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Article: Incubation period as a clinical predictor of botulism: Analysis of previous izushi-borne outbreaks in Hokkaido, Japan, from 1951 to 1965

TitleIncubation period as a clinical predictor of botulism: Analysis of previous izushi-borne outbreaks in Hokkaido, Japan, from 1951 to 1965
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology And Infection, 2007, v. 135 n. 1, p. 126-130 How to Cite?
AbstractThis study investigated 21 foodborne type-E botulism outbreaks, without antitoxin administration, from 1951 to 1965 in Hokkaido, Japan, to characterize the descriptive epidemiology and evaluate the relationship between case fatality and incubation period. The median (25-75% quartile) attack rate and case fatality, which were evaluated by outbreak, were 58.3% (38.0-73.l2) and 25.7% (0.1-50.0) respectively. Individual records of 64 diagnoses, including 31 deaths, were also examined using logistic regression analysis, revealing that a shorter incubation period is likely to result in a significantly higher risk of death (P = 0.01). The observed case fatality was more than 50% for those who developed symptoms within the first 18 h after exposure, possibly reflecting underlying dose-dependent mechanisms. In the event of intentional contamination of food with botulinum toxin, rapidly determining the incubation periods may be critical for guiding public health response efforts. © 2006 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/134230
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 1.320
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.date.accessioned2011-06-13T07:20:57Z-
dc.date.available2011-06-13T07:20:57Z-
dc.date.issued2007en_HK
dc.identifier.citationEpidemiology And Infection, 2007, v. 135 n. 1, p. 126-130en_HK
dc.identifier.issn0950-2688en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134230-
dc.description.abstractThis study investigated 21 foodborne type-E botulism outbreaks, without antitoxin administration, from 1951 to 1965 in Hokkaido, Japan, to characterize the descriptive epidemiology and evaluate the relationship between case fatality and incubation period. The median (25-75% quartile) attack rate and case fatality, which were evaluated by outbreak, were 58.3% (38.0-73.l2) and 25.7% (0.1-50.0) respectively. Individual records of 64 diagnoses, including 31 deaths, were also examined using logistic regression analysis, revealing that a shorter incubation period is likely to result in a significantly higher risk of death (P = 0.01). The observed case fatality was more than 50% for those who developed symptoms within the first 18 h after exposure, possibly reflecting underlying dose-dependent mechanisms. In the event of intentional contamination of food with botulinum toxin, rapidly determining the incubation periods may be critical for guiding public health response efforts. © 2006 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYGen_HK
dc.relation.ispartofEpidemiology and Infectionen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleIncubation period as a clinical predictor of botulism: Analysis of previous izushi-borne outbreaks in Hokkaido, Japan, from 1951 to 1965en_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0950268806006169en_HK
dc.identifier.pmid16684403-
dc.identifier.pmcidPMC2870535-
dc.identifier.scopuseid_2-s2.0-33751373935en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33751373935&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue1en_HK
dc.identifier.spage126en_HK
dc.identifier.epage130en_HK
dc.identifier.eissn1469-4409-
dc.identifier.isiWOS:000243469700017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK

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