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Article: Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox

TitleStill protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.com
Citation
Epidemiology, 2006, v. 17 n. 5, p. 576-581 How to Cite?
AbstractBACKGROUND: Although the potential for bioterrorism has led to discussions on the durability of vaccine-induced immunity, the actual duration of protection against smallpox is still unknown. It has previously been suggested that at least partial protection against severe and fatal smallpox may persist throughout life. METHODS: In this article, we analyzed 6 major smallpox outbreaks that occurred before and after 1900 in the United Kingdom. These analyses are based on the age-dependent incidence of smallpox and the fraction of severe manifestations among individuals with or without prior vaccination. We used a likelihood-based approach to estimate the duration of immunity from the age-specific frequencies. RESULTS: The expected median duration of protection from disease ranged from 11.7 to 28.4 years after primary vaccination, and the qualitative pattern of duration could be described using Gompertz's Law. Vaccinated individuals appear to have been protected from severe disease with more than 50% probability even 50 years after successful primary vaccination. CONCLUSIONS: These findings suggest that successful primary vaccination offered full protection for a few decades, with partial protection from severe smallpox possibly lasting a lifetime, for a substantial fraction of the population. Copyright © 2006 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/134235
ISSN
2015 Impact Factor: 6.075
2015 SCImago Journal Rankings: 2.981
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorSchwehm, Men_HK
dc.contributor.authorEichner, Men_HK
dc.date.accessioned2011-06-13T07:20:58Z-
dc.date.available2011-06-13T07:20:58Z-
dc.date.issued2006en_HK
dc.identifier.citationEpidemiology, 2006, v. 17 n. 5, p. 576-581en_HK
dc.identifier.issn1044-3983en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134235-
dc.description.abstractBACKGROUND: Although the potential for bioterrorism has led to discussions on the durability of vaccine-induced immunity, the actual duration of protection against smallpox is still unknown. It has previously been suggested that at least partial protection against severe and fatal smallpox may persist throughout life. METHODS: In this article, we analyzed 6 major smallpox outbreaks that occurred before and after 1900 in the United Kingdom. These analyses are based on the age-dependent incidence of smallpox and the fraction of severe manifestations among individuals with or without prior vaccination. We used a likelihood-based approach to estimate the duration of immunity from the age-specific frequencies. RESULTS: The expected median duration of protection from disease ranged from 11.7 to 28.4 years after primary vaccination, and the qualitative pattern of duration could be described using Gompertz's Law. Vaccinated individuals appear to have been protected from severe disease with more than 50% probability even 50 years after successful primary vaccination. CONCLUSIONS: These findings suggest that successful primary vaccination offered full protection for a few decades, with partial protection from severe smallpox possibly lasting a lifetime, for a substantial fraction of the population. Copyright © 2006 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.comen_HK
dc.relation.ispartofEpidemiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAge Factorsen_HK
dc.subject.meshDemographyen_HK
dc.subject.meshDisease Outbreaksen_HK
dc.subject.meshEpidemiologic Factorsen_HK
dc.subject.meshGreat Britain - epidemiologyen_HK
dc.subject.meshHistory, 19th Centuryen_HK
dc.subject.meshHistory, 20th Centuryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunity - immunologyen_HK
dc.subject.meshImmunization Programsen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshPoisson Distributionen_HK
dc.subject.meshSmallpox - epidemiology - immunology - prevention & controlen_HK
dc.subject.meshSmallpox Vaccine - immunologyen_HK
dc.subject.meshTime Factorsen_HK
dc.titleStill protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpoxen_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/01.ede.0000229196.41862.c2en_HK
dc.identifier.pmid16804475-
dc.identifier.scopuseid_2-s2.0-33747137970en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747137970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue5en_HK
dc.identifier.spage576en_HK
dc.identifier.epage581en_HK
dc.identifier.isiWOS:000240028900017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridSchwehm, M=36980817300en_HK
dc.identifier.scopusauthoridEichner, M=26643365500en_HK

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