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Article: HPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditions

TitleHPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditions
Authors
Keywords3, 4-Diaminopyridine
Column liquid chromatography
Stability-indicating assay method
Validation method
Issue Date2006
PublisherFriedr Vieweg und Sohn Verlagsgesellschaft mbH. The Journal's web site is located at http://www.elsevier.com/locate/chromatographia
Citation
Chromatographia, 2006, v. 63 n. 11-12, p. 599-603 How to Cite?
Abstract3,4-Diaminopyridine is used to treat some symptoms met in Lambert Eaton myasthenia syndrome. It was shown efficient to reduce a form of variable muscle weakness and fatigability typical of the disease and correlated to a block of acetylcholine release. A high performance liquid chromatographic method for the determination of 3,4-diaminopyridine in the presence of related substances and its degradation products is described. The method is based on the use of a C18 bonded phase column and a mobile phase composed of 10 volumes of acetonitrile and 90 volumes of an aqueous solution containing 1 g L-1 sodium octanesulfonate and 0.77 g L-1 ammonium acetate. The pH of the aqueous solution was adjusted to 1.9 with trifluoracetic acid. All peaks are eluted in <40 min. The method was demonstrated to be precise, accurate and specific even though a major part of the drug is decomposed. The results indicate that the proposed method could be used in stability assays. © 2006 Friedr. Vieweg & Sohn/GWV Fachverlage GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/134253
ISSN
2015 Impact Factor: 1.332
2015 SCImago Journal Rankings: 0.480
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDo, Ben_HK
dc.contributor.authorGoulayDufaÿ, Sen_HK
dc.contributor.authorLe Hoang, MDen_HK
dc.contributor.authorRaust, JAen_HK
dc.contributor.authorGuyon, Fen_HK
dc.contributor.authorGraffard, Hen_HK
dc.contributor.authorPradeau, Den_HK
dc.date.accessioned2011-06-14T09:09:26Z-
dc.date.available2011-06-14T09:09:26Z-
dc.date.issued2006en_HK
dc.identifier.citationChromatographia, 2006, v. 63 n. 11-12, p. 599-603en_HK
dc.identifier.issn0009-5893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134253-
dc.description.abstract3,4-Diaminopyridine is used to treat some symptoms met in Lambert Eaton myasthenia syndrome. It was shown efficient to reduce a form of variable muscle weakness and fatigability typical of the disease and correlated to a block of acetylcholine release. A high performance liquid chromatographic method for the determination of 3,4-diaminopyridine in the presence of related substances and its degradation products is described. The method is based on the use of a C18 bonded phase column and a mobile phase composed of 10 volumes of acetonitrile and 90 volumes of an aqueous solution containing 1 g L-1 sodium octanesulfonate and 0.77 g L-1 ammonium acetate. The pH of the aqueous solution was adjusted to 1.9 with trifluoracetic acid. All peaks are eluted in <40 min. The method was demonstrated to be precise, accurate and specific even though a major part of the drug is decomposed. The results indicate that the proposed method could be used in stability assays. © 2006 Friedr. Vieweg & Sohn/GWV Fachverlage GmbH.en_HK
dc.languageeng-
dc.publisherFriedr Vieweg und Sohn Verlagsgesellschaft mbH. The Journal's web site is located at http://www.elsevier.com/locate/chromatographiaen_HK
dc.relation.ispartofChromatographiaen_HK
dc.subject3, 4-Diaminopyridineen_HK
dc.subjectColumn liquid chromatographyen_HK
dc.subjectStability-indicating assay methoden_HK
dc.subjectValidation methoden_HK
dc.titleHPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-5893&volume=63&issue=11-12&spage=599&epage=603&date=2006&atitle=HPLC+method+for+determination+of+3,4-diaminopyridine+in+the+presence+of+related+substances+and+degradation+products+formed+under+stress+conditions-
dc.identifier.emailGoulayDufaÿ, S: sdufay@hku.hken_HK
dc.identifier.authorityGoulayDufaÿ, S=rp01491en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1365/s10337-006-0821-yen_HK
dc.identifier.scopuseid_2-s2.0-33745157868en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745157868&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue11-12en_HK
dc.identifier.spage599en_HK
dc.identifier.epage603en_HK
dc.identifier.isiWOS:000238905200012-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridDo, B=7003399176en_HK
dc.identifier.scopusauthoridGoulayDufaÿ, S=6507768346en_HK
dc.identifier.scopusauthoridLe Hoang, MD=6603079461en_HK
dc.identifier.scopusauthoridRaust, JA=6603461316en_HK
dc.identifier.scopusauthoridGuyon, F=7006952930en_HK
dc.identifier.scopusauthoridGraffard, H=6507325901en_HK
dc.identifier.scopusauthoridPradeau, D=7003279930en_HK

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