoridSalvi, GE=35600695300en_HK
dc.identifier.scopusauthoridHuynhBa, G=25825004200en_HK
dc.identifier.scopusauthoridIvanovski, S=6601979085en_HK
dc.identifier.scopusauthoridDonos, N=7004314492en_HK
dc.identifier.scopusauthoridBosshardt, DD=6603806230en_HK
dc.identifier.citeulike8993414-

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