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Article: HPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditions
Title | HPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditions |
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Authors | |
Keywords | 3, 4-Diaminopyridine Column liquid chromatography Stability-indicating assay method Validation method |
Issue Date | 2006 |
Publisher | Friedr Vieweg und Sohn Verlagsgesellschaft mbH. The Journal's web site is located at http://www.elsevier.com/locate/chromatographia |
Citation | Chromatographia, 2006, v. 63 n. 11-12, p. 599-603 How to Cite? |
Abstract | 3,4-Diaminopyridine is used to treat some symptoms met in Lambert Eaton myasthenia syndrome. It was shown efficient to reduce a form of variable muscle weakness and fatigability typical of the disease and correlated to a block of acetylcholine release. A high performance liquid chromatographic method for the determination of 3,4-diaminopyridine in the presence of related substances and its degradation products is described. The method is based on the use of a C18 bonded phase column and a mobile phase composed of 10 volumes of acetonitrile and 90 volumes of an aqueous solution containing 1 g L-1 sodium octanesulfonate and 0.77 g L-1 ammonium acetate. The pH of the aqueous solution was adjusted to 1.9 with trifluoracetic acid. All peaks are eluted in <40 min. The method was demonstrated to be precise, accurate and specific even though a major part of the drug is decomposed. The results indicate that the proposed method could be used in stability assays. © 2006 Friedr. Vieweg & Sohn/GWV Fachverlage GmbH. |
Persistent Identifier | http://hdl.handle.net/10722/134253 |
ISSN | 2023 Impact Factor: 1.2 2023 SCImago Journal Rankings: 0.301 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Do, B | en_HK |
dc.contributor.author | GoulayDufaÿ, S | en_HK |
dc.contributor.author | Le Hoang, MD | en_HK |
dc.contributor.author | Raust, JA | en_HK |
dc.contributor.author | Guyon, F | en_HK |
dc.contributor.author | Graffard, H | en_HK |
dc.contributor.author | Pradeau, D | en_HK |
dc.date.accessioned | 2011-06-14T09:09:26Z | - |
dc.date.available | 2011-06-14T09:09:26Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Chromatographia, 2006, v. 63 n. 11-12, p. 599-603 | en_HK |
dc.identifier.issn | 0009-5893 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/134253 | - |
dc.description.abstract | 3,4-Diaminopyridine is used to treat some symptoms met in Lambert Eaton myasthenia syndrome. It was shown efficient to reduce a form of variable muscle weakness and fatigability typical of the disease and correlated to a block of acetylcholine release. A high performance liquid chromatographic method for the determination of 3,4-diaminopyridine in the presence of related substances and its degradation products is described. The method is based on the use of a C18 bonded phase column and a mobile phase composed of 10 volumes of acetonitrile and 90 volumes of an aqueous solution containing 1 g L-1 sodium octanesulfonate and 0.77 g L-1 ammonium acetate. The pH of the aqueous solution was adjusted to 1.9 with trifluoracetic acid. All peaks are eluted in <40 min. The method was demonstrated to be precise, accurate and specific even though a major part of the drug is decomposed. The results indicate that the proposed method could be used in stability assays. © 2006 Friedr. Vieweg & Sohn/GWV Fachverlage GmbH. | en_HK |
dc.language | eng | - |
dc.publisher | Friedr Vieweg und Sohn Verlagsgesellschaft mbH. The Journal's web site is located at http://www.elsevier.com/locate/chromatographia | en_HK |
dc.relation.ispartof | Chromatographia | en_HK |
dc.subject | 3, 4-Diaminopyridine | en_HK |
dc.subject | Column liquid chromatography | en_HK |
dc.subject | Stability-indicating assay method | en_HK |
dc.subject | Validation method | en_HK |
dc.title | HPLC method for determination of 3,4-diaminopyridine in the presence of related substances and degradation products formed under stress conditions | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-5893&volume=63&issue=11-12&spage=599&epage=603&date=2006&atitle=HPLC+method+for+determination+of+3,4-diaminopyridine+in+the+presence+of+related+substances+and+degradation+products+formed+under+stress+conditions | - |
dc.identifier.email | GoulayDufaÿ, S: sdufay@hku.hk | en_HK |
dc.identifier.authority | GoulayDufaÿ, S=rp01491 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1365/s10337-006-0821-y | en_HK |
dc.identifier.scopus | eid_2-s2.0-33745157868 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33745157868&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 63 | en_HK |
dc.identifier.issue | 11-12 | en_HK |
dc.identifier.spage | 599 | en_HK |
dc.identifier.epage | 603 | en_HK |
dc.identifier.isi | WOS:000238905200012 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Do, B=7003399176 | en_HK |
dc.identifier.scopusauthorid | GoulayDufaÿ, S=6507768346 | en_HK |
dc.identifier.scopusauthorid | Le Hoang, MD=6603079461 | en_HK |
dc.identifier.scopusauthorid | Raust, JA=6603461316 | en_HK |
dc.identifier.scopusauthorid | Guyon, F=7006952930 | en_HK |
dc.identifier.scopusauthorid | Graffard, H=6507325901 | en_HK |
dc.identifier.scopusauthorid | Pradeau, D=7003279930 | en_HK |
dc.identifier.issnl | 0009-5893 | - |